Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Importins"”.
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Shield and Shuttle: Importins as Protective Chaperones and the Nuclear Transport Mechanism of H2A-H2B
… out by a sub-class of Karyopherins called Importins. It was hypothesized back in the early 2000s that importins could have dual functions as 1) nuclear importers and 2) molecular chaperones. This thought stems back to characteristics of importins: they are negatively charged and shuttle …
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Structural and Biochemical Studies of Multiple Importin-Histone Interactions
Multiple Importins can bind the N-terminal tails of histones H3 and H4, and import them into the nucleus to be assembled into the nucleosomes. However, it is not known what sequence elements in the histone tails are recognized by each of the Importins. Through structural and quantitative …
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Nucleocytoplasmic Localization of MAPKs
… require carrier proteins known as karyopherins (importins and exportins), ERK2 enters the nucleus of permeabilized cells even if these carrier proteins are missing. This is explained by direct binding to proteins in the nuclear pore complex (NPC). Similar to ERK2 targets, NPC proteins also …
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A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease
… signals promiscuously recognized by a variety of Importins were marginally, if at all, affected by Nup98 depletion, while export and import signals depending on Crm1 or Rae1 mediated RNA export were severely affected by the absence of full-length Nup98. We propose a novel cleavage mechanism for …
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Explorer l'impact de l'élimination de la charge nette cationique des signaux de localisation nucléaire (NLS) sur le ciblage par l'importine-α
… cells. Specialized transport proteins called importins recognize nuclear localization signals (NLSs) on proteins in the cytoplasm requiring nuclear entry. This biological phenomenon has spurred extensive research into NLS-tagged therapeutics to 8actively9 target the nucleus to maximize …
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Genetic, Biochemical, and Electron Microscopic Analysis of Components Involved in Transcription Coupled mRNA Export
… the mRNA export factors Sac3 and Mex67, with importins a and b, and with several nucleoporins, which are subunits of distinct subcomplexes of the NPC. This part of my studies indicated that the function of Gle2 is not restricted to nuclear export and suggested a more general role of Gle2 in …
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Dissecting the role of cathepsin V in breast cancer
… interacting with the nuclear transport proteins, importins. Additionally, nuclear cathepsin V has a role in the regulation of histone H3 and H4 protein expression by controlling the histone chaperone sNASP, which is an essential protein for histone H3-H4 reservoir formation. The reduction of …
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New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death
<p>Integrity of the human genome is frequently threatened by endogenous and exogenous DNA damaging reagents that may lead to genome instability and cancer. Cells have evolved multiple mechanisms to repair DNA damage or to eliminate the damaged cells beyond repair and to prevent diverse diseases. …
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The function of Nup358 in nucleocytoplasmic transport
Nukleocytoplasmatischer Transport erfolgt durch in der Kernmembran verankerte Porenkomplexe. Von einigen Nukleoporinen, den Komponenten der Kernporen, wird angenommen, dass sie eine Rolle als Andockstation für Transportkomplexe auf ihrem Weg in bzw. aus dem Kern spielen können. Das Nukleoporin …