Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Immunoregulation"”.
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Cellular and Molecular Mechanisms of Immunoregulation In Vivo
… host. Redundant and non-redundant mechanisms of immunoregulation exist that establish the balance between inflammatory responses to maintain homeostasis. Also, these immunoregulatory mechanisms act at different layers of the immune response to maintain homeostasis including: epithelial barriers, …
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Positive and negative immunoregulation of normal and tumor-bearing mouse T cell blastogenesis
… was made of positive and negative blastogenic immunoregulation by syngeneic peritoneal macrophages (M<sub>Φ</sub>) and splenic T cells from tumor-bearing mice (TBM). As analysis of T cell proliferative response progressed an intricate pattern of immunoregulatory checks and balances unfolded …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) which is thought to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in …
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The use of organic ligands to study the molecular mechanisms of angiogenesis and immunoregulation
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1999.
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Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
Facial nerve axotomy (FNA) in immunodeficient mice causes significantly more facial motoneuron (FMN) loss relative to wild type (WT), indicating that the immune system is neuroprotective. Further studies reveal that both CD4+ T cells and interleukin 10 (IL-10) act centrally to promote neuronal …
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Genetic Control of Experimentally Induced Reproductive Autoimmune Phenotypes
… between genes in reproductive autoimmunity and immunoregulation.
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Investigating genetic and molecular factors contributing to sexual dimorphism in lung disease
… disease diagnosis. Therefore, sex differences in immunoregulation are observable ex vivo, where biological factors such as sex hormones are removed. Thus, intrinsic molecular and genetic factors such as the sex chromosomes likely contribute to this difference. Highly similar but non-exact gene …
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Studies of the idiotypic network through the use of a novel hemolytic plaque assay
… responses to the same antigens, suggesting that immunoregulation may occur within these idiotypic networks. Inhibition studies of these same Ab2 producing cell populations suggest that an increase in average affinity may occur between the primary and secondary responses to DNP-Ficoll in the …
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Age-associated alterations in the immune system of normal and autoimmune-susceptible mice
… increasing age, the autoreactive T cell-induced immunoregulation is disturbed, which may account for reduced immune responsiveness to foreign antigens and increased susceptibility to autoimmune diseases.
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Immunological Characterization of Human Umbilical Cord Lining Derived Cells and their Therapeutic Application in a Diabetic Mouse Model
… important role for soluble HLA-G. However, this immunoregulation by CLECs did not involve induction of T cell apoptosis or expansion of regulatory T cells. In in vivo studies in immunocompetent mice, transplanted CLECs could be maintained for extended periods while acute xeno-rejection rapidly …
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Characterising the immunometabolic profile of HIV/TB co-infection
… or immunoregulatory, suggests a failure of immunoregulation, resulting in an increased disease burden. Metabolites indicative of cachexia, damage of the intestinal mucosa and dysbiosis of the microbiome characterised co-infected individuals from the TB-positive population, while co-infected …
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The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
… tissue integrity during infection, and immunoregulation remains elusive. This dissertation interrogates the paradoxical role of SDC1 in HSV-1 infection and demonstrates that, beyond serving as a viral attachment factor, SDC1 functions as a critical regulator of inflammation and tissue …
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Regulation and Effector Function of TH1 and TH2 Cells in Immunity to Bordetella Pertussis
… IL-4 was demonstrated in the parasite-induced immunoregulation.
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The association of tumor-induced changes in macrophage phenotype with immunosuppressive functions
… In conclusion, tumor growth leads to a change in immunoregulation that causes suppression of the immune response.
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Phenotypic and functional changes in populations of murine macrophages during tumor growth
… data suggest that tumor-induced aberrations in immunoregulation can be attributed to differences in Mφ subpopulations which were discriminated by their surface membrane components.
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Small molecule inhibition of immunoregulatory protein-protein interactions
Selective molecular recognition between proteins is a fundamental event in biological processes that governs cellular growth, function, survival, and differentiation. The immune system, for example, is a complex network of cellular processes regulated by protein-protein interactions (PPIs) between …
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