Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Immunomodulatory activity"”.
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Evaluation of the immunomodulatory activity of Plasmodium falciparum hsp70-1
… The current study sought to investigate the immunomodulatory role of PfHsp70-1. A recombinant form of the protein was produced in three bacterial expression hosts (E. coli XL1 Blue, E. coli ClearColi BL21 and Brevibacillus choshinensis). The protein was expressed attached to an N-terminal …
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IMMUNOMODULATORY ACTIVITY OF TAMOXIFEN AND RALOXIFENE IN MACROPHAGES: IMPLICATIONS FOR HOST-DIRECTED THERAPIES IN INFECTIOUS DISEASES
Tamoxifene (TAM) e raloxifene (RAL) sono modulatori selettivi del recettore degli estrogeni (SERMs), ampiamente prescritti per il trattamento di patologie dipendenti dal recettore degli estrogeni α (ERα), come il tumore al seno ERα-positivo e l’osteoporosi. Recentemente, questi farmaci hanno …
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… for modulation of pro-inflammatory immune activity with minimal IEC impact in the absence of a pro-inflammatory challenge. This modulation may be mediated through induction of negative regulators of innate immunity (ATF3, TRIB3, DUSP1) and through changes in global histone acetylation …
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Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge
Immunomodulatory effects of lactic acid bacteria vary with strain and may vary with growth phase and medium. The ability of different lactobacilli strains (Lactobacillus helveticus R0052, L. rhamnosus R0011, L. rhamnosus GG) at different growth phases to modulate macrophage and intestinal …
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Synthesis and Evaluation of Biological Activity of a Potential Immunomodulatory Zwitterionic Polysaccharide
… synthesis of a PSA1 analogue and evaluating its immunomodulatory activity. Also discussed are the synthesis and the chemical reactivity of 3,6-anhydro-D-glucal which was formed unexpectedly in the synthesis of L-rhamnal.</p>
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A role of statins against listeria monocytogenes and Mycobacterium tuberculosis infection
… (Mtb) in murine macrophages. We show prominent immunomodulatory activity induced by statins, mainly increased phagosomal maturation and autophagy resulting in decreased bacterial growth in macrophages. Subsequently, statin†treated mice showed decrease in bacterial loads, accompanied by reduced …
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The influence of ECM on mesenchymal stromal/stem cell activity and their interactions with monocytes/macrophages
… MSC morphology, proliferation, migration, and immunomodulatory activity. Notably, MSCs within these 3D environments exhibit differential responses to pro-inflammatory stimuli, with the ECM potentially acting as a reservoir for secreted cytokines and growth factors, orchestrating cellular …
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The use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.
… various infections. It has been claimed to have immunomodulatory actions that potentiates the body's immune response. The immunomodulatory activity of SeptilinTM has not been well investigated via appropriate in vitro models. Therefore this study was undertaken to investigate the in vitro effects …
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Immunomodulatory effect of the Acanthocheilonema viteae product ES-62 in arthropod extract models of asthma
… of allergy induction. ES-62 displayed some immunomodulatory activity at 1 μg/dose in the CRE allergy model. Specifically, CRE allergy-amplified Interleukin-4 (Il4), Il13 and Ifng pulmonary gene expression was reduced with ES-62 treatment.;ES-62 also decreased the level of peribronchial …
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Investigating cestode modulation of host neuronal excitability and cell-type-specific gene expression in an in vitro mouse model of neurocysticercosis
… alone or in combination with LPS to evaluate its immunomodulatory activity. The T. crassiceps homogenate blocked the induction of pro-inflammatory transcriptional activity across different cell types when added to LPS. This suggested that it likely acts up-stream of the toll-like receptor 4 …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… neuroprotective effect in PD models and its immunomodulatory activity as the underlying mechanism of neuroprotection. The neuroprotective activity of MDG548 was assessed in vivo in the subacute MPTP model and in the chronic MPTP/probenecid (MPTPp) model of PD. MDG548 activity on microglia …
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Effects of dietary fiber components and gut microbiota products on the immune system: a focus on grape pomace as a novel source of fermentable substrates and bioactives
… utilizing in vivo and in vitro approaches. Immunomodulatory activity of the Lacticaseibacillus rhamnosus R0011 secretome in combination with retinoic acid was examined using a human antigen-presenting cell (APC) model. These metabolites drove APC differentiation into a tolerogenic …
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A study of the immune response in murine experimental malaria, with special reference to the effects of South African medicinal plants, artesunate and chloroquine
… of IL-10. Artesunate displayed enhanced IL-1 0 activity but no effect on production of pro-inflammatory cytokines. Extracts of W. salutaris, a South African medicinal plant, reduced parasitaemia by >50% at doses of 100 and 500mg/kg, and of A. annua reduced parasitaemia by 64% at a dose of 200 …
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A neutral protease of the neutrophil surface : role in the proteolysis of C-reactive protein and fibrinogen
… This protease also possessed fibrinogenolytic activity. The fibrinogen degradation products generated by this neutrophil membrane-associated protease were distinct from the products generated by the fibrinogenolytic systems of plasmin, human neutrophil elastase and neutrophil lysosomal enzymes …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… has evolved mechanisms to precisely regulate PRR activity. This is accomplished in part through the activity of immunomodulatory cytokines. </p><p>Interferons are a group of cytokines notable for their ability to shape immune responses. To some extent, this is accomplished through their ability to …
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The functions of pregnancy-associated plasma protein A in rheumatoid arthritis.
… and reports of possible proteinase inhibitory activity and immunomodulatory activity suggested that it may be an antiarthritic agent, involved in the amelioration of rheumatoid arthritis (RA) observed during pregnancy.PAPP-A has been purified from late pregnancy plasma using ammonium sulphate …
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An investigation into placental protein 14, a modulator of the immune response associated with human reproduction.
… procedure and an investigation of the activity of the protein. In addition the cDNA coding for the protein was cloned and expressed as a recombinant fusion protein and the molecular structure of the protein was predicted and analysed using computer-assisted modelling. Finally the …
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The Association Between The Il-1 Pathway
… production interleukin(IL)-1α/β. IL-1 conducts immunomodulatory activity through tumor-associated fibroblasts and locks in the turnkey position of the immunosuppression pathway to resist the cytotoxic T lymphocyte function. Hence, IL-1 is a key target of interest in treating melanoma, along with …
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Assessment of blue whiting protein hydrolysate bioactivities using cell culture models
… of eleven different BWSPHs. Cellular bioactivity analysis of these eleven hydrolysates indicated that none of the BWSPHs tested exhibited satiating activity, antioxidant activity, immunomodulatory activity or anti-obesity activity as measured using specific cellular models. However, six …