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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 337 for “"Immunosuppressive"”.
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… besides current known immune checkpoints, other immunosuppressive components in the tumor microenvironment (TME) need to be targeted to elicit the full immune responses.</p> <p>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive myeloid cells that are involved …
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
… by secreting growth factors as well as immunosuppressive, pro-angiogenic and/or pro-metastatic mediators. In this thesis we identified a factor (Wnt5a) that may be involved in skewing immune responses towards immunosuppressive, tumor promoting immune cell populations. In a …
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Changes in peripheral B cell subsets under immunosuppressive therapy
… with special emphasis on changes induced by immunosuppressive therapy (disease modifying antirheumatic drugs (DMARDs)) and cyclophosphamide (CYC) treatment. There was a significant impact of immunosuppressive treatment on peripheral B cell subsets in SLE and WG patients. Absolute lymphocyte …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… tumor immunity and find VEGF induces an immunosuppressive phenotype in VEGFR2+ myeloid cells including directly upregulating the expression of programmed cell death 1-ligand 1 (PD-L1). Moreover, I demonstrate that VEGF blockade inhibits the immunosuppressive phenotype of VEGFR2+ myeloid …
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Lymphocytopenia in patients with inflammatory bowel disease on immunosuppressive medications
… and 6-mercaptopurine (AZA/6MP) are effective immunosuppressives commonly used for the treatment of inflammatory bowel disease (IBD). The mercaptopurine metabolites, 6-thioguanine (6TG) and 6-methylmercaptopurine ribonucleotides (6MMP), have been suggested as surrogate markers of the safety and …
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Investigating the immunosuppressive functions of the GPCR adapter protein Norbin
This project investigated the roles of Norbin, an adaptor protein which regulates trafficking and signalling of G protein-coupled receptors (GPCRs). Norbin was originally expected to be exclusively neuronal. However, previous PhD students in our laboratory found that Norbin is also expressed in …
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The association of tumor-induced changes in macrophage phenotype with immunosuppressive functions
During tumor growth there are a series of phenotypic and functional changes that occur in macrophages (M<sub>Φ</sub>) that ultimately lead to the immunosuppression of the tumor-bearing host (TBH). To investigate the phenotypic changes of M<sub>Φ</sub> during tumor growth, we examined the expression …
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Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation
… allogeneic bone marrow transplantation (BMT) or immunosuppressive treatment in severe aplastic anemia (SAA) and identified prognostic factors related with survival. METHODS: Medical data of SAA patients who treated with BMT or immunosuppressive therapy (IST) at the Ajou University Hospital from …
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Suppression of T-Helper Cell Function by a Soluble Immunosuppressive Factor From Plasmodium Berghei Infected Rat Erythrocytes
… but not control erythrocytes, exhibited immunosuppressive properties when tested in vivo. Mice treated with the immunosuppressive factor (ISF) and then immunized with sheep red blood cells (SRBC) had a reduced number of plaque forming cells (PFC) as compared to mice injected with control …
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Development of a rapid diagnostic screen for telomerase mutations associated with immunosuppressive therapy failure in patients with aplastic anaemia
Includes abstract. Includes bibliographical references.
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In vitro studies of the effects of funfal-derived immunosuppressive agents on MCF7 breast cancer cells and Molt4 Leukaemia cells
… therapeutic and aide effects of fungal-derived immunosuppressive drug such as Cyclosporin A (CsA) are still controversial, with the same amount of data published to date that states the beneficial effects of immunosupressants as well as their side effects. The molecular mechanism by which CsA on …
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Isolation, Characterization and Studies of the Mode of Action of a Non-Specific Immunosuppressive Peptide Derived From Normal Bovine Serum
Made available in DSpace on 2014-12-11T21:33:45Z (GMT). No. of bitstreams: 1 7309965.pdf: 2676011 bytes, checksum: 700a72f05d6778e72f2c84f01253db4a (MD5) Previous issue date: 1972
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The Mode of Action of Immunoregulatory Alpha Globulin (IRA) on Murine Lymphocytes: Relation of the Immunosuppressive Activity of Various Pathologic Conditions
… in the literature indicate that there are immunosuppressive components in the alpha globulin fractions of human and murine sera (1, 2, 3, 4, 5, 6, 7, 8, 9). These investigations shed new insights on the mechanisms controlling immune responses in normal individuals, and may elucidate the …
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Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma
… Immunotherapy commonly fails due to the immunosuppressive tumor microenvironment (TME). The aim of my dissertation is to develop strategies that dampen the TME’s immunosuppressive capacity and improve the antitumor performance of vaccine-induced melanoma-associated antigen (MAA)-specific …
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Therapeutic Strategies to Target LILRB Receptors on Myeloid Cells for Cancer Immunotherapy
… treating some but not all patients with cancer. Immunosuppressive myeloid cells which inhibit anti-tumor immunity are recognized as one of the major obstacles in cancer treatment. LILRB3 and LILRB4, immune inhibitory receptors containing tyrosine-based inhibitory motifs (ITIMs), are expressed …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… in hyperacute rejection. The development of immunosuppressive agents such as Cyc1osporine A and Tacrolimus have significantly improved the survival of organ transplants. However, although there is a good 1-5 year survival, the recurrent problem of chronic rejection still remains, and …
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