Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 75 for “"Immunopathology"”.
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Investigations into the immunopathology of inflammatory arthritis
This volume contains an introduction to the topic of inflammatory arthritis, followed by Chapter 2 which is a Materials and Methods section and includes experimental protocols used for the original research detailed in Chapters 3 to 6 (Sections 2.1 - 2.4). Chapters 3 to 6 are each followed by their …
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
… role of APC in virus infection, persistence and immunopathology using the LCMV model. The LCMV model is a well-established model system for studying the immune system and its interaction with pathogen. It has contributed to some fundamental discoveries in the field of immunology and virology; for …
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
Although the phenomenon of synergistic cell death induced by the combination of IFN-γ and TNF-α has been known for more than 30 years, the underlying mechanisms are still not clear. The main aim of my PhD was to identify the mechanisms which are required for the killing of human intestinal …
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Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection
… gondii triggers severe small intestinal immunopathology that recapitulates many characteristics of IBD such as elevated IFN-g and microbiota-mediated inflammation, along with disappearance of Paneth cells. However, little is known about what happens to these Paneth cells and if their loss …
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Diagnosis, treatment and immunopathogenesis of the HIV-associated tuberculosis immune reconstitution inflammatory syndrome
… or recurrent inflammatory features of TB due to immunopathology attendant on rapidly recovering immune function.
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The role of BATF2 during of experimental murine Schistosomiasis
… eggs, even after treatment. Intestinal and liver immunopathology are pathognomonic of schistosomiasis and generally result from the host inadequate Th2 and or Th17 responses to the egg-derived antigens. Failure to control these immune responses causes the most of the detriment to the infected …
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THE INNATE CYTOKINE IL-18 INHIBITS CNS AUTOIMMUNITY THROUGH PREFERENTIAL ACTIVATION OF PROTECTIVE CD8 T-CELLS
… Prior data suggested that IL-18 would exacerbate immunopathology in EAE. Instead, excess IL-18 was profoundly protective. Excess IL-18 did not impair CD4Tauto priming or early expansion. Rather, it selectively restricted later accumulation of highly activated, splenic CD4Tauto bearing CNS-homing …
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The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome
… thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, …
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The role of IL-4Ra during acute schistosomiasis
During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is …
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Effect of Lactoferrin to Increase Drug Permeability of Primary Pulmonary Mycobacterial Granulomas
… the challenges that come with this specific immunopathology. We hypothesized that by altering the immunopathology of granulomas using lactoferrin, an immunomodulating agent, it will allow greater penetration of therapeutics into the site of focal inflammation. Our lab has reported that oral …
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Equine Protozoal Myeloencephalitis: investigating immunopathogenesis and treatment efficacy in mouse models and clinically affected horses
… were employed to extensively evaluate the immunopathology of spinal cord tissue samples collected from EPM affected horses. A novel in-situ hybridization technique was successfully utilized to identify S. neurona in tissue samples collected from horses with EPM. This technique will create …
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Modifying the lung microenvironment through gene delivery of immunomodulatory cytokines
… immune system, all have the potential to lead to immunopathology. Immunopathology is characterised by intense inflammation, including overproduction of cytokines, reactive oxygen species, and significant infiltration of immune cells to the injury site. In some patients, this heightened immune …
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A Novel Mechanism of Enhanced Susceptibility to Bacterial Pneumonia in Influenza-infected Hosts
… use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested to contribute to these poor outcomes. Using Streptococcus pneumoniae in a wellestablished murine model of SBP following influenza, we stratified disease severity based on …
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Psoriasis activation of cells important in cardiovascular disease
… have been heavily implicated in psoriasis immunopathology. Significant upregulation of epidermal IL-36 is a recognised characteristic of psoriatic skin inflammation. IL-36 induces inflammatory responses in dendritic cells, fibroblasts and epithelial cells. While vascular alterations are a …
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DIABETES MELLITUS AND THE DYSREGULATION OF ANGIOGENESIS IN TUBERCULOSIS
… outcomes. Angiogenesis plays a key role in TB immunopathology by supporting mycobacterial survival within granulomas, whereas DM-associated oxidative stress impairs normal angiogenic processes. I hypothesized that disrupted angiogenic regulation underlies the worsened outcomes observed in DM-TB …
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The Development and Function of Memory Regulatory T Cells
… TReg cell-mediated suppression can also reduce immunopathology at sites of infection, which can occur as a result of a vigorous anti-pathogen immune response. </p><p>In contrast to chronic infection, how TReg cells behave and function following acute infections remains largely unknown as, to …
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TISSUE ARCHITECTURE AND INTERCELLULAR COMMUNICATION: MEDIATORS OF PROTECTIVE OR PATHOGENIC INTERFERON RESPONSES
… protecting from pathogeninsult while limiting immunopathology. Previous work has defined how anatomical structures and regulation of immune responses by resident immune cells contribute to this balance. However, the contribution of tissue-resident non-immune cells within these barriers remains …
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Dendritic cell regulation of immunity to Leishmania donovani
… infection in man. Associated with profound immunopathology and chronic immune suppression, visceral leishmaniasis is endemic to some of the world’s most resource-poor regions. There is no vaccine and current therapeutic options are limited by parasite resistance, high toxicity and …
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… phagocytes in shifting the balance between immunopathology and protective immunity. By omitting antibiotic therapy from the superinfection model, we show that IL-10 also impairs bacterial clearance, specifically when the IL-10Rα gene is ablated in interferon-I-responsive monocytes. …
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