Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"In Vivo Microdialysis"”.
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Investigation of Carbamathione Pharmacokinetics and Pharmacodynamics by In Vivo Microdialysis and Capillary Electrophoresis
… use of the drug disulfiram for alcoholism is its inhibition of liver aldehyde dehydrogenase (ALDH2). Recent studies have reported that disulfiram exhibited an anti-craving effect with both alcohol addiction and cocaine dependence. Inhibition of ALDH2 cannot explain disulfiram's efficacy in cocaine …
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Investigation Of Dopamine Dynamics In Bdnf+/- Mice Using In Vivo Microdialysis And Electrochemical Analysis Of Purine And Monoamine Molecules Using A Boron-Doped Diamond Electrode
<p>The goal of the first study was to determine if a reduction in brain-derived neurotrophic factor (BDNF) levels in female mice lead to a dysregulation in their dopaminergic system. Through a series of <i>in vivo</i> microdialysis and slice voltammetry experiments, we have discerned that female …
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Electrical stimulation of reward sites in the ventral tegmental area of the rat increases dopamine transmission in the nucleus accumbens as measured by in vivo microdialysis
In vivo microdialysis with HPLC-ED was used to measure dopamine (DA),3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the nucleus accumbens of the rat, prior to, during, and after 15-min periods of electrical brain-stimulation at sites in …
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
… of the amyloid-β: Aβ) peptide into extracellular amyloid plaques. Several autosomal dominant mutations have been shown to cause familial forms of early-onset Alzheimer's disease, but factors that modulate the risk and onset for the more common sporadic, late-onset Alzheimer's …
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The Effect Of An Intermittent Manganese (ii) Exposure On The Striatal Dopamine System
<p>Manganese (Mn), an abundant metal found in soil, air, and many foods is essential for normal body development and functioning. However, excess exposure to Mn results in a neurological disorder known as manganism, which is associated with marked motor impairments that are similar to Parkinson's …
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
… is one of the most commonly prescribed drugs in the United States. MPH is a psychostimulant that inhibits the dopamine (DA) and norepinephrine (NE) transporters to increase extracellular monoamines. Abuse rates of MPH are increasing as prescription rates increase, but the effects of high-dose, …
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Investigations of the neurobiological and behavioural actions of cocaine
… considered a benign recreational stimulant, cocaine is now recognized to possess substantial abuse potential with considerable medical and social consequences. Accordingly, these experiments examined the behavioural and neurobiological effects of cocaine in the rat. The behavioural and …
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Neurochemical Mechanisms in the Hypothalamus and Attenuation of Compensatory Hormone Responses to Recurrent Hypoglycemia
For the purpose of testing this hypothesis a new rat model of recurrent hypoglycemia was used in combination with in vivo microdialysis. This enabled the simultaneous evaluation of circulating glucose and hormones, as well as extracellular concentrations of glucose and norepinephrine (NE) in …
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Mechanisms of Brain Region-Specific Amyloid-beta Deposition
… of dementia. A fundamental feature of AD is brain region-specific deposition of extracellular amyloid plaques principally comprised of the amyloid-β: Aβ) peptide. Using mouse models of cerebral Aβ deposition, we examined molecular, cellular and systems-level mechanisms that …
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Effect of low endogenous brain-derived neurotrophic factor levels on striatal dopamine dynamics
… neurotransmitters, neuromodulators, and/or proteins. Specifically, one protein that has been linked to numerous neurological diseases and disorders such as Parkinson's disease, Huntington's disease, addiction, attention deficit hyperactivity disorder (ADHD), and depression is brain-derived …
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The Role of Substance P in Opioid Induced Reward
Chronic pain affects approximately 100 million Americans. Opioids are the mainstay therapy for the treatment of chronic pain. While physicians and patients alike are apprehensive about using opioids due to their side effects including respiratory depression and addiction, 259 million opioid …
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Stimolazione da etanolo del sistema dopaminergico mesolimbico: ruolo dell'acetaldeide
Evidence shows that acetaldehyde (ACD), the main metabolite of alcohol previously considered only a toxic substance, may actually mediates the reinforcing effects of ethanol (EtOH) (1). Accordingly, in rodents ACD is self-administred and stimulates the firing of Ventral Tegmental Area (VTA) …
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Exploration of cognitive and neurochemical deficits in an animal model of schizophrenia. Investigation into sub-chronic PCP-induced cognitive deficits using behavioural, neurochemical and electrophysiological techniques; and use of receptor-selective agents to study the pharmacology of antipsychotics in female rats.
… NMDA receptor antagonist, phencyclidine (PCP), is a psychomotor stimulant drug that has been shown to induce symptoms characteristic of schizophrenia in humans and animals. The aim of these studies was to use the sub-chronic PCP model in rats to investigate cognitive dysfunction in …
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Age-Related Alterations in Orexin Modulation of Septo-Hippocampal Neurotransmission
<p>Hypothalamic orexin/hypocretin neurons project widely to telencephalic regions influential in learning and memory, such as the hippocampus and the medial septum (MS) of the basal forebrain. Within the MS, orexin innervates cholinergic and GABAergic parvalbumin (PV) containing neurons that …
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Effect of medial prefrontal cortex 6-OHDA lesions on behavioral and neurochemical responses to gustatory stimuli
Appetitive sweet tastes increase dopamine (DA) in the nucleus accumbens (NAc) shell and core and in the medial prefrontal cortex (mPFC) in relation to their motivational valence, salience and novelty; the DA increase in the NAc shell is subjected to single trial habituation while in the NAc core …
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Analyzing peptide release using mass spectrometry
Neuropeptides are cell-to-cell signaling molecules that act as neurotransmitters, neuromodulators and hormones that impact a large variety of neuronal processes. The term neuropeptide refers to bioactive peptides made in neuron, stored in vesicles, and released into the extracellular space. While …
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Nucleus accumbens dopamine and investigatory behavior : modulation by the ventral subiculum of the hippocampus through the dopamine cell bodies of the ventral tegmental area
The nucleus accumbens septi (NAS) receives converging projections from both dopamine (DA) containing neurons of the ventral tegmental area (VTA) and glutamate containing neurons from the ventral subiculum (VS) of the hippocampus. VS projections to the NAS have been suggested to influence …
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Effect of antidepressants and adolescent stress on catecholamine transmission in the rat bed nucleus of stria terminalis (BNST): a microdialysis study
Rationale: Antidepressants include a relatively wide spectrum of drugs that increase the synaptic concentration of monoamines, mostly through neurotransmitter reuptake blockade. The bed nucleus of stria terminalis (BNST) is considered a relay station in mediating the activation of stress response …
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Neuropharmacological Mechanisms Underlying Incentive Salience and Stress
Anhedonia, the lost of interest or pleasure in normally enjoyable activities, is a core clinical feature of major depressive disorder (MDD). Although the term encompasses both consummatory and appetitive components, empirical findings suggest that anhedonia is more closely associated with deficits …
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The roles of αCaMKII and Ras-GRF2 in the establishment of drug addiction
Addiction is a chronic, relapsing disorder associated with health and social problems for the individual and great economic costs for society. Despite significant progress in the understanding of drug effects on the nervous system, major processes involved in the development of addiction are still …
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