Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Immunosuppressive therapy"”.
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Changes in peripheral B cell subsets under immunosuppressive therapy
… with special emphasis on changes induced by immunosuppressive therapy (disease modifying antirheumatic drugs (DMARDs)) and cyclophosphamide (CYC) treatment. There was a significant impact of immunosuppressive treatment on peripheral B cell subsets in SLE and WG patients. Absolute lymphocyte …
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Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation
… allogeneic bone marrow transplantation (BMT) or immunosuppressive treatment in severe aplastic anemia (SAA) and identified prognostic factors related with survival. METHODS: Medical data of SAA patients who treated with BMT or immunosuppressive therapy (IST) at the Ajou University Hospital from …
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Development of a rapid diagnostic screen for telomerase mutations associated with immunosuppressive therapy failure in patients with aplastic anaemia
Includes abstract. Includes bibliographical references.
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Gene therapy studies of Adenoviral IL-10 transduced Dendritic cells in allotransplantation / by Toby Coates.
… capacity of dendritic cells transduced with the immunosuppressive gene construct adenoviral interleukin-10 to inhibit alloimmune responses in both small and large animal transplantation models. There is promising in vitro evidence for gene therapy to modify dendritic cell function, which in small …
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Gliotoxin Production in Aspergillus fumigatus
… to the increasing number of patients undergoing immunosuppressive therapy and receiving organ transplants (Bok et al. 2006). Although there is still disagreement as to the causative agent of the symptoms accompanying aspergillosis, many scientists suspect that the compound, gliotoxin, plays a …
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Interactions between the haematopoietic stem cell and the myeloid microenvironment in aplastic anaemia
In patients with aplastic anaemia that respond to immunosuppressive therapy, quantitative, morphological and functional haematologic derangement have been reported. To explain these findings, abnormalities in the marrow stroma or the stem cell have been postulated. To define the relative …
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Force-extension of the Amylose Polysaccharide
… MG patients of African genetic ancestry develop immunosuppressive therapy-resistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury. Sequence analysis of relevant regions of …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… rejection and to eliminate the need for systemic immunosuppressive therapy. Cell encapsulation is an attractive technology to enable donor cell transplantation, but clinical success has remained elusive due to immunological responses to the encapsulated materials. Alginate is the leading material …
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Lymphocytopenia in patients with inflammatory bowel disease on immunosuppressive medications
… and 6-mercaptopurine (AZA/6MP) are effective immunosuppressives commonly used for the treatment of inflammatory bowel disease (IBD). The mercaptopurine metabolites, 6-thioguanine (6TG) and 6-methylmercaptopurine ribonucleotides (6MMP), have been suggested as surrogate markers of the safety and …
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Clinico-pathological correlation and outcome in patients with mesangioproliferative glomerulonephritis in Cape Town: A single centre study
… Whether this is related to the limited use of immunosuppressive therapy in IgAN patients or represents a true nature of the disease still requires further research.
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The incidence of tuberculosis in the inflammatory bowel disease registry in Cape Town, South Africa
… inflammatory bowel disease (IBD) patients using immunosuppressive therapy (IST) is higher than the background population in developed countries. Corresponding data in areas of high endemicity like South Africa (SA) is limited. Our objectives were to calculate the incidence, identify predictors …
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CRITICALLY ILL PATIENTS WITH COVID-19 PNEUMONIA: PATHOPHYSIOLOGY, IMPACT OF VACCINE, AND CLINICAL OUTCOME.
… fewer comorbidities and a lower prevalence of immunosuppressive therapy, ICU mortality was not associated with vaccinated status.
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MUTATION OF REGNASE-1 CAUSES PRIMARY IMMUNODEFICIENCY ASSOCIATED WITH AUTO-INFLAMMATORY DISEASE
… IL-6. Throughout his life the patient received immunosuppressive therapy. Whole exome sequencing of the patient discovered a homozygous frameshift mutation in the ZC3H12A gene that encodes the Regnase-1 protein also known as MCPIP1. Regnase-1 is a regulatory RNase that directly degrades mRNAs of …
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In Vitro Models of Cellular Dedifferentiation for Regenerative Medicine
… own tissues allows for transplantation without immunosuppressive therapy as well as patient-specific disease modeling and drug testing. The objective of this study was to use cellular dedifferentiation to create in vitro cell lines with which to study regenerative medicine. First, we used siRNA …
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Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… injury are 1.) the presence of immunosuppressive molecules within the aqueous humor; 2.) the expression of pro-apoptotic factors on corneal cells ; and 3.) the induction of a form of immune tolerance called anterior chamber-associated immune deviation (ACAID). Immune privilege …
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Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency
… life-long glucocorticoid (GC) replacement therapy. GC doses used for replacement therapy in these diseases are much lower than GC doses used for immunosuppressive therapy. However, current daily GC doses are still higher than the reported adrenal cortisol production rate. This GC excess …
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A study of a multi-systemic immune-mediated disease in the English Cocker Spaniel
… studies are required to assess the efficacy of immunosuppressive therapy, and identify the pathogenesis and genetic basis of the disease. This will contribute to improve diagnosis and treatment resulting in the improvement of the quality of life in affected dogs.
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Investigating the functionality of candidate susceptibility genes in ophthalmoplegic myasthenia gravis using patient-derived material
… weakness which does not respond to standard immunosuppressive therapy whilst the non-ocular muscles do respond to treatment. OP-MG predominantly affects patients of African genetic ancestry and most commonly those with juvenile-onset. The cause of OP-MG is unknown. Previously, in efforts to …
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