Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 319 for “"Immunomodulatory"”.
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Immunomodulatory effects of LL-37 in the epithelia
The cationic host defence peptide LL-37 is an immunomodulatory agent that plays an important role in epithelial innate immunity. Previously, concentrations of LL-37 thought to represent levels present during inflammation have been shown to elicit the production of cytokines and chemokines by …
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Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1
<p><strong>Background</strong> Sialic acids are key sugar moieties located at the non-reducing terminals of glycan chains on glycoproteins and glycolipids. By virtue of their location, they influence the functions and biochemical properties of the macromolecules they are bound to. Removal of sialic …
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Immunomodulatory effect of pneumolysin upon CD4 T cells
… investigated a potentially novel pneumococcal immunomodulatory mechanism involving the effect of the pneumococcal toxin, pneumolysin, upon the cells at the heart of the adaptive immune response; the CD4 T cell. I generated purified pneumolysin and a purified pneumolysin mutant called F433 to …
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Innate immunomodulatory strategies and pathogenic basis for nidoviruses
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Evolutionary History of Immunomodulatory Genes of Giant Viruses
… in host-virus interactions are involved in immunomodulatory processes and have homology to proteins encoded by the host. These viral genes, often referred to as "mimics", are therefore believed to be the result of host-to-virus gene transfer. In this study I sought to examine if common …
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Platelets and their immunomodulatory roles during Streptococcus pyogenes infection
Sepsis and invasive bacterial infection is a major cause of human disease and death worldwide. Streptococcus pyogenes is one of the major pathogens responsible for bacterial infections, which range from mild to severe and life threatening conditions. S. pyogenes contains a cell wall anchored M …
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Characterization and Immunomodulatory Function of Human Mesencymal Stem Cells
"중간엽줄기세포는 처음에는 골수 내에만 존재하는 것으로 알려져 왔으나 최근 많은 연구와 실험을 통해 그 외 다양한 성체조직에서도 분리배양이 가능하게 되었다. 중간엽줄기세포는 연골세포, 지방세포, 골세포, 신경세포 등 다양한 조직으로 분화할 수 있는 능력 외에도 면역조절 기능이 있는 것으로 알려져 있다. 본 연구에서는 골수, 지방조직, 제대혈, 탯줄의 Wharton's jelly에서 유래된 중간엽줄기세포의 특성 및 면역조절능력을 비교하였고, 면역조절에 관여하는 인자의 기작을 확인하여 향후 면역질환의 치료에 있어서의 임상적 유용성을 …
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The potential immunomodulatory effects of the statins in uveitis
… Further, the study investigated the potential immunomodulatory role of the group of compounds known as the statins as adjunctive or steroid-sparing therapy in uveitis. The data recorded provides evidence for the potential of statins in the treatment of uveitis as a steroid-sparing monotherapy …
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Immunomodulatory Effects of Diethylstilbestrol During Prenatal and Adult Life
… critical gaps in the literature, we examined the immunomodulatory effects of adult and prenatal exposure to DES in males and females. Our findings show that DES effects were evident in both the thymus and spleen. DES markedly affected the apoptosis of thymocytes and the ability of splenic …
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Immunomodulatory biomaterials to promote early transplant integration and wound healing
… mediating these complications is the delivery of immunomodulatory factors that are able to accelerate wound healing and tissue integration through the local recruitment and education of anti-inflammatory, pro-regenerative subsets of immune cells that work to enhance tissue regeneration and …
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Evaluation of the immunomodulatory activity of Plasmodium falciparum hsp70-1
… The current study sought to investigate the immunomodulatory role of PfHsp70-1. A recombinant form of the protein was produced in three bacterial expression hosts (E. coli XL1 Blue, E. coli ClearColi BL21 and Brevibacillus choshinensis). The protein was expressed attached to an N-terminal …
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Plant-delivered Cholera Toxin B subunit as an Immunomodulatory Molecule
<p>The B subunit of cholera toxin (CTB) functions as an effective mucosal carrier molecule of chemically or genetically conjugated antigens. Orally delivered CTB or CTB fusion protein binds to G<sub>M1</sub>-ganglioside receptor molecules located on cells in the gutassociated lymphoid tissues, the …
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Characterization of novel immunomodulatory proteins encoded by parapoxvirus ORF virus
… Medicine as a preventive and therapeutic immunomodulatory agent. However, the functions (genes, proteins, and mechanisms of action) involved in immunomodulation remain poorly understood. ORFV establishes infection of keratinocytes in a proinflammatory environment triggered by skin …
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Investigations into the vaccinia virus immunomodulatory proteins C4 and C16
Vaccinia virus (VACV) is the most intensively studied orthopoxvirus and acts as an excellent model to investigate host-pathogen interactions. VACV encodes about 200 proteins, many of which modulate the immune response. This study focusses on two of these: C16 and C4, that share 43.7 % amino acid …
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Modifying the lung microenvironment through gene delivery of immunomodulatory cytokines
… area. In this thesis, I investigated the use of immunomodulatory cytokines with anti-inflammatory properties to modulate lung microenvironment. Through the novel genetic tools l have generated, such as the inducible transgenic mouse and the gene delivery system using adeno-associated vectors, I …
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Liposome-anchored local delivery of immunomodulatory agents for tumor therapy
… exposure. We hypothesized that by anchoring immunomodulatory agents to lipid nanoparticles we could retain the bio-activity of therapeutics in the local tumor tissue and tumordraining lymph node, but limit systemic exposure to these potent molecules. We first prepared liposomes bearing …
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Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies
… we enable rational design of next-generation immunomodulatory biomaterials.
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Utilizing the Immunomodulatory Effects of Electroporation for Treating Brain Tumors
… glioblastoma. We are proposing to utilize the immunomodulatory effects of electroporation treatments to improve the outcomes of immunotherapies in the brain.
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