Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Immunoprophylaxis and Therapy"”.
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Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines
… antigen alone. We move unto an in vivo model and note significant increases in the expansion of antigen specific class I T cells but not class II T cells when receiving mBD2 vaccine over antigen alone. Further, knowing mBD2’s link with CC chemokine receptor 6 (CCR6) and Toll-like receptor 4 …
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Use of Cholera Toxin B as a Vaccine Adjuvant Activates Antigen Presenting Cells and Stimulates Production of Pro-Inflammatory Cytokines
… strain (<em>FT LVS</em>) of the bacterium and provided partial protection against a more virulent strain (SchuS4). However, the mechanisms of this protection are not fully understood. In this present study, an <em>in vitro</em> system was utilized to further elucidate the mechanisms that …
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Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
… derived suppressor cells (MDSCs) in the spleen and lymph nodes of immunized mice. For the first time, we demonstrated that by eliminating G-CSF in ATCVs, the overall efficacy of the vaccine can be significantly improved. Further, for the first time, by using breast cancer cells that naturally …
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Investigating The Roles of Lung Epithelial Stat3 In Therapeutically Inducible Resistance to Acute Bacterial Pneumonia.
… dynamic tissue capable of displaying structural and functional plasticity in response to pathogenic challenges. Our lab has demonstrated that it is possible to therapeutically exploit the lung epithelium’s versatility by inducing resistance to lethal pneumonias caused by viruses, bacteria and …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
… Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a subset of patients with advanced melanoma, …
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Utilization of Cholera Toxin B as an Adjuvant for the Subunit PspA Vaccine, Provides Effective Protection against Streptococcus pneumoniae Challenge
… die each year, specifically with young children and the elderly comprising a significant portion. Currently, antibiotics can treat the infection but individuals such as the young or elderly are more susceptible to bodily damage from symptoms, such as pneumonia, meningitis, and sepsis, thus …
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Natural and Exogenous Genome Editing In Wiskott-Aldrich Syndrome Patient Cells
… by thrombocytopenia, recurrent infections and increased autoimmunity. This disease is caused by mutations in the WAS gene (<em>WAS</em>) which encodes for the WAS protein (WASp), exclusively expressed in hematopoietic cells and required for proper platelet production and lymphoid cell …
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Immunological Mechanisms of Extracorporeal Photopheresis In Cutaneous T Cell Lymphoma and Graft Versus Host Disease
… PHOTOPHERESIS IN CUTANEOUS T CELL LYMPHOMA AND GRAFT VERSUS HOST DISEASE</strong></p> <p>Publication No.___________</p> <p>Lisa Harn-Ging Shiue, B.S.</p> <p>Supervisory Professor: Madeleine Duvic, M.D.</p> <p>Extracorporeal photopheresis (ECP) is an effective, low-risk immunomodulating …
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Tumor Immunotherapy: Mechanisms of Acquired Resistance and Characterization of Immune Related to xicities
<p>Tumor immunotherapy has shown very promising clinical benefit across an array of cancers; however, two major challenges remain unresolved in the field. First, many patients do not respond to therapy at all or relapse after a period of remission. Second, there are often dose-limiting immune …