Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Immunotherapy resistance"”.
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
Resistance to immune checkpoint inhibitors (ICIs) remains a critical barrier to effective cancer therapy, driven by complex, multi-scale interactions that current biomarkers often fail to capture. This dissertation introduces the Biologically Disentangled Variational Autoencoder (BDVAE)—an …
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Tumor Immunotherapy: Mechanisms of Acquired Resistance and Characterization of Immune Related to xicities
<p>Tumor immunotherapy has shown very promising clinical benefit across an array of cancers; however, two major challenges remain unresolved in the field. First, many patients do not respond to therapy at all or relapse after a period of remission. Second, there are often dose-limiting immune …
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Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression during Immunotherapy
… pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral heterogeneity in influencing immune interactions. Using orthotopic clonal replica tumors, we tracked clonal dynamics in response to anti-PD1 …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… show limited efficacy in HGSC, with no approved immunotherapy options for patients. This is due to an immunosuppressive tumor immune microenvironment (TIME) that limits the efficacy of ICB. Resistance to immunotherapy is driven in part by TGF-β signaling in the ovarian TIME, leading to immune …
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Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
… immunoediting in carcinogenesis, metastasis and immunotherapy resistance makes understanding the mechanisms of immunoediting essential in informing cancer therapy and prevention. Previous work on immunoediting has largely focussed on neoantigen loss, but this thesis aimed to expand the …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… stroma, severe immunological suppression, and resistance tostandard treatments. The need for innovative therapeutic approaches is highlighted by the tumor microenvironment's (TME) critical role in promoting disease development and reducing the effectiveness oftreatment. A promising locoregional …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
Resistance to cancer therapy is common and understanding mechanisms of resistance is critical to drive development of next generation therapies. We demonstrate that cancer cells co-opt anti-viral signaling to sustain genetic programs that drive resistance to multiple anti-cancer modalities. In the …
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Computational dissection and prediction of cancer immunotherapy response
… vesicular (EV) RNA as a potential biomarker for immunotherapy response. We discover differentially expressed genes and pathways within the plasma-derived EV RNA that is concordant with known biology. We also show that mutational information contained within EV RNA can stratify responders and …
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Applications of forward genetic screens to LncRNAs, cancer immunotherapy, and cellular engineering
… four neighboring genes, one of which conferred resistance to a melanoma therapeutic. We next sought to use CRISPR activation screening to gain insight into the cellular processes that govern tumor resistance to immunotherapy. We identified four candidate genes in our screen, which we validated …
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Advancing T Cell–Based Immunotherapies: Identification of Tumor-Specific T Cell Receptor Targets and Mechanisms of Resistance in Solid Tumors
… and the development of tumor-intrinsic immune resistance mechanisms that enable evasion of immune surveillance. Overcoming these challenges will be critical to enhance the effectiveness of cancer immunotherapies and improve patient outcomes.</p> <p>Anaplastic thyroid cancer (ATC) is one of the …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… (MASH) has created a major challenge for cancer immunotherapy. Individuals with these conditions face higher cancer incidence and respond poorly to immune checkpoint inhibitors and cellular therapies. Rather than acting solely on tumors, metabolic dysfunction dismantles antitumor immunity both …