Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Immunomodulatory properties"”.
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Characterisation of the immunomodulatory properties of human natural killer T cells
… by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist α-galactosylceramide (αGalCer) in murine models. However iNKT cell based immunotherapies have proved disappointing in phase I and II clinical trials to date. Humans have a wider repertoire of …
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The immunomodulatory properties of Vitamin D in vitro and in vivo
… D insufficiency and deficiency. Vitamin D is an immunomodulatory molecule which induces the synthesis of antimicrobial peptides and anti-inflammatory molecules, and inhibits pro-inflammatory cytokine synthesis. The overall goal of this work was to investigate immunological differences between SS …
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The immunomodulatory properties of AZT used in the treatment of AIDS
AZT (3'-azido-2’, 3’-dideoxythymidine) has been shown to prolong the survival of patients infected with human immunodeficiency virus (HIV) and decrease the severity of opportunistic infections. Such studies have prompted the use of AZT to treat symptomless individuals infected with HIV in the hope …
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The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function
… hosts and have powerful anti-inflammatory properties which are shown to have therapeutic effects on inflammatory diseases. Using products derived from the helminth parasites Fasciola hepatica and Ascaris lumbricoides we investigated the mechanism by which these responses are induced. …
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Mechanistic and synergistic actions of the in vitro antimycobacterial and immunomodulatory properties of Knowltonia vesicatoria (L.f.) Sims
… compounds from this plant. The antimycobacterial properties of these compounds have not been reported earlier. The sterol was the most active sample against a drug-sensitive strain of M. tb with a minimum inhibitory concentration (MIC) of 50.00 μg/mL. The extract of K. vesicatoria was tested …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… neuroprotective effect in PD models and its immunomodulatory activity as the underlying mechanism of neuroprotection. The neuroprotective activity of MDG548 was assessed in vivo in the subacute MPTP model and in the chronic MPTP/probenecid (MPTPp) model of PD. MDG548 activity on microglia …
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THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS
… fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids.
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Can Mesenchymal Stem Cells Inhibit the Formation of Saccular Aneurysms?
… are pluripotent cells that have interesting immunomodulatory properties and have been studied in the context of many inflammatory diseases. Few studies have addressed aneurysms and suggest that these cells have the potential to be adjuvants to current treatment modalities in treating fully …
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The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant
… laboratory has shown in vitro that CRN has some immunomodulatory properties. To further delineate the immunomodulatory properties of CRN, we used real time-polymerase chain reaction and immunohistochemical staining to determine the mRNA and protein expression of tumor necrosis factor-α (TNF-α), a …
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Effects of Dietary Immunomodulation on Parasite Load in Commercial Crossbred Lambs
… These results indicate that CelmanaxRTM has immunomodulatory properties, but may not have absolute effects on clearing helminth infections in Texel crossbred lambs.
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… the advent of multiple treatment options such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PI), CAR-T therapy and antibody-based therapies have improved the prognosis of MM, all patients eventually relapse due to the presence and development of drug resistance. Therefore, the …
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Engineering B Cells For Use In Immunotherapy and Cancer
… a protocol for the expansion of Bregs with immunomodulatory properties for cell therapy. We hypothesized that using genetic engineering tools we can skew the function of B cells toward a suppressive phenotype and support their ex vivo proliferation and survival to generate a viable subset of …
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Antimicrobial and immuno-modulatory peptides as a treatment for lung disease and delivery by nebulisation
… potential due to their antimicrobial and/or immunomodulatory properties. The project aim was to assess the therapeutic potential of several snake-derived AMPs and to evaluate the suitability of peptide delivery by nebulisation.<br/><br/>In in vitro assays the peptides exhibited antimicrobial …
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The effect of small molecule analogues of the immunomodulatory helminth product ES-62 on denritic cell responses
… (PC) is responsible for many of the immunomodulatory properties of this molecule and as ES-62 is potentially immunogenic, and therefore unsuitable as a drug, a library of small molecule analogues (SMAs) of ES-62 based on its PC moiety has been synthesised. The aim of this project was …
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Effect of phosphorylcholine-based small molecule analogues of the immunomodulatory nematode product ES-62 on mast cell function
… Acanthocheilonema viteae has a plethora of immunomodulatory properties. By virue of its PC moieties ES-62 has been shown to be anti-inflammatory in nature having the ability to reduce arthritis and asthma in animal models. With respect to this project, it was also shown that ES-62 prevented …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
… We also discovered that AFS cells possess immunomodulatory properties and are able to inhibit lymphocyte activation by release of soluble factors in vitro. This quality makes AFS cells an ideal candidate for cell-based immunomodulation in early stages of T1DM to prevent the autoimmune …
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Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response
… Lactoferrin is an iron-binding glycoprotein with immunomodulatory properties that decrease tissue damage and promote Th1 responses. Mice challenged with TDM and treated with lactoferrin had decreased size and numbers of granulomas at the peak of the granulomatous response, accompanied by increased …
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Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
… (Paper III). In conclusion, the discovered immunomodulatory properties of these HDPs clearly indicate their potential for the development of new treatments for bacterial infections. Finally, a novel role of the abundant plasma protein heparin cofactor II (HCII) in host defence was …
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Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of β2 Adrenoceptor Ligands
… stimuli, we quantified the pharmacological properties of affinity, efficacy, and potency for cAMP accumulation and ERK1/2 phosphorylation as surrogates of the Gs and βarr2 pathways, respectively, in selected β2AR ligands. Using these pharmacological parameters, we developed a mathematical …
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