Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Immunosuppressant"”.
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The susceptibility of baboons to the novel immunosuppressant, FTY720
Since there is a major scarcity of donor organs world-wide, the experimental search for human organs has focused on two alternatives; mechanical devices and cross-species transplants. The use of mechanical devices as substitute organs is understandably limited due to complications from trying to …
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Quantitative Modeling and Optimal Control of Immunosuppressant Treatment Dynamics in Renal Transplant Recipients.
North Carolina State University Theses Biomathematics.
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Immunotherapy for murine glioma
… activating tumor-specific T cells and an anti-immunosuppressant would improve treatment of gliomas. An oncolytic virus encoding IL15Ra-IL15 (the T cell activating stimulus) and the prostaglandin synthesis inhibitor celecoxib (the anti-immunosuppressant) were combined with adoptive transfer of …
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NOVEL SYNTHETIC PROCESSES FOR THE INDUSTRIAL PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS
… A. This new derivate has been approved for the immunosuppressant medication treatment of Lupus nephritis. A four synthetic steps process was developed to afford the product with the required purity and isomeric composition.
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Current Strategies and New Avenues in the Management of Non-Infectious Ocular Inflammation
… are based on the use of corticosteroid and immunosuppressant. However, not all patients respond well to conventional therapy, consequently they are offered biological response modifiers. They are fundamentally more effective, but it is not typically recommended at first, given its high cost …
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MPhil in pulmonary haemorrhage in children in Cape Town
… The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated …
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Investigating immunosuppression as a disease modifying strategy in Parkinson's disease
… conditions and reduced by the use of immunosuppressant and anti-inflammatory drugs. The immune also system shows an abnormal profile in PD patients. Microglia, the immune cells of the brain, are activated in PD. Abnormalities are also present in the peripheral immune system, with …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… are treated with prednisone as the first-line immunosuppressant and frequently, an additional steroid-sparing agent, such as azathioprine, cyclosporin A or methotrexate. We hypothesised that MG patients with the C>G SNP when treated with immunosuppressant drugs, may have lower DAF protein …
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Studies towards the total synthesis of Antascomicin A.
… properties of the structurally related immunosuppressant natural products rapamycin and FK-506 are also discussed. The. second section reviews methods to date of synthesising the masked tricarbonyl unit which is present in antascomicin A, rapamycin, and FK-506. This includes both …
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Studies of immunoglobulin receptors and human proximal tubular cells
… immunomodulatory effects. I hypothesised that immunosuppressant agents/statins either alone or in combination with LPS might affect Ig receptors expression, cytokine release, FN production and proliferation by PTEC. My results inferred that immunosuppressive agents alone have a non-inflammatory …
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A novel photocatalytic strategy for complex aliphatic amine synthesis and the total synthesis of alkaloids (−) FR901483 and (+)-TAN1251C
… in a number of bioactive natural products. Immunosuppressant ($-$)-FR901483 (1) and muscarinic antagonist ($+$)-TAN1251C (2) are biosynthetically related di-tyrosine-derived alkaloids, which have attracted significant attention from the synthetic community by virtue of their biological …
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The effects of topical calcipotriol treatment on immune responses to vaccination
… and compare it with another common topical immunosuppressant, the corticosteroid betamethasone-17-valerate (BMV). Functionally, calcipotriol and BMV treatment both result in the suppression of CD8⁺ T cell priming in response to subcutaneous vaccination, despite the topical co-administration …
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Improving the dietary management of orofacial granulomatosis
… an allergic component. Management includes immunosuppressant medications or a cinnamon and benzoate free diet which has proven benefit in 72% of patients. The diet is challenging, not all patients respond and symptom recurrence is common. Patients identify chocolate as a problem but are …
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Drug design strategies for modulating immune activity for the treatment of autoimmune diseases and cancer
… may be a safer treatment option than traditional immunosuppressant therapies that suppress many parts of the immune system. In chapter 4, we used a cationic polypeptide, glatiramer acetate (Copaxone®), as a vehicle to help deliver CpG, a negatively-charged immunostimulant. We previously …
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Characterizing Effects of Sphingosine-1-Phosphate Receptor 1 Activation in Subtypes of Central Amygdala Neurons and Effects of Prenatal Methadone Exposure on Motor Cortex Neurons in Mice
… ligands have been utilized as an effective immunosuppressant, treatment in multiple sclerosis and studied as a treatment for pain. The primary cellular response to S1P is thought to be elicited through S1PR type 1 (S1PR1). My first goal was to understand how S1PR1 signaling affects neuronal …
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Part I: Disruption of PTEN-5-HT2CR Coupling: A Potential Treatment for Restoration of 5-HT2CR Function / Part II: Rapid Total Synthesis of Cyclodepsipeptide MA026
… antiviral, antibacterial, anthelmintic, immunosuppressant, anti-inflammatory, and antimalarial activities. A novel cyclodepsipeptide, MA026, which has been shown to have antiviral activity, was discovered in 2002. The first total synthesis of MA026 was accomplished in solution-phase …
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The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
… by the drug rapamycin which is a powerful immunosuppressant used in the clinic in the context of organ transplantation. However, not much is known about the full extent of the role of mTOR signalling in CTL.<br/>We thus utilised high resolution quantitative mass spectrometry to define the …
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