Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Impurity profiling"”.
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Studies in the synthesis and impurity profiling of pharmacologically active benzodifurans
… has the potential for considerable side-product/impurity formation. This project focused on synthetic strategies to benzofuran and benzodifuran derivatives in addition to their hydrogenated and substituted analogues. The chosen synthetic routes to target molecules further focused on the …
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Impurity profiling and synthesis of precursors to the hallucinogenic amphetamine DOB
… (LSD). To date, the work carried out on the impurity profiling of DOB is limited in comparison to amphetamine, methamphetamine and MDMA. In this work, the impurity profile of 4‐bromo‐2,5‐dimethoxyphenyl‐2‐propanone (4‐Br‐2,5‐P2P) is explored. This ketone is a direct precursor to DOB. Its more …
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Development of an analytical method for the organic impurity profiling of amphetamine
No abstract available.
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A comprehensive chemical examination of methylamphetamine produced from pseudoephedrine extracted from cold medication
… sample set for data interpretation. Organic impurity analysis was undertaken using a developed and validated GCMS impurity profiling method. The GCMS method discriminated the samples by synthetic route based on the presence of specific target impurities. Carbon, nitrogen and hydrogen stable …
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An investigation into the ability of three analytical techniques to discriminate batches of methlamphetamine prepared by seven synthetic routes
… using a developed and partially validated GCMS impurity profiling method. Basic and acidic impurities were extracted separately and analysed using a DB-1 MS column. The GCMS method discriminated all routes based on a set of route specific target impurities determined through this project. This …
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Using high resolution mass spectrometry to profile impurities in drugs from different sources
… with the molecule during purification processes. Impurity levels have to be controlled to conform to pharmacopoeial requirements; although this is less apparent in the case of organic and inorganic counterions. In the work reported in this thesis four applications of impurity profiling in APIs and …
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A study of the mechanism of hydrophilic interaction chromatography and its application in the analysis of medical drugs and metabolites
… the analysis of plasma and urinary metabolites, impurity profiling and in the separation of 'Legal high' regioisomers. An interest in the HILIC retention mechanism was mainly inspired by the need to understand how to develop the optimal HILIC conditions and the selection of a stationary phase. …
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The Synthesis and Chemical Profiling of 3,4-Methylene-Dioxymethamphetamine (MDMA) and Analogues
This work examines the organic impurity profiles of 3,4-methylenedioxymethamphetamine (MDMA) and its analogue methylone that were synthesised from uncontrolled ‘pre-precursors’. Methylone was synthesised from catechol by one synthetic route. Safrole was synthesised from catechol by two synthetic …