Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 632 for “"Immunotherapy"”.
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Immunotherapy in multiple myeloma
… therapies for MM, and suggest that a combined immunotherapy approach using pre-stimulated T cells, MM Ag primed DC and IL-2 may produce better clinical responses in MM patients.
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Immunotherapy for murine glioma
Oncolytic viral immunotherapy is a novel approach to cancer treatment. Viruses can directly kill cancer cells, provide antigens to dendritic cells to stimulate a T cell response, and make cancer cells express genes of immune-enhancing cytokines locally within the tumor microenvironment. We …
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Integrin-targeted cancer immunotherapy
… as a target tumor antigen in the context of immunotherapy. The engineered cysteine knot peptide, 2.5F, is highly crossreactive and capable of recognizing multiple RGD-binding integrins. Our initial attempts to utilize this binder as a targeting moiety for delivering IL-2 as an immunocytokine …
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Novel immunotherapy for paediatric cancers
Chimeric antigen receptors (CAR) are synthetic receptors that redirect T lymphocytes to specific tumour antigens. CART cells targeting CD19 (CAR19) have demonstrated remarkable efficacy against B cell malignancies in clinic. Currently used methods of CAR gene transfer to T cells based on viral …
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T cell mediated combination immunotherapy
Immunotherapy is a broad treatment strategy that harnesses the immune system to fight off a particular condition or disease. Cancer immunotherapy is the specific application of agents designed to interact or stimulate the immune system to fight off tumors. Treatments as diverse as passive antibody …
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Antibody engineering for tumor immunotherapy
Antibodies have been used as cancer therapeutics for several decades. One area in which this therapy may be improved is the retention time of antibody in the tumor relative to normal tissue. In this Thesis, we have attempted to elucidate the mechanisms that are most influential to improving …
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Plasmacytoid dendritic cells & immunotherapy of cancer
Item does not contain fulltext
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Immunotherapy of Folate Receptor Expressing Cancers
The folate receptor (FR) is a GPI anchored cell surface glycoprotein that functions to facilitate folic acid uptake and mediate signal transduction. With the introduction of multiple folate-targeted drugs into the clinic, the question has arisen regarding how frequently a patient can be dosed with …
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
Inducing and maintaining a long-lived potent cellular CTL (Cytotoxic T Lymphocyte) response is of significant interest to the global scientific community. Protection against most intracellular pathogens (e.g., HIV) and tumors require functional CTL immunity and are ineffectively treated by …
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Interpretable Modeling of Immunotherapy Response Factors
Immunotherapy, which treats cancer by either stimulating or suppressing the immune system, has been extraordinarily effective for some cancers, such as breast cancer and B-cell lymphoma. A type of immunotherapy, checkpoint inhibitors work by blocking the ability of cancer cells to evade immune …
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Cancer immunotherapy with Mucin-1 and cytokines
Cancer immunotherapy involves the manipulation of the immune response to combat tumour cells. The studies contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, …
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Radiographic Challenges and Considerations with Cancer Immunotherapy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Precision Medicine in Immunotherapy and Lung Cancer
… treatment such as platinum chemotherapy or immunotherapy for non-small cell lung cancer, and combines potential biomarkers from simple immunohistochemistry to advanced single-cell RNA sequencing data to predict immunotherapy toxicity. Outline The first chapter of this thesis explores the …
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Experimental brain tumors, dendritic cells and immunotherapy
… loading or maturation methods compared to immunotherapy with IFN-γ-producing tumor cells. In conclusion, we have demonstrated that DC-based vaccines fail to provide protection in a weakly immunogenic brain tumor model but do enhance the anti-tumor immune responses elicited by …
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Engineering dendritic cells for enhanced cancer immunotherapy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Engineering persistent interleukin-2 for cancer immunotherapy
… such as surgery, radiation, and chemotherapy, immunotherapy offers the possibility of systemic yet tumor-specific cell killing as well as long-lasting cancer protection. A significant mode of tumor rejection is direct tumor cell killing by immune cells, such as cytotoxic T lymphocytes (CTLs) …
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Yeast-based vaccine approaches to cancer immunotherapy
… and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful induction of cellular immunity. Using a yeast vaccine model, we investigated the phagosome-to-cytosol pathway of …
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Improving methods for cytokine immunotherapy of cancer
… Numerous studies have identified cancer immunotherapy combinations that exhibit synergistic antitumor activity, but surprisingly, these studies rarely consider the effects of relative dose timing. In the second part of this work, using established syngeneic tumor models, we found that …
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