Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Immunostimulation"”.
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Development of polymeric nanoparticle vaccines for immunostimulation
Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant gains in the understanding of the underlying mechanisms involved in developing …
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Assessing Helicobacter pylori's HcpE and DsbK's Effects on Immunostimulation in Host Gastric Cells
Helicobacter pylori (HP) colonizes half the world population. It causes chronic gastric inflammation that often leads to ulcers and cancers. Considering rising antibiotic resistance and patient noncompliance, the search for an alternative treatment is essential. HcpE, a member of the Helicobacter …
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The Effect of Leucogenenol on Classical Chemotherapy and Immunotherapy of Friend Virus Disease
… the untreated controls at the time of death. Immunostimulation with leucogenenol, BCG, or both had no appreciable effect on any of the parameters of the disease. Conclusion. It was concluded that the effect of MTX therapy was to suppress the production and sensitization of T-lymphocytes so …
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The Development and Application of a Hemolytic Plaque Forming Cell Assay (PFC) and a Cytotoxic T-Lymphocyte Assay (CTL) in Tilapia (Oreochromis niloticus) for Immunotoxicity Risk Assessment of Environmental Contaminants
… Under specific immunization circumstances, immunostimulation (also a response to immunotoxicity) was noted via an increase in plaque number in benzo[a]pyrene (B[a]P) exposed fish using the PFC assay, a result noted in rodents as well. Reduced T-cell recognition and lysis of allogeneic …
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Bacterial Kidney Disease and Its effect on the Salmonid Immune response
… ramifications for control measures involving immunostimulation via antigen exposure. Further investigation is warranted to discern the significance and consistency of immunological hypersensivity in BKD pathogenesis. Chapter 4 examines the renal lesions, including immunopathologic changes and …
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Approaches towards therapeutic development against chronic brucellosis in a mouse model
… two approaches, intracellular drug delivery and immunostimulation, have been explored in this dissertation, with an aim to develop a better therapeutic against Brucella infection in mice. First, to overcome the cell membrane barriers, drug loaded nanoparticles were tested to treat B. melitensis …
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Streptavidin-cytokine fusion proteins for use as adjuvants in cancer vaccines
… weak and it has been reported that additional immunostimulation, such as that provided by an immunoadjuvant, is required in order to achieve effective therapeutic results. One approach to the development of novel immunoadjuvants is the production of fusion proteins which are designed to perform …
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The in vitro effects of heavy metals and nanoparticles on the immune system
… could potentially result in immunosuppression or immunostimulation in individuals exposed to these compounds.
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Utilizing the Immunomodulatory Effects of Electroporation for Treating Brain Tumors
Brain tumors are among the most devastating types of solid tumors to treat. Standard of care for glioblastoma (GBMs), the most aggressive form of primary brain tumors, has failed to improve the current survival rates in the past decades. Despite many other solid tumors, recent advances in cancer …