Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Immunotherapeutic strategies"”.
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Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… the potential of L1CAM as a target for immunotherapeutic therapies, with L1CAM-ADC demonstrating effective immunotherapeutic approach in therapy of even advanced PDAC.
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Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
… associated immunosuppression, by investigating strategies to facilitate the maturation of immature immune cells. We considered different commercially available toll like receptor (TLR) agonists namely Pam3CSK4 (Pam), Poly (I:C), lipopolysaccharide, FLA-ST, FSL-1 and R848, and compared their …
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T Cell Exhaustion in Glioblastoma
… a significant need for newer treatment strategies such as immunotherapy. Immune checkpoint blockade is a type of immunotherapy which seeks to perpetuate T cell activity by blocking inhibitory immune checkpoints. This strategy has gained FDA approval in several solid tumors, yet has …
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UNCOVERING IMMUNE EVASION MECHANISMS FOR THE PROGNOSIS AND THERAPY OF ENDOMETRIAL AND OVARIAN CANCERS
… and clinical studies are ongoing with immunotherapeutic strategies combined or not with classic treatments. To date, the efficacy is not satisfactory, thus a detailed understanding of the biology and interactions between cancer and the immune system is essential for the recognition and …
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Bi-directional tumour-host interaction in a murine model
… that this work would eventually lead to improved immunotherapeutic strategies. The primary objective of the work was to study the mechanisms by which tumours of differing origins and antigenic spectra circumvent the anti-tumour immune response to grow and develop. Responses were characterised for …
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Clinical Relevance of Immune Cells in Pancreatic Adenocarcinoma and their Implication in Immunotherapy
… of human PDAC and foster the introduction of immunotherapeutic strategies into the clinical practice. The first section of the thesis summarizes the work done to investigate the occurrence of tertiary lymphoid tissue (TLT) in PDAC. TLT has been demonstrated to coordinate the recruitment and …
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Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models
… providing valuable insights for developing novel immunotherapeutic strategies to improve patient outcomes.
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
… our findings suggest that iNKT cell-based immunotherapeutic strategies could co-opt these unique features of iNKT cells to improve their efficacy and longevity of anti-tumor responses, a critical need for the field of cancer immunotherapy.
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Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
… the basis for the rational design of novel immunotherapeutic strategies and increasingly effective vaccines.
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Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
… in tumors and lymph nodes. Combination strategies using Flt3L-LNPs with immune checkpoint inhibitors and AC-NPs showed robust antitumor responses, achieving >50% tumor-free survival and indicating the promise of replacing adoptive cDC1 transfer. Collectively, this thesis demonstrates …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… and thus, potentially useful vectors for immunotherapeutic strategies. Importantly, autophagy promotes the presentation of self and foreign antigens for activation of immune cells. Our data demonstrated for the first time that adenoviral epitopes were presented at the surface of cells …
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Modulatory effects of GluN1 autoantibodies on brain function
… as supported by findings in vaccination strategies for Alzheimer’s disease (AD) in mouse models and autoimmune disease models. Our laboratory has previously shown that naïve rats vaccinated against the GluN1 subunit of the N-methyl-D-aspartate (NMDA) receptor developed high anti-GluN1 …
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Identification of candidate tumour antigen peptides with immunogenic potential for use in cancer immunotherapy
… peptides in order to formulate more effective immunotherapeutic strategies. As such, the aim of this study was to identify novel MHC class II HLA-DR1 and HLA-DR4 restricted immunogenic peptides derived from the MART-1 and Tyrosinase tumour antigens. A computer algorithm (SYFPEITHI; available on …
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Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… of toll-like receptor agonists as an immunotherapeutic for canine osteosarcoma. From a comparative and translational perspective, the long-term goals of this research include not only the treatment of canine osteosarcoma, but also human osteosarcoma, as this disease has numerous …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… innovation, by paving the way for novel immunotherapeutic strategies specifically targeting IC-resistant CRLM.
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… providing new insights for optimizing immunotherapeutic strategies.
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NOVEL MONO-, BI- AND TRI-SPECIFIC IMMUNOMODULATORY ANTIBODIES FOR CANCER THERAPY AND TOOLS FOR OTHER THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
… of death worldwide, and the development of novel immunotherapeutic strategies, such as that of immune checkpoint inhibitors (ICIs), has generated long-lasting responses in multiple malignancies. Even though safer than chemotherapies, some adverse events, including rare cases of cardiotoxicity, …
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Visualizing The Dynamics of Immune Surveillance In Brain Tumors By Intravital Multiphoton Microscopy
… a bad prognosis despite conventional treatment strategies. Immunotherapy is a relatively novel treatment approach that has shown benefit for durable treatment of melanoma, and is a promising candidate for different tumor types including BTs. Immunotherapeutic strategies work by exploiting and/or …