Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Immunoreceptor tyrosine-based activation motif"”.
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
FcyRIIa is an activatory receptor and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, involved in the initiation of signalling events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate …
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The Role of the ITAM-containing CEACAM3 Receptor in the Neutrophil Response to Infection by Neisseria gonorrhoeae
… are often characterized by a massive influx and activation of neutrophils, white blood cells involved in the early/innate immune response to pathogens, at the infection site. Neisseria spp. bind to and activate neutrophils via their Opacity-associated (Opa) outer membrane proteins, which interact …
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Characterization of a Novel Signaling Motif in the CD3 ε Subunit of the T Cell Receptor
… contains one or more copies of a signaling motif termed an immunoreceptor tyrosine-based activation motif (ITAM). Phosphorylation of tyrosine residues within the ITAMs is critical for TCR-mediated signaling events. We identified an additional signaling motif in the cytoplasmic tail of CD3 ε …
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Biophysical studies of the allosteric regulatory mechanism of Syk tandem SH2 domains interacting with immunoreceptor tyrosine-based activation motifs
<p>The non-receptor spleen tyrosine kinase (Syk) is an important player in signal transduction from immunoreceptors to various downstream targets. It is widely expressed in both haematopoietic and epithelial cells. Syk disorder is closely related with many inflammatory and autoimmune diseases, as …
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Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice
… Further studies showed that platelet activation by CRP, or thrombin induced down-regulation of GPIb, but not GPVI. In parallel, cellular regulation of GPV was studied and it was found that GPV is cleaved in vitro by the metalloproteinase ADAM17. In previous studies it was shown that …