Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Immunostimulants"”.
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Approaches towards therapeutic development against chronic brucellosis in a mouse model
… outer membrane vesicles (OMVs), were tested as immunostimulants to treat chronic B. melitensis infection in mice in combination with antibiotics. The non-ionic block co-polymer Pluronic P85, when mixed with OMVs as an adjuvant showed significantly higher protection against B. melitensis …
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Synthesis of Saponin Immunoadjuvants
… developed, facilitating the discovery of novel immunostimulants with increased potency, stability and attenuated toxicity. This method was applied to the synthesis of the natural product adjuvant QS-7-Api and to non-natural aza-saponins. In this initial foray into designed molecular adjuvants, …
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Characterization of an IL-12-driven Anticancer Response, and the CD4+ CTL Population Incited, in a Murine Model of Leukaemia
… an important consideration when studying other immunostimulants. I have herein developed a novel in vitro assay system that I have used to dissect the cellular responses to IL-12 and to identify the signals that are required for activation of a cluster of differentiation 4 (CD4)+ effector …
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Πορείες συνθέσεως ενώσεων με βιολογικό ενδιαφέρον από 2Η-πυραν-3(6Η)-όνες
… (Michael) to 2H-pyran-3(6H)-ones. c) Immunostimulants. d) Sympathomimetic amines, neurotransmitters. Part II contains five chapters and deals with the results of the present work. More specifically describes: i) The synthesis of 2H-pyran-3(6K)-ones derivatives which were used as …
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Immune and Endocrine Modulations Associated with Enhanced Plant-Based Protein Diets Within Freshwater Fish Species
… induced by the BSBM ingredients or dietary immunostimulants in yellow perch (<em>Perca flavescens</em>) and rainbow trout (<em>Oncorhynchus mykiss</em>), two domestically cultured species. Nonspecific immune components were characterized by trials incorporating graded inclusion levels of …
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CHARACTERIZATION AND PATHOLOGICAL STUDY OF A. HYDROPHILA IN WALKING CATFISH (CLARIAS GARIEPINUS)
… A. hydrophila via immunization or treated with immunostimulants.
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Nutritional control of gene expression, larval development and physiology in fish
… specifically centering attention on immunostimulants for which the underlying mechanisms of action remain poorly characterized. Here, dietary MOS, nucleotides and selenomethionine (Se-met) were offered to zebrafish whose transcriptome was analyzed by microarray. The immune system, …
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Animal models for investigating coronavirus heterotypic immunity
… memory lymphocytes, and this can be boosted by immunostimulants. In the Balb/c inbred mouse line, the T cells and antibodies generated do not cross-react with SARS-CoV-2 structural proteins and experienced mice are not protected from SARS-CoV-2. In contrast, naïve macaques have greater markers …
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Investigating alternative delivery systems for self-Amplifying RNA vaccines
… or dimethyldioctadecylammonium (DDA) - known as immunostimulants.;In the preliminary studies, two different manufacturing processes such as Microfluidics and Microfluidisation were applied. As a proof of concept, anionic liposomes and solid lipid nanoparticles were formulated and ovalbumin was …
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Immunostimulatory effects of different aspects of aquaculture on the host response in the edible sea urchin, paracentrotus lividus
Aquaculture is a fast-growing industry contributing to global food security and sustainable aquaculture, which may reduce pressures on capture fisheries. The overall objective of this thesis was to look at the immunostimulatory effects of different aspects of aquaculture on the host response of the …