Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Immunosuppressive agents."”.
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In vitro studies of the effects of funfal-derived immunosuppressive agents on MCF7 breast cancer cells and Molt4 Leukaemia cells
… therapeutic and aide effects of fungal-derived immunosuppressive drug such as Cyclosporin A (CsA) are still controversial, with the same amount of data published to date that states the beneficial effects of immunosupressants as well as their side effects. The molecular mechanism by which CsA on …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… in hyperacute rejection. The development of immunosuppressive agents such as Cyc1osporine A and Tacrolimus have significantly improved the survival of organ transplants. However, although there is a good 1-5 year survival, the recurrent problem of chronic rejection still remains, and …
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Strategies to Employ Androstenediol to Reverse Steroid Inhibited Healing in a Rat Model of Trauma
… strategies to evaluate which levels of trauma, immunosuppressive agents, and Androstenediol are required to reverse inhibition of healing. Sprague-Dawley rats were assessed for their response to trauma and intervention through assessment of white blood cell levels, cytokine and chemokine …
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Eliminating oxygen supply limitations for transplanted microencapsulated islets in the treatment of type 1 diabetes
… requires permanent use of multiple immunosuppressive agents. These agents may have serious side effects as well as a substantial financial burden. Microencapsulation is used for full or partial protection of transplanted islets from immune rejection. However, the microcapsule …
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Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis
… possible use as cancer chemotherapics and as immunosuppressive agents, but no clinical trial has been so far approved for the evaluation of their efficacy in the context of immunological disorders. Methods In the current study, we have firstly evaluated in silico the involvement of the mTOR …
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The immunogenicity of embryonic stem cell-derived midbrain dopaminergic progenitors and its implications as a therapy to treat patients with Parkinson’s Disease
… in vitro. Finally, I looked at the effects of immunosuppressive drugs on mDAps survival and maturation in vitro given these agents will be given in the early phase clinical trials using these cells. I found that most of such agents did not affect the survival or maturation of the DA neurons, …
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The Effect of Rapamycin Paired with Traumatic Memory Activation on Cognitive Performance in Veterans Diagnosed with PTSD
BACKGROUND: Many individuals with posttraumatic stress disorder (PTSD) experience cognitive impairment in addition to the characteristic psychological symptoms. Animal studies have shown that rapamycin, a protein synthesis inhibitor that targets the protein kinase mTOR, can prevent the …
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Improving the skin barrier function in atopic dermatitis
… an alternative to current anti-inflammatory and immunosuppressive agents used to treat AD.
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Analysis of the Metabolism of Dextran-Methylprednisolone Succinate Using
A brief review of past and present immunosuppressive treatments, including corticosteroids,cyclosporine A, and tacrolimus as they relate to liver transplantation is presented. The most common and detrimental side effects are presented for each therapy, and a method to reduce these adverse effects …
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Structural and electrostatic analysis of HLA B cell epitopes: Inferences on immunogenicity and prediction of humoral alloresponses
Despite the use of potent immunosuppressive agents, injury secondary to the alloimmune response principally directed against mismatched HLA antigens, remains a significant cause of renal transplant dysfunction and loss. One of the principal ways to limit the detrimental effect of immune …
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Regulation of Autoimmune Germinal Center Reaction By Tfh Cells and Application of Tfr-Like Cells For The Treatment of Autoimmune B Cell Responses
… autoimmune diseases. Although different types of immunosuppressive agents have been used clinically to treat antibody-mediated autoimmune diseases, they generally have side effects due to the lack of target-specificity. To minimalize the adverse effects, there is a need to develop target-specific …
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Culturally Informed Motivational Interviewing to Improve Oral Chemotherapy Adherence for Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers: A Feasibility, Acceptability, and Preliminary Efficacy Trial
BACKGROUND: Curative therapy for childhood acute lymphoblastic leukemia (ALL) mandates a two-to-three-year maintenance chemotherapy phase wherein patients must take daily oral 6-mercaptopurine (6-MP). 6-MP regimen adherence is challenging and failure to take medication has been associated with an …
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Studies of immunoglobulin receptors and human proximal tubular cells
… then studied the effect of calcineurin inhibitor immunosuppressive drugs as a model of tubular toxicity, and statins as immunomodulatory drugs, reputed to protect renal function and known to have immunomodulatory effects. I hypothesised that immunosuppressant agents/statins either alone or in …