Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"In silico modelling"”.
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In silico modelling to advance arterial spin labelling magnetic resonance imaging
Rationale Arterial spin labelling (ASL) magnetic resonance imaging (MRI) of the lungs is an imaging methodology used for the measurement of pulmonary perfusion. Unlike other pulmonary perfusion imaging techniques such as Positron emission tomography (PET), Single-photon emission computed tomography …
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Expression, inhibition and in silico modelling of human neuronal nitric oxide synthase
… (NO) is a free radical, gaseous molecule that is involved in a vast range of biological signalling processes including long term memory formation, neurogenesis, vasodilation and inflammation. The molecule is produced by a family of enzymes called nitric oxide synthases (NOS). There are three major …
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Investigation of in Silico Modelling to Predict the Human Health Effects of Cosmetics Ingredients
… method to assess the safety of chemicals used in cosmetic products for decades. However, public opinion has continued to demand that in vivo hazard identification methods conducted on animals are replaced with alternative methods. Research on alternative methods to replace in vivo toxicity …
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Identification of Novel Acid-Sensing Ion Channel 3 Modulators using in silico Modelling and Screening
Nociception is a protective mechanism alerting an organism to noxious stimuli and potential harm. However, dysregulation of the nociceptive system can result in chronic pain, which has a prevalence of approximately 40 % in the adult population. Current therapeutics are often inefficacious, and the …
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Insights Into the Molecular Mechanisms Driving Rare Neurodegenerative Diseases and Therapeutic Strategies Aided By In Silico Modelling
… è presente nell'allegato / the abstract is in the attachment
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Genetic and functional investigation of sequence variation associated with the related phenotypes: birth weight, obesity, and type 2 diabetes (T2D)
Background: Global incidence of obesity and Type 2 diabetes (T2D) has increased rapidly in the last fifty years and even more rapidly in immigrant ethnic minority communities in Western countries. There is evidence of a connection between birth weight and the subsequent risk of obesity and T2D in …
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Integrating In-Silico Models with In-Vitro Data to Generate Novel Insights into Biological Systems
Models and computational predictions are useful in identifying certain key parameters that play a central role in defining the overall behavior of the system, and thus lead to new and more informative experiments. In this thesis, in-silico models are developed over a range of individual biological …
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In-Silico design and verification of an extracorporeal normothermic cardiac perfusion system for use during heart transplantation procedures
… to ensure successful graft viability. Since the first human heart transplant in 1967 by Christiaan Barnard, organ preservation techniques have evolved from static cold storage with cardioplegic arrest to continuous blood perfusion, which enhances metabolic support and extends viable …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
The increasing use of electronic cigarettes (ECs), particularly among youth, has raised concerns about their impact on respiratory health. This thesis investigates the effects of EC aerosol exposure on the alveolar epithelium using a combination of in silico modelling and in vitro experimentation. …
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In-Silico design and verification of an extracorporeal normothermic cardiac perfusion system for use during heart transplantation procedures
… to ensure successful graft viability. Since the first human heart transplant in 1967 by Christiaan Barnard, organ preservation techniques have evolved from static cold storage with cardioplegic arrest to continuous blood perfusion, which enhances metabolic support and extends viable …
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Mathematical modelling of drug metabolism : using <em>in silico</em> techniques to investigate the cytochrome P450 enzyme system in hepatic reductase null mice
In silico modelling approaches are useful since they can minimise experimental costs and once set up can be used to replace animal testing for drugs. As such modelling techniques need to be developed to reduce dependence on animals for validation of pharmacological efficacy. The work within this …
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Development of Artificial Intelligence-based In-Silico Toxicity Models. Data Quality Analysis and Model Performance Enhancement through Data Generation
Toxic compounds, such as pesticides, are routinely tested against a range of aquatic, avian and mammalian species as part of the registration process. The need for reducing dependence on animal testing has led to an increasing interest in alternative methods such as in silico modelling. The QSAR …
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Development of Artificial Intelligence-based In-Silico Toxicity Models. Data Quality Analysis and Model Performance Enhancement through Data Generation.
Toxic compounds, such as pesticides, are routinely tested against a range of aquatic, avian and mammalian species as part of the registration process. The need for reducing dependence on animal testing has led to an increasing interest in alternative methods such as in silico modelling. The QSAR …
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Development of Artificial Intelligence-based In-Silico Toxicity Models. Data Quality Analysis and Model Performance Enhancement through Data Generation
Toxic compounds, such as pesticides, are routinely tested against a range of aquatic, avian and mammalian species as part of the registration process. The need for reducing dependence on animal testing has led to an increasing interest in alternative methods such as in silico modelling. The QSAR …
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A genomics-led approach to deciphering heterocyclic natural product biosynthesis
Heterocycles play an important role in many biological processes and are widespread among natural products. Oxazole-containing natural products possess a broad range of bioactivities and are of great interest in the pharmaceutical and agrochemical industries. Herein, the biosynthetic routes to the …
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Breast Cancer Progression and Phytoestrogen Interactions with Estrogen Receptors
… cancer is one of the most common diseases affecting women and approximately 1.3 million females are diagnosed each year with this disease worldwide. Breast cancer is a multi-factorial disease and it is difficult to predict or control the physiopathology, to date one of the major risk factors …
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Structural and functional role of the extracellular loops and C-terminal domain of the voltage-gated sodium ion channel
… channels (Nav) are central to action potential initiation through regulating the entry of sodium ions (Na+) into excitable cells including cardiomyocytes and neurones. The α-subunit of Nav consists of four homologous domains (DI-DIV), each consisting of six transmembrane helices (S1-S6). Helices …
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
SUMMARY Title: Age-associated Changes in the Germinal Centre Response upon Vaccination Name: Alyssa Silva Cayetano Vaccination efficacy is reduced in older individuals due to diminished immune system function with advancing age. The germinal centre (GC) response plays a crucial role in generating …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
Allergic diseases continue to pose a significant global health challenge, highlighting the need for more effective, patient-friendly therapeutic approaches. Although antihistamines remain the cornerstone of allergy treatment, their conventional oral administration is limited by extensive first-pass …
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Endoplasmic Reticulum Morphoregulation Modulates Ca2+- Driven Brain Cell Functions
Disruptions in the structural integrity of the Endoplasmic Reticulum (ER) have been associated with various neuronal pathologies, with mutations in some ER morphogens causing motor neurone diseases. The selective vulnerability of long axons highlights the significance of their extensive ER …
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