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Showing 1 to 20 of 41 for “"Importin"”.

  1. Structural and Biochemical Studies of Multiple Importin-Histone Interactions

    Soniat, Michael Maurice, II2018

    Multiple Importins can bind the N-terminal tails of histones H3 and H4, and import them into the nucleus to be assembled into the nucleosomes. However, it is not known what sequence elements in the histone tails are recognized by each of the Importins. Through structural and quantitative …

    utswmed Repository record

  2. Importin [Beta]-mediated nuclear import pathways for DNA-binding proteins

    Forwood, Jade K2001

    aus-cath Repository record

  3. Importin [Beta]-mediated nuclear import pathways for DNA-binding proteins

    Forwood, Jade K2001

    anu Repository record

  4. Nuclear import of histone fold motif containing heterodimers by importin 13

    Walker, Patrick2012

    … signal- und energieabhängig über einen Importin 13 vermittelten Weg in den Zellkern importiert werden. Da die monomeren Untereinheiten CHRAC-15, CHRAC-17 und p12 nicht über ein funktionelles NLS verfügen, ist der nukleäre Transport abhängig von der Heterodimerisierung der jeweiligen …

    goettingen Repository record

  5. Charakterisierung des Kerntransportsystems von Linker-Histonen

    Baeuerle, Marc2012

    … H1-Histone vom Cytoplasma in den Kern wird durch Importin beta in Assoziation mit Importin 7 vermittelt. In dieser Arbeit konnte in in vitro Import-Assays mit permeabilisierten Eukaryontenzellen gezeigt werden, dass neben dem Importin 7/beta-Heterodimer keine weiteren funktionellen …

    goettingen Repository record

  6. Identification of <i>Phytophthora capsici</i> nuclear effector targets to bolster host immune signalling and resistance pathways

    Kulagina, NataljaUniversity of Dundee2018

    … targets.<br/><br/>In this work we Identified Importin α1 and α2 nuclear transporters as targets of P. capsici nuclear effector CRN1_719. In the effort to characterise these interactions we determined that Importin α1 and α2 may be implicated in nucleolar trafficking, have a role in plant …

    dundee Repository record

  7. Effects of vitamin D on pro-inflammatory cytokines associated with Non-alcoholic fatty liver disease

    Ayouk, Nypiat MartinCreighton University2016

    … increase mRNA and protein expression of importin-α3 and cyp24A1 and significantly decrease mRNA and protein expression of VDR, IκBα, and cyp27B1 in HepG-2. Treatment of HepG-2s with calcitriol significantly decrease mRNA and protein expression of importin-α3 and attenuate the effects of …

    creighton Repository record

  8. Design of an in vitro assay to optimize assembly of nanoparticle-tagged nuclear import complexes

    Rosenbaum, Lara EliseMassachusetts Institute of Technology2007

    … binding partners. Two chaperone proteins, importin-a and importin-3 mediate classical nuclear transport, an essential and highly conserved example of protein complex formation in eukaryotic cells. Together, these two proteins form a chaperone complex that recognizes a nuclear localization …

    mit Repository record

  9. Shield and Shuttle: Importins as Protective Chaperones and the Nuclear Transport Mechanism of H2A-H2B

    Jiou, Jenny2025

    … out by a sub-class of Karyopherins called Importins. It was hypothesized back in the early 2000s that importins could have dual functions as 1) nuclear importers and 2) molecular chaperones. This thought stems back to characteristics of importins: they are negatively charged and shuttle …

    utswmed Repository record

  10. Vitamin D and Immunomodulation in Bronchial Asthma

    Agrawal, TanupriyaCreighton University2012

    … of NF-κB are translocated to the nucleus by importin α3 and importin α4. The potent immunomodulatory role of Vitamin D in both innate and adaptive immunity has recently been appreciated. Calcitriol exerts its action through the Vitamin D receptor (VDR), which is a high affinity nuclear …

    creighton Repository record

  11. Explorer l'impact de l'élimination de la charge nette cationique des signaux de localisation nucléaire (NLS) sur le ciblage par l'importine-α

    Abdoli, AmirabbasUniversité de Sherbrooke2024

    … cells. Specialized transport proteins called importins recognize nuclear localization signals (NLSs) on proteins in the cytoplasm requiring nuclear entry. This biological phenomenon has spurred extensive research into NLS-tagged therapeutics to 8actively9 target the nucleus to maximize …

    sherbrooke Repository record

  12. The function of Nup358 in nucleocytoplasmic transport

    Wälde, Sarah2012

    … von Proteinen, die entweder durch den Importin α/β-Komplex (Hutten et al., 2008) oder durch Transportin (Hutten et al., 2009) importiert werden. Somit könnte Nup358 als eine allgemeine Andockstation für spezifische Transportkomplexe fungieren. Um die Spezifität des beobachteten Effekts …

    goettingen Repository record

  13. Deciphering the mechanism by which humanin binding to IGFBP3 inhibits neuronal cell death in alzheimer’s disease

    Njomen, Evert2014

    <p>Nuclear translocation of IGFBP3 by importin β1 is a prerequisite for apoptosis induced by IGFBP3 in Alzheimer’s disease (AD). The neuroprotective peptide humanin (HN) counteracts this IGFBP3-induced cell death. Unfortunately, the natural synthesis of this peptide decreases with age coincident …

    emich Repository record

  14. Feedback Regulation of Wnt Signaling by Naked Cuticle (Nkd) During Drosophila Embryogenesis

    Chan, Chih-Chiang2010

    … of Nkd's role in the nucleus, Nkd binds to Importin-alpha 3, an adaptor for the canonical nuclear import apparatus. I identified that Nkd associates with Importin-alpha 3 via a motif ("D6") that is conserved between D. melanogaster and D. pseudoobscura. NkdΔD6, lacking the Importin-alpha …

    utswmed Repository record

  15. Localization and Stability of the Transcriptional Activator Gcn4p of Saccharomyces cerevisiae

    Pries, Ralph2012

    … Untersuchungen verschiedener S. cerevisiae Importin-Mutantenstämme haben verdeutlicht, dass Importin a Srp1p und Importin b Kap95p fr den Kerntransport von Gcn4p erforderlich sind. Des weiteren war es ein Anliegen dieser Arbeit, die Regulation der Proteinstabilität von Gcn4p zu untersuchen. …

    goettingen Repository record

  16. Strukturelle und funktionelle Untersuchungen zum m3G-Cap-vermittelten Kernimport spleißosomaler U snRNPs durch Snurportin1

    Strasser, Anja2012

    … snRNPs und dem Kernimportrezeptor Importin beta, der die Kernporenpassage mediiert. SPN1 besteht aus einer N-terminalen Importin beta-bindenden (IBB)-Domäne und einer C-terminalen m3G-Cap-bindenden Domäne, die keinerlei Sequenzähnlichkeit zu anderen Proteinen aufweist.In der …

    goettingen Repository record

  17. The role of Pcl5p and Pcl7p in the Gcn4p stability regulation of Saccharomyces cerevisiae

    Schulze, Florian2012

    … abhängig ist und vermutlich durch das β-Importin Kap95p vermittelt wird. Für die von der Aminosäureversorgung abhängige Stabilisierung von Gcn4p sind der Zyklin-abhängige Kinase Inhibitor Pho81p, sowie ein weiteres Zyklin, Pcl7p, notwendig. Es wird angenommen, dass die Stabilisierung von …

    goettingen Repository record

  18. Charakterisierung der viralen Genprodukte p10 und P des Borna Disease Virus

    Unterstab, GunhildUniversität Potsdam

    … zeigten, dass p10 über den klassischen Importin alpha/beta abhängigen Kernimportweg in den Nukleus transportiert wird. Dies war unerwartet, da p10 kein vorhersagbares klassisches Kernlokalisierungssignal (NLS) besitzt und weist darauf hin, dass der zelluläre Importapparat offensichtlich …

    potsdam-diss Repository record

  19. The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal

    Chaudhary, Shubhash Chandra2015

    … of the c-Met fragment and its association with importin β, the carrier protein. The putative NLS of c-Met is unique in that it relies on histidines, whose positive charge changes depending on pH, rather than the lysines or arginines, commonly found in classical bipartite NLSs, suggesting the …

    ajou Repository record

  20. Faktoren des Kerntransports von Core-Histonproteinen: Strukturelle und funktionelle Analyse

    Baake, Matthias2012

    … werden. Rekonstitutionsstudien identifizierten Importin-beta, Importin5, Importin7 und Transportin als funktionelle Importrezeptoren für den Kernimport der Core-Histone.

    goettingen Repository record

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