Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Immunomodulator"”.
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Optimizing immunomodulator and anti-TNF treatment in Inflammatory Bowel Diseases.
Contains fulltext : 297656.pdf (Publisher’s version ) (Open Access)
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The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant
… laboratory has shown in vitro that CRN has some immunomodulatory properties. To further delineate the immunomodulatory properties of CRN, we used real time-polymerase chain reaction and immunohistochemical staining to determine the mRNA and protein expression of tumor necrosis factor-α (TNF-α), a …
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Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal Pneumonia Virus of Mice.
Respiratory syncytial virus (RSV) is the major causative agent of acute lower respiratory tract infections in infants and young children. Unfortunately, there are no licensed RSV vaccines available, and the few treatment options for high-risk individuals are either extremely costly or cause severe …
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Evaluation of Pgg-Glucan, a Novel Immunomodulator, in in Vitro and Ex Vivo Models of Equine Endotoxemia
Justification - Endotoxemia is an important contributor to mortality and loss of use in the horse and results in significant losses to the equine industry on an annual basis. Objective - To determine the effect of PGG-Glucan on the cytokine response to endotoxin in the horse. Animals - Part 1; 6 …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by …
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Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
… on M2's molecular functioning as a viral immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular protein, this suggests a …
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The effects of topical calcipotriol treatment on immune responses to vaccination
1,25-dihydroxyvitamin D3 (Vitamin D) is a potent immunomodulator capable of generating regulatory T cells (Tregs) and contributing to immune tolerance. Additionally, vitamin D has been shown to promote mucosal immunity when used as a vaccine adjuvant. We show here that pretreatment of an area of …
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… for pH-responsive intracellular delivery of the immunomodulator R848 (or Resiquimod), a poorly soluble adjuvant for a melanoma vaccine. Third, nanodroplets of one of the liquid polymers were embedded in mucoadhesive wafers and were evaluated for spatially defined drug delivery to engineered …
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biological treatment options of multiple myeloma
… conjugates along with steroids, and immunomodulatory therapies. Bortezomib, Carfilzomib, and Ixazomib are examples of proteasome inhibitors. Bortezomib is the predominant choice in treatment regimens. The basic action of proteosome inhibitors is to inhibit the degradation of proteins …
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Characterization of CEACAM1 Spatial Distribution, Self-association and Dynamics using High-resolution Microscopy Techniques
… given its potential as a tumour suppressor and immunomodulator, CEACAM1 is being targeted for clinical development. However, there remain clear challenges owing to the observation that different CEACAM1 isoforms display cell-type specific expression patterns under different physiological …
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Membrane-Bound Immunomodulators As Adjuvants In A Cell Culture-Based Avian Influenza Vaccine
… cytokine to the antigen of interest keeps the immunomodulator in close contact with the antigen ensuring that immune cells recruited or activated by the adjuvant react with the antigen as well. Influenza can be used to test this model since its surface proteins HA and NA contain conserved …
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Quantifying the Effect of Vitamin D Deficiency and Alcohol Exposure on Immune Response to Mycobacterium Infection
… in the future to aid in the identification of immunomodulator associated therapies to enhance host immune response to TB.
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The Impact of Vitamin D on the Epidemiology, Pathogenesis, and Treatment of Esophageal Adenocarcinoma
… outcomes. Vitamin D is a hormone that acts as an immunomodulator and regulator of cellular proliferation with anticancer properties, and has been implicated in the prevention of some cancers. Its main source in light skinned individuals is the sun, and there is an epidemiological association …
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Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation
… induced by exposure to a natural immunomodulator, estrogen. In this novel study, we have comprehensively investigated the effect of estrogen on IL-17 induction, an aspect not studied thus far. We are the first to demonstrate that estrogen increases the ability of lymphocytes to …
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Tailored influenza virus vaccines for both the young and old: Vaccine Efficacy of Whole Inactivated Vaccines bearing Immunomodulatory Adjuvants or Multimeric peptides
… (WIV) bearing bioactive membrane-anchored immunomodulatory proteins such as cytokines on the virion surface, collectively known as CYT-IVACs (Cytokine bearing-Inactivated Vaccine). In addition, we tested whether a multimeric M2e peptide presented on WIV can serve to enhance immunogenicity …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… therapies developed rely on immunosuppressant or immunomodulator molecules and come with risk of infection, high costs, and toxic, uncontrolled side effects. Those diagnosed maintain a significant unmet need for targeted therapies.</p> <p>There is increasing evidence towards non-immune cell types …
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CHEMOENZYMATIC APPROACHES TO THE PREPARATION OF BIOLOGICALLY ACTIVE COMPOUNDS
… pimecrolimus, its 32-epi chlorine analogue, an immunomodulator useful for the treatment of inflammatory skin diseases. The advantage offered by enzymes, showed to be not only their ability to regioselective discriminate between the two secondary hydroxyl groups, but also, their chemoselectivity, …
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Therapeutic drug monitoring of anti-TNF biologics in patients with Crohn's disease at Groote Schuur Hospital, Cape Town, South Africa
… TDM. Forty seven (90%) were treated with an immunomodulator prior to starting anti TNF therapy. The median time from initiation of anti TNFs to first TDM was 9.5 months (IQR5-35); 35 patients (67%) had sub-therapeutic trough levels at that time. No significant predictors of sub-therapeutic …
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Airway inflammation, diagnosis, perception of asthma, and sputum zinc levels in a community cohort.
… research establishing the role of zinc as an immunomodulator in asthma. Mouse models have demonstrated that zinc deficiency is associated with airway eosinophilia. Two pools of zinc exist in the body: largely fixed, enzyme-bound zinc, and free or labile zinc, the biologically active component. …
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Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles
… tumor necrosis factor (a critically important immunomodulator), and that they can traffic from peripheral sites to draining lymph nodes via lymphatic vessels. Furthermore, extensive biochemical characterization of purified mast cell-derived particles was performed. Finally, evidence is …
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