Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Imprinted gene"”.
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Molecular genetics of the imprinted gene - SPROUTY3 (SPRY3)
… regulators of cell growth and branching morphogenesis during development. Human SPRY3 which maps to the pseudoautosomal region 2, undergoes random X-inactivation in females and preferential Y-inactivation in males, behaving as though genetically X-linked. Spry3 is widely expressed in neuronal …
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Expression Analysis of the Imprinted Gene Transketolase-like 1 in Mouse and Human
<p>Genomic imprinting is an epigenetic phenomenon resulting in differential gene expression based on parental origin. Recently, <em>transketolase-like 1</em> (<em>TKTL1</em>) has been identified as an X-linked imprinted gene. TKTL1 functions in the nonoxidative branch of the pentose phosphate …
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Imprinted Gene Expression and Phenotype of Bovine Concepti with Bos taurus and Bos indicus Genetics
Epigenetic parent-of-origin effects contribute significantly to phenotypic variation in animals. Imprinted genes, which show differential allelic expression in a parent of-origin dependent manner, are critical regulators of prenatal development. Altered epigenetic modifications of imprinted genes …
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Investigating the impact of pharmacological exposures on the developing epigenome
Epigenetic processes are important for establishing and maintaining cell-type-specific and dynamic gene expression patterns. Genomic imprinting is an epigenetic process found in eutherian and metatherian mammals, which results in parent-of-origin specific expression. There are currently over 100 …
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Gene expression and imprinting in mice cloned by nuclear transfer
… inadequate reprogramming should lead to abnormal gene regulation in the clones, we have examined gene expression in clones to determine the extent of dysregulation and whether particular genes are commonly affected in clones. Abnormal imprinted gene expression has been proposed as a likely cause …
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Consequences of mitotic loss of heterozygosity on genomic imprinting in mouse embryonic stem cells
Epigenetic differences between maternally inherited and paternally inherited chromosomes, such as CpG methylation, render the maternal and paternal genome functionally inequivalent, a phenomenon called genomic imprinting. This functional inequivalence is exemplified with imprinted genes, whose …
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DNA methylation analysis and identification of a novel antisense transcript in the Peg3 imprinted domain
… that leads to the silencing of one allele of a gene in a parent of origin specific manner. Genes that are involved in this process are often regulated in clusters, one of which is the Peg3 (Paternally expressed gene 3) imprinted domain. We investigated this region for both CpG islands and long …
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Establishment of a phenotypical model of adverse outcomes associated with assisted reproductive technologies
… primarily as the result of the misregulation of imprinted genes associated with two clusters on chromosome 11p15.5, namely the KvDMR1 and H19/IGF2. There is a similar overgrowth phenotype that is observed in ruminants as a result of embryo culture. This syndrome is known as large offspring …
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The role of imprinting in embryonic development and tumorigenesis
… in the mono-allelic expression of a subset of genes depending on their parental origin. It is believed that DNA methylation marks are responsible for maintaining imprinted gene expression patterns. The 'parental conflict' hypothesis was proposed to explain the evolution of imprinting and is …
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Large offspring syndrome, a bovine model for the human loss-of-imprinting overgrowth syndrome Beckwith-Wiedemann
… associated with misregulation of two clusters of imprinted genes. Children conceived with the use of assisted reproductive technologies (ART) appear to have an increased incidence of BWS. As in humans, ART can also induce a similar overgrowth syndrome in ruminants which is referred to as large …
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Molecular Regulation of Maternal Hepatic Adaptations to Pregnancy
… a pregnancy-dependent role. We deleted the Ascl1 gene in the maternal liver using three independent mouse models from mid-gestation until term and identified multiple Ascl1-dependent phenotypes. When Ascl1 was deficient in maternal hepatocytes, maternal livers exhibited aberrant hepatocyte …
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Small RNAs within the developing seed of Arabidopsis thaliana
… thaliana exhibits a wide range of dynamic epigenetic phenomena, but relatively little is known about the small RNA (sRNA) populations found within the tissues composing the seed. We set out to profile the sRNA complement found within whole seeds and the embryo and endosperm tissues within the …
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Regulation of the Kcnq1ot1 Imprinting Domain in Mouse
Genomic imprinting is an epigenetic mechanism that controls gene expression based on parental-origin of an allele. The Kcnq1ot1 imprinting cluster consists of an imprinting control region (ICR), the Kcnq1ot1 ncRNA, and maternally expressed protein-coding genes. Truncation of the Kcnq1ot1 ncRNA or …
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The role of the Igf2/H19 locus in regulating murine placental endocrine capacity
… is a growth-promoting paternally expressed imprinted gene found in an imprinting locus with H19, a maternally expressed imprinted long noncoding RNA. In mice, manipulation of the expression of these genes or the differentially methylated imprinting control region (ICR1), which regulates …
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The epigenetics and role of Dopa Decarboxylase in heart development
… imprinting in mammals subjects a handful of genes to silencing on one allele depending on the parent-of-origin of that allele. The Ddc_exonla gene transcript is under the control of genomic imprinting in the developing and neonatal mouse heart with transcription occurring solely on the …
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Role of the atypical Notch ligand Dlk2, and it’s relationship with Dlk1 in mammalian neurogenesis
Mammalian neurogenesis is the process by which the central nervous system is formed. Neural diversity is generated by differentiation from neural stem cells (NSCs). In the embryonic murine brain, neuronal and glial cells are generated in the ganglionic eminence. In the postnatal brain, neurogenesis …
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… reasons are still not well understood. Epigenetic mechanisms are important regulators of gene transcription, which is a fundamental contributor to memory formation and consolidation and work to regulate the dynamic accessibility of DNA to transcriptional machinery, thereby controlling the …