Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Implantable Drug Delivery"”.
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An intraperitoneal implantable drug delivery device for the treatment of ovarian cancer
… catheter-related complications and simplifies IP drug administration would therefore allow more patients to enjoy the benefits of IP therapy. A drug delivery device for use in a mouse model was developed as a tool to prove that maintaining a low constant cisplatin concentration in the peritoneal …
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Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device
The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release profiles in order to maximize the effectiveness of drug therapies. It …
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Fabrication of drug delivery MEMS devices
… on the battlefield. A novel approach to drug delivery on the battlefield based on MEMS technology is discussed. By combining three separately fabricated layers, a single implantable drug delivery device capable of delivering up to 100 mm3 of a vasopressin solution was developed. In vitro …
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A histological and immunological response study of an implantable microcapsule drug delivery device for the treatment of glioblastoma
… toxicity associated with many chemotherapeutic drugs. Advances in implantable drug delivery devices look promising, but can suffer from the possibility of biofouling, or loss of function due to a patient's own immune response. An implantable microcapsule device, designed to deliver locally …
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Microcapsule drug delivery device for treatment of glioblastoma multiforme
Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. The use of drugs capable of crossing the blood-brain barrier has shown modest …
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Development of biodegradable implants for sustained drug delivery
The advent of sustained drug delivery has resulted in many patient benefits including reduced frequency of drug administration and reduced side effects. Implantable drug delivery benefits from these advantages, but importantly, can be removed if adverse effects necessitate it. In this thesis, …
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Development of a Novel Drug Delivery System Based on Conducting Polymers
… over conventional therapies by maintaining drug concentrations at therapeutically desired levels whilst simultaneously improving compliance. Intrinsically Conducting Polymers (ICP) are organic materials that have electrical, magnetic and optical properties usually associated with metals, …
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Development of implantable devices for schizophrenia treatment
… of neurotransmitters in the brain. One of the drugs that is commonly prescribed to treat schizophrenia is risperidone (RIS). This drug is administered through the oral route (e.g. tablets). Accordingly, the drug is exposed to first-pass metabolism and enzymatic degradation in the …
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Engineering electroresponsive layer-by-layer thin films
… as model systems for electrically triggered drug delivery applications and "mechanomutable" surface coating applications. Two strategies were implemented in the design of these electroresponsive films: the use of redox-active, chargeshifting nanoparticles and the control over local pH …
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Development of an electrostatic peristaltic gas micropump and nanochannel fabrication technique
… such as micro total analysis systems (μTAS), implantable drug delivery system for high precision flow control, microchips integrated into computers to circulate coolant, as well as micro pumping for portable gas chromatography (GC) system. In a microfluidic system, the micropump is an …
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Conducting polymer hydrogels for the release of glutamate and sensing of extracellular action potentials
… including oral and systemic administration of drugs have limited ability to cross the blood brain barrier and hence require frequent administration of drugs in higher doses leading to unwanted side effects. Recent advances in the field of drug delivery have made it possible to release drugs …
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Advancing Next-Generation Active Implantable Medical Devices - System Design and Integration for Long-Term Therapeutic Applications
L'abstract è presente nell'allegato / the abstract is in the attachment