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Showing 1 to 20 of 92 for “"Immunomodulation"”.
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Immunomodulation by vasopressors
Contains fulltext : 249034.pdf (Publisher’s version ) (Open Access)
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Polysequence Nanomaterials for Immunomodulation
<p>Peptide-based vaccines have received growing interest due to their specificity and ability to limit off-target effects, and they are currently being explored toward a variety of infectious diseases and therapeutic targets. However, the efficacy and applicability of such epitope-based vaccines …
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
Many viruses can infect the liver and persist there as their site of primary infection. The clinical outcomes in viral hepatitis can range from complete pathogen clearance and recovery of liver function to failure to contain the infection and loss of liver function. Because hepatotropic viruses are …
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Maternal Immunomodulation of Neonatal Alloantigen Response
… an apparent state of immunologic privilege, immunomodulation of the neonatal immune response was attempted through manipulations of cell-mediated reactions in vitro that were thought to represent possible in vivo phenomena. Through mixed lymhocyte culture experiments, neonatal immune cells …
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Vitamin D and Immunomodulation in Bronchial Asthma
Asthma is one of the most common chronic inflammatory diseases of the airways. The chronic inflammation is associated with airway hyperresponsiveness (AHR), airway obstruction and airway remodeling. In asthmatics the airway epithelium produces increased amounts of proinflammatory cytokines …
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Immunomodulation of Flavonoid Biosynthesis in Transgenic Arabidopsis thaliana
In an effort to test the feasibility of intracellular expression of enzyme-targeted antibodies to alter metabolism, recombinant antibody fragments in the single-chain format (scFv) were isolated from a phage display library using Arabidopsis chalcone isomerase (CHI) of the flavonoid biosynthetic …
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Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
Recognition of polymicrobial infections is becoming important for understanding differential host responses to environmental exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model of infectious colitis with particular usefulness for modeling human …
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Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
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Effects of Dietary Immunomodulation on Parasite Load in Commercial Crossbred Lambs
… effects of parasitism on their flocks. Immunomodulation has been used in many autoimmune diseases in an effort to downregulate the immune system and alleviate pathology. However, upregulation of immune responses by use of dietary immunosaccharides may allow parasite susceptible sheep to …
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Ricin B Chain-Insulin Fusion Protein Immunomodulation of Type 1 Diabetes
<p>Type 1 diabetes mellitus (T1D) is a debilitating chronic inflammatory disease of the insulin-producing pancreatic islet β-cells that results from a combination of genetic and environmental factors. Attempts to suppress Th1-mediated autoimmune diseases such as T1D by mucosal delivery of …
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T cell Immunomodulation in the Lymph Node for Inhibition of Load-Induced Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease that affects millions of people worldwide. The molecular mechanisms of OA initiation and progression are poorly understood and currently, no disease-modifying treatments exist. Intra-articular injection of anti-inflammatory therapeutics is a …
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Gene expression patterns of the female genital tract and immunomodulation by Lactobacillus species
Inflammation in the female genital tract (FGT) is associated with increased HIV-1 viral replication, HIV-1 transmission and HIV-1 acquisition. The optimal commensal Lactobacillus bacterial species is associated with reduced inflammation in the FGT and dampened immune responses to non-optimal …
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Priming systemic anti-tumor immunity via in situ immunomodulation of the tumor microenvironment
… immune cells primed after intratumoral immunomodulation can traffic to distant sites of metastasis leading to tumor regressions at injected and non-injected lesions. The intratumoral in situ vaccination approach is amenable to a variety of therapeutic modalities ranging from small …
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Hypoxic immunomodulation results in increased disease risk and altered behavior via non-canonical pathways
Hypoxia is a potent immunomodulatory condition that underlies a wide array of disease states and associated comorbidities. Inflammation appears to be a critical factor in the adverse psychological outcomes linked with hypoxia/reoxygenation injury. A causative role for brain-based IL-1 has been …
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Building blocks for regenerative medicine : vascularized models and immunomodulation to engineer hepatic cell therapies
Despite significant advances in our knowledge about liver pathology and regeneration, non-palliative regimens for most end-stage liver disorders are limited. The only definitive treatment for end-stage liver failure is an orthotopic liver transplant. Unlike other major causes of mortality, death …
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Human immunodeficiency virus (HIV)-mediated cardiac fibrosis: implication of cellular immunomodulation and cytokine profile alterations
… inflammation, which in turn disrupt cellular immunomodulation and increase susceptibility to cardiac fibrosis. To test this hypothesis, we evaluated changes in T-cell subsets (T-helper cell 1 (Th1) and T-helper cell 2 (Th2)), monocyte/macrophage subsets (macrophage type 1 (M1) and macrophage …
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Effets d'une immunomodulation de la leptine et de la cholécystokinine chez le rat en croissance
… the activity of existing endocrine factors is an immunomodulation. The meal-related intestinal signal cholecystokinin (CCK) and the adipose tissue-produced leptin are known as satiety hormones. Their interaction induces long- and short-terms effects. The aim of this study is to examine the …
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Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
… allergic airway inflammation and Flt3-L-induced immunomodulation were examined in a mouse model of allergic asthma.|Two dendritic cell subsets, CD11chighCD11blow and CD11clowCD11bhigh, with distinct expression of CD8α, B220, CD19, F4/80, MHC II, CCR7, CD40, PDL1, PDL2, CD80, and CD86, were …
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
<p>Allergen-induced asthma is the leading form of asthma and a chronic condition worldwide. Common allergens are known to contribute to the pathogenesis of this disease. Murine models of allergic asthma have mostly used an intraperitoneal route of sensitization (not airway) to study this disease. …
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