Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Immunosurveillance"”.
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T Cell Immunosurveillance in Pancreatic Ductal Adenocarcinoma
ABSTRACT T CELL IMMUNOSURVEILLANCE IN PANCREATIC DUCTAL ADENOCARCINOMA Rebecca A. Evans Robert H. Vonderheide The prevailing theory of cancer immune surveillance, as understood from carcinogen-driven mouse models of highly mutated tumors, states that T cell-mediated immune pressure drives a …
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Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
The phytoestrogen genistein has attracted a great deal of recent interest. In MCF-7 cells, we find that 10 nM genistein induces PI-9 as effectively as saturating E2, and genistein treated MCF-7 cells are resistant to NK cell mediated cytotoxicity. In ERalphaHA cells, the dose response curves for …
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Upper-respiratory infection triggers experimental autoimmune encephalomyelitis onset in autoimmune prone t-cell receptor transgenic mice
… in the choroid plexus. Finally, we observed immunosurveillance of the brain by T-cells and CD45highCD11b+ cells in C57BL/6 mice after influenza inoculation. This immunosurveillance could prove detrimental to MS patients.
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The Role of the Mismatch DNA Repair Protein MutL in Antigenic Variation of the Lyme Disease Spirochete
… recombinational switching system to avoid immunosurveillance in a vertebrate host using MutL.
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Markers of immunosenescence and oxidative stress in healthy adults
… in lymphocyte sub-populations important for immunosurveillance. This exercise also resulted in increased markers of oxidative stress in lymphocytes, and resulted in a whole body oxidative stress, which was more pronounced and prolonged, following ultra-endurance exercise. Studies also showed …
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Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
… of macrophages enable tissue invasion during immunosurveillance and wound healing. Using model THP1 macrophages, my studies have shown that Tks5 can directly control podosome-associated matrix degradation and invasion through collective changes in adhesion, chemotaxis, and the …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… a hitherto unknown role in tumorigenesis and immunosurveillance of cancer.
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Immune modulating functions by soypeptide lunasin in cancer immunotherapy
… relapse or suffer progression of the disease. Immunosurveillance is capable of recognizing and eliminating continuously arising transformed mutant cells, and thus cancer immunotherapy is one of the emerging therapeutic strategies that harnesses the power of the immune system to eradicate …
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Engineered models of the lymphatic stroma to study cell and fluid transport
… essential roles in regulating fluid balance and immunosurveillance. Across the body, local lymphatic vessels collect waste in the form of lymph and deliver it to nearby lymph nodes (LNs) to be filtered and screened for pathogens. With broad implications in adaptive immunity, cancer metastasis, …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
… uncover a potential role for CCR2 in the optimal immunosurveillance of damaged or stressed peripheral tissue during sterile inflammation. Further investigation into the requirement for host CCR2 in protection from influenza infection revealed a cell-extrinsic requirement for CCR2 in optimal memory …
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The Biological and Immunological Effects of Irreversible Electroporation and Combination Therapy Options for the Improving the Treatment of Pancreatic Cancer
… for presentation to induce local and systemic immunosurveillance. However, these effects are limited by countering expression of programmed-cell death ligand 1 (PD-L1), a checkpoint protein that inhibits cytotoxic lymphocyte activity and allows the tumors to recur. The effects of IRE can …
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Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system
… of IELs patrolling along the epithelium to the immunosurveillance of the guts. However, little is known about how these immune cells move.<br/><br/>Intestinal organoids are three-dimensional structures of epithelial cells that mimic the gut epithelium in vitro. In this study a murine …
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
… leading to the escape of melanoma cells from immunosurveillance. Our previous study suggests that neuronal nitric oxide synthase (nNOS)-mediated nitric oxide (NO) signaling is crucial for melanoma progression and forms a mechanistic rationale behind nNOS inhibition as a novel treatment …
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The Biology of Mantle Cell Lymphoma: Exploring the Gender Difference in Mantle Cell Lymphoma
… to male MCL patients. The concept of cancer immunosurveillance is well described and it is perceived that females mount a greater immune response compared to males. In addition, although lymphomas are generally not perceived to be hormone controlled, epidemiological studies have demonstrated …
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Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
… suggested that Brd7 loss hindered effective immunosurveillance. ATAC-seq revealed wide-spread shifts in chromatin accessibility upon Brd7-loss, while ChIP-seq demonstrated alteration of H3K27ac labeling at thousands of genomic sites, with Brd7-loss exhibiting reduced H3K27ac binding at …
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A Clonal, Transcriptomic, and Functional Analysis of T-cells Mobilized to Blood in Response to Acute Exercise
… induced by acute exercise over time, may improve immunosurveillance against viral pathogens, providing beneficial anti-viral effects. While exercise has been shown to promote anti-viral immunity, the mechanisms by which exercise can ameliorate symptoms and enhance synthetic immunity against …
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Investigating couplet strategies incorporating 4 pillars of cancer therapy
… immune response may then exert body-wide immunosurveillance to delay or prevent metastatic progression.
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The impact of cholesterol and its metabolites on the ovarian tumor microenvironment and cancer progression
… that 27HC was associated with compromised immunosurveillance. Specifically, CYP27A1/27HC-axis altered the recruitment of 1) monocytic-MDSCs, an immunosuppressive subtype of myeloid cells, 2) antigen-presenting myeloid cells, and 3) CD4+ T cells. In addition, bone marrow from wildtype mice …
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