Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"Imp"”.
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Identification and characterization of a small molecule inhibitor of IMP-1 that decreases expression of IMP-1 target mRNAs and inhibits proliferation of IMP-1 positive cancer cells
… Growth Factor-2 mRNA-Binding Protein 1 (IGF2BP1/IMP-1/CRD-BP). IMP-1 exhibits an oncofetal pattern of expression, where it is expressed in embryonic development and its expression is repressed shortly after birth. However, the IMP-1 gene is reactivated in many different human cancers. …
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Plasma studies with the IMP-2 satellite.
Massachusetts Institute of Technology. Dept. of Electrical Engineering. Thesis. 1966. Ph.D.
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Mechanistic Basis of Signal Amplitude Modulation by the Ras Effector IMP
… The Ras effector and E3 ligase family member IMP (Impedes Mitogenic signal Propagation) acts as a steady-state resistor within the RAFMEK- ERK kinase module. IMP concentrations are regulated by Ras, through induction of autodegradation, and can modulate signal/response thresholds by directly …
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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
… two separate metallo-β-lactamase enzymes, first IMP-1, which provides antibiotic resistance to Pseudomonas aeruginosa, and second Bla2, which grants antibiotic resistance to Bacillus anthracis. The main focus of this work was to investigate and characterize IMP-1 according to its activity and …
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Functional characterization of the role of Imp, a Drosophila mRNA binding protein, during oogenesis
… in certain vertebrate systems. Identification of Imp, the Drosophila member of the VICKZ family, opened the possibility to use genetic approaches to investigate the roles of a VICKZ family member in mRNA localization and translational control. In this dissertation, we show that Imp is associated …
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Analysis of the role of Drosophila IMP in actin mRNA localization and cell migration
IMP is a conserved RNA binding protein involved in vertebrate cell migration and cancer metastasis. Drosophila IMP is required for border cell migration and follicle cell morphogenesis during oogenesis. Later on, imp null embryos do not complete embryogenesis and fail to undergo dorsal closure. One …
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The Idea Melting Pot (IMP) : an openly-editable web-based community learning resource for builders
… and designs [Lifelong Kindergarten, 2007]. The IMP differs from existing resources in three key ways. First, by allowing for both project pages and concept pages to be added and by providing numerous, flexible ways of navigating the site, the IMP attempts to treat learning through construction …
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A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
… to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of …
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Uncovering the Complexity of RAS Signaling Networks
… oncogenic transformation. Here we describe two important aspects to understanding the signaling complexity of any multiphenotypic arrangement, namely, the identification and examination of new effectors and the direct authentication of protein-protein interactions. We have identified a new Ras …
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X-ray crystallographic studies of the nucleotide binding sites on adenylosuccinate synthetase mutants from Escherichia coli
… presented in this work contain 6-phosphoryl-IMP, GDP, and Mg⁺². The K 16Q and R 143 L mutants have hadacidin bound, whereas R3 03 L has only water molecules in the putative aspartate binding site. As a consequence the 300's loop is disordered in the R3 03 L structure. In the K 16Q structure, …
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Purine Degradation and Ureide Catabolism by Soybean (Glycine Max (L.) Merrill); Cell Suspension Cultures
… acid and inosine-5$\sp\prime$-mono- phosphate (IMP), as sole nitrogen sources. The inhibitors of purine degradation, allantoxanamide and allopurinol, caused accumulation of uric acid and hypoxanthine, respectively, in cell suspensions fed radiolabelled IMP and effectively blocked growth on IMP, …
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Studies on the mechanism of action of thyroid hormones
Inosine monophosphate (IMP) is a precursor of the two purine nucleotides, adenosine monophosphate (AMP) and guanosine monophosphate (GMP)e through DEAE-Scphacex, and the reaction IMP~ XMP is catalyzed by: IMP dehydrogenase which was purified in a manner similar to adenylosuccinate synthetase. …
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Molecular Characterization of Inositol Monophosphatase Like Enzymes in Arabidopsis thaliana
… molecules. myo-inositol monophosphatase (IMP) is a major enzyme required for the synthesis of myo-inositol and breakdown of inositol (1,4,5)-trisphosphate (InsP3), a potent second messenger involved in many biological activities. Arabidopsis contains a single canonical IMP gene, which was …
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Seismic data decomposition using sparse dictionary
… iteration for thin layer reservoirs. The improved MP (IMP) algorithm assumes that the seismic reflection response of thin layers can be simulated by the convolution between wavelet and a thin-layer cake model. The parameters of wavelet library of MP algorithm include wavelet type, the …
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Formally Verified Code Obfuscation in the Coq Proof Assistant
… by using the Coq Proof Assistant and IMP (a simple imperative language within it), to formulate what it means for a program's semantics to be preserved by an obfuscating transformation, and give formal machine-checked proofs that these properties hold. We describe our work on opaque …
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Analysis of the electron transport properties in quantum cascade lasers
… highly temperature sensitive and increases the importance of scattering processes which favor small transition energies, such as electron-electron (e-e), electron-impurity (e-imp)and electron-interface roughness scattering. This thesis details the development and calculation results for …
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Investigation of Biofilm Development by Antibiotic Resistant Urinary Tract Infection Pathogens and Evaluation of the Antimicrobial Activity of Natural Products on Carbapenem-Resistant Escherichia coli IMP and Klebsiella pneumoniae NDM-1.
… of existing therapeutics that are able to impact, at least partially, the bacterial biofilm. Aims The aim of the study is to understand the different stages in the formation and development of biofilms in Escherichia coli IMP and Klebsiella pneumoniae NMD-1 in different growth media and …
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The oligomerisation of propene over nickel oxide silica alumina
… alumina catalysts prepared by the techniQues of impregnation (IMP) and co-precipitation (SG). Amongst others. the effect of the nickel content. reacti6n temperature and pressure, and water content of the feed, on the activity and selectivity. were investigated. Also investigated were the lifetime …
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The effects of chemical composition, solidification rate, and homogenization on the intermetallic particle microstructure of AA8XXX aluminum alloys for battery foil applications
… the Al-Fe-Si system, show promise due to their improved strength. However, their intermetallic particle (IMP) microstructure needs to be understood for optimal performance. This research investigates the impact of chemical composition, cooling rate, and homoge- nization processes on the IMP …
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An in vitro system for studying the mechanism of action of thyroid hormones
… rat liver homogenates, in the presence of IMP as a precursor of purine nucleotides and necessary substrates, stimulated orotic acid-6-¹⁴C incorporation into nuclear RNA. The stimulatory effect was observed with 10⁻⁹ M triiodo-L-thyronine (L-T₃ )and with 10⁻⁵ M thyroxine. Thyroid hormones …
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