Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Immunosenescence"”.
-
Markers of immunosenescence and oxidative stress in healthy adults
… investigated markers of oxidative stress and immunosenescence in healthy adults. The results presented represent several novel findings which support the notion that oxidative stress and infection with micro-organisms shape our biology and can accelerate aspects of ageing. Acute exercise of …
-
The role of immunosenescence in autoimmune/autoinflammatory pathogenesis of Behçet's disease
… such as blindness and large vessel inflammation. Immunosenescence, aging of immune system, is related to increased susceptibility to infectious diseases, vaccine failure, and chronic low grade systemic inflammation. The role of immunosenescence in BD is not well understood. Therefore, the aim of …
-
Abnormal regulation of T lymphocytes from aged rats contributes to immunosenescence
Regulation of T lymphocyte proliferation from aged rats was explored by activating lymphocytes to proliferate with the T cell lectin Con A, the calcium ionophores A23187 and ionomycin and the protein kinase C activator, PMA. Similar to human T lymphocytes, but unlike mouse lymphocytes, rat …
-
Immunosenescence in B Cells: A Study on Changes in Immunoregulator Expression and Metabolism With Age
… to influenza viruses. To address this, I studied immunosenescence in B cells and antibody secreting cells (ASCs) in mice and humans. In humans, I measured humoral immune responses to the trivalent inactivated influenza vaccine (TIV) during the 2011-12 and 2012-13 influenza seasons. ASCs in the …
-
Antioxidents or reduced oxygen tension as a defense system in T cells ex vivo and in vitro
… and dysregulation of T cell function, termed ‘immunosenescence’, may lead to increased mortality and morbidity in humans through greater susceptibility to infections and disease. Previous research from the group of Barnett, suggested that oxidative stress may play a role in the immunosenescence …
-
Sarcopenia and cognitive ageing: investigating their interrelationship, biological correlates and the role of glucocorticoids
… speed. I found an association between markers of immunosenescence and sarcopenia (neck muscle CSA and grip strength) and an association between expression of the cortisol amplifying enzyme 11βHSD1 and quadriceps strength. I developed a technique to measure 11βHSD1 activity across the human brain, …
-
Age-Dependent Variability in Immune Host Responses to SARS-CoV-2: Implications for Inclusive Clinical Trial Design
… by age-associated immune dysfunction, or immunosenescence. This dissertation investigates the immune responses that contribute to protection against SARS-CoV-2 and how these responses become dysregulated with increasing age. Given the evidence of impaired antiviral immunity in aged models, …
-
SARS-CoV-2 Variants and Vaccines
… determined to be a vulnerable population due to immunosenescence, which resulted in lower spike-specific antibody binding titres, lower neutralising antibody titres against spike pseudotyped viruses, lower T cell interferon gamma (IFNγ) and interleukin-2 (IL-2) responses, and reduced …
-
Investigating immunosuppression as a disease modifying strategy in Parkinson's disease
… impaired regulatory function and a lack of immunosenescence normally seen with aging. T lymphocytes infiltrate the brain in PD, where they are found in higher numbers than in controls. Inflammatory cytokine levels are also elevated in the cerebrospinal fluid in PD[1], and a pro-inflammatory …
-
Age-dependent changes in the mouse lymph node and implications for immune responses
Older individuals tend to have an impaired production of antibodies after vaccination, however the cellular and molecular changes that cause this have not fully been elucidated. In this PhD project I aimed to investigate different aspects of the lymph node microenvironment to determine whether …
-
Aging and Sympathetic Neurotransmission in Two Strains of Rats that Differ in Longevity and Immune Profiles
… in immune organs may be associated with immunosenescence; however no causal relationship has been established. From previous studies in Fischer rats (F344), we have found that during middle age, sympathetic nerve activity (SNA) rises in the spleen followed by a decline in noradrenergic …
-
Zinco, invecchiamento e sistema immunitario: effetti sull'apoptosi e sulla proliferazione dei linfociti
Immunosenescence is characterized by a complex remodelling of the immune system, mainly driven by lifelong antigenic burden. Cells of the immune system are constantly exposed to a variety of stressors capable of inducing apoptosis, including antigens and reactive oxygen species continuously …
-
Effects of exercise on age- and stress- related attenuation of vaccination responses in mice
… Normal aging and chronic stress can lead to immunosenescence and immunosuppression, respectively, and there may be a role for exercise in augmenting immune responses under these conditions. However, the underlying mechanisms as to how such exercise might promote this effect is unclear. In …
-
Evaluation of the Aging Immune System Using a Mouse Model of Brucella Infection
Aging is accompanied by dysregulated immune function resulting in increased susceptibility of the elderly to diseases caused by microbial pathogens. There exists a multitude of data suggesting decreased resistance of the elderly to a variety of intracellular pathogens but there is no data relating …
-
Telomerlängendynamik in Subpopulationen peripherer Blutlymphozyten in vivo und in vitro
Im Rahmen dieser Arbeit wurde die Telomerdynamik von peripheren B- und T-Lymphozyten unter zwei verschiedenen Gesichtspunkten untersucht: <br> <br>Im ersten Abschnitt wurde die in vivo Telomerdynamik von B- und T-Zellen im Verlauf des menschlichen Lebens analysiert: Hierzu wurden die Telomerlängen …