Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"In Silico Modeling"”.
-
In Silico Modeling of Positive Pressure Ventilation: Assessing Therapy Safety, Performance and Efficacy
… è presente nell'allegato / the abstract is in the attachment
-
Challenging the Rigor of Alpha/Beta and Relative Biological Effectiveness in Tumor Contorl [sic] Probability Determinations via In Silico Modeling That Incorporates Individualized Biological and Physiological Data
BACKGROUND: Current methods for predicting the response of tumors to radiation therapy focus largely on linear quadratic (LQ) model survival parameters generated from conventional radiotherapy regimens, of ~2 Gy/fraction. The accuracy of the LQ model has been questioned for high dose per fraction …
-
STRUCTURAL INSIGHTS INTO POLYUBIQUITIN CHAIN FORMATION MEDIATED BY NEDD4 HECT LIGASE
NEDD4 is the founding member of a family of HECT E3 ubiquitin ligases which regulates the trafficking and stability of receptors and signaling proteins. Precise spatiotemporal control of its activity is essential for orchestrating cellular functions. In resting condition, NEDD4 N-terminus by …
-
Experiments and Simulations of Autonomous Microscale Robotics
Sub-millimeter microscale machines capable of navigating inaccessible spaces and remote locations are steadily approaching reality, with a rich literature emerging on externally actuated and supervised agents. In comparison, progress is slow towards autonomous, intelligent microscale agents. This …
-
Electrochemical Treatment of Tumors (EChT)
… treatment of cancerous tumors is a minimally invasive, versatile and relatively safe technology in which the direct electric current is changed to destructive reaction products by electrochemical reactions at electrode surfaces. It is believed that extreme cathodic and anodic pH …
-
Design, Synthesis, and Biological Screening of Novel Cucurbitacin/ Estrone Analogs Towards Treatment of Melanoma
<p>Cucurbitacins are highly oxygenated tetracyclic triterpene natural products. They are known for their broad spectrum biological activities. Cucurbitacins showed potential activity towards different cancer cell lines with lack of investigation of their activity towards treatment of melanoma. …
-
The Relationship between Linguistic Representations in Biological and Artificial Neural Networks
Research in cognitive neuroscience strives to understand the representations and algorithms that support human cognition, including language. The scientific tools for investigating human-unique capacities, such as language, have long been limited. For example, we do not have the option to learn …
-
Development of polymeric nanoparticle vaccines for immunostimulation
Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant gains in the understanding of the underlying mechanisms involved in developing …
-
In Vitro, In Vivo, and In Silico Studies of Reticulospinal Circuits and Generalized Arousal
… arousal (GA) is a fundamental force in the nervous system that alerts an individual to abrupt changes in its environment. A state of high GA is operationally defined by increases in an animal's a.) locomotor output, b.) responsiveness to sensory stimuli, and c.) emotional reactivity. …
-
Optimisation of insertion point during latissimus dorsi tendon transfer
Problem and Motivation: Posterior rotator cuff injuries are common (Yamaguchi et al., 2006), (Neri et al., 2009) and often debilitating and irreparable (Sim et al., 2001). Latissimus dorsi (LD) tendon transfers have been shown to be an effective treatment for these massive or irreparable tears …
-
Rapid methods for bacterial identification and predicting antibiotic resistance by MALDI-TOF MS
Since the 1990’s, there has been an exponential rate of growth of publications regarding mass spectrometry as a means for bacterial identification. The use of matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) as a high throughput, cost-effective alternative …
-
Hydrogen peroxide from photosynthesis: Theory and experiments linking elevated atmospheric CO2 with C3 plant chemical defense
… C3 plant chemical defense for reasons that remain unclear. To explain the influence of elevated CO2 on plant chemical defense, this dissertation proposes, then tests, the hypotheses that: 1. C3 plant chloroplasts exert control over chemical defense against biotic agents, and 2. the mechanism of …
-
Harnessing In Silico platform for Vaccine Discovery, Disease Modeling, and Immunotoxicity Prediction in Pandemic and Emergency Scenarios
… da pandemie ed emergenze, richiedendo soluzioni innovative per una gestione efficace. Questa tesi affronta problematiche di salute globale utilizzando strumenti computazionali avanzati per la scoperta di vaccini, la modellazione delle malattie e la previsione dell’immunotossicità. Integrando …