Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Immunology of Infectious Disease"”.
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Characterizing the early stages of a novel host shift using host fitness and metabolomics
… that contribute to successful colonization of a novel host species by a pathogen remain unclear. One likely factor determining host shift success is the early interaction between host and pathogen at the very moment of the host shift event. How does a novel host respond to a pathogen insult …
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
… initiates the antibody diversification processes of somatic hypermuntation (SHM) and isotype class switch recombination (CSR). AID is targeted to the immunoglobulin gene locus where it deaminates cytosines to generate uracil residues in DNA. This generates guanine-uracil (U:G) mismatch lesion …
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Enhancement of Hiv Persistence By Adipose Tissue
… challenge for HIV eradication is the persistence of cellular and anatomic viral reservoirs. The primary cellular reservoirs for HIV, memory CD4 T cells and macrophages, traffic into various tissues where most viral replication occurs, or in the case of virally-suppressed antiretroviral-treated …
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Understanding Primate Immunity to African Trypanosomes Through the Characterization of Trypanosome Lytic Factor Formation and Function
<p>African trypanosomes cause an annual loss of over 1 billion USD due to their economic and agricultural burden in Sub-Saharan Africa. These parasites are unicellular, extracellular parasites, that infect humans, cattle, and other livestock. Humans and some non-human primates are protected against …
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The Role of Dual Specificity Phosphatase -11 In Innate and Adaptive Immune Responses
<p><strong>THE ROLE OF DUAL SPECIFICITY PHOSPHATASE -11 IN INNATE AND ADAPTIVE IMMUNE RESPONSES</strong></p> <p><strong>Kalyan Chakravarthy Nallaparaju, M.S.</strong></p> <p><strong>Supervisory Professor: Chen Dong, Ph.D</strong>.</p> <p>Dual-specificity phosphatases (DUSPs) constitute a subfamily …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
The predominant route of human immunodeficiency virus type 1 (HIV-1) transmission is infection across the vaginal mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV …
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Investigating The Roles of Lung Epithelial Stat3 In Therapeutically Inducible Resistance to Acute Bacterial Pneumonia.
<p>Investigating the roles of lung epithelial STAT3 in therapeutically inducible resistance to acute bacterial pneumonia.</p> <p>Vikram Vitthal Kulkarni, M.S.</p> <p>Advisory Professor: Scott Evans, MD.</p> <p>The lung epithelium is a dynamic tissue capable of displaying structural and functional …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… is under investigation for the treatment of cancer. Evidence indicates adenoviruses induce autophagy that is required for oncolysis, but the molecular regulation of autophagy in infected cells remains under investigation. Our data suggested the canonical pathway regulating …
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The Role of The C5A Receptor In Host Defense Against Listeria Monocytogenes
… (Lm)<em> </em>is a major cause of mortality resulting from food poisoning in the United States. While the complement component C5 is known to be protective in listeriosis, it is unknown how its cleavage fragment C5a participates. Here we show in a model of systemic Lm<em> …
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Characterizing The Regulation of Candida Albicans Hyphal Morphogenesis In The Context of Host Macrophages
… on the skin, mucosal surfaces, and in the gut of an estimated 80% of individuals. Though generally harmless, <em>C. albicans</em> is capable of causing uncomfortable mucosal infections as well as deadly disseminated infections depending on the immune status of the host. Although antifungal …
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T-cell Dysfunction by HCV Core Protein Involves PD-1/PD-L1 Signaling.
… C virus was identified as a significant cause of post-transfusion hepatitis. Nearly two decades later there is still no vaccine, inadequate treatment options, and limited understanding of how the virus establishes chronicity in the majority of the people it infects. Recent reports suggest that …
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Comprehensive Investigation into the Molecular Mechanisms Driving the Emergence of emm4 Group A Streptococcus
… the Molecular Mechanisms Driving the Emergence of <em>emm4</em> Group A <em>Streptococcus</em></strong></p> <p>Chioma Modeline Odo, M.S.</p> <p>Advisory Professor: Samuel A. Shelburne, MD, Ph.D.</p> <p>The major gram-positive bacterium group A <em>Streptococcus</em> (GAS) is a model organism for …
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Synthesis and Evaluation of Biological Activity of a Potential Immunomodulatory Zwitterionic Polysaccharide
… fragilis</em> is an integral component of the normal gastrointestinal flora. The bacterium colonizes the intestinal tract of human beings as it has no reservoir other than mammals. An unprecedented proportion of the genomic DNA of <em>B. fragilus</em> is involved in the production of …
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Viral Factors Influencing Early Infection Events During Ex-Vivo KSHV Infection
<p>The enigma of Kaposi Sarcoma Herpes Virus infection, and its persistence despite a quarter century of research on the virus, has given rise to an immediate need for addressing fundamental questions about basic immunology and virology knowledge regarding this virus. Kaposi Sarcoma Herpes Virus …
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Utilization of Cholera Toxin B as an Adjuvant for the Subunit PspA Vaccine, Provides Effective Protection against Streptococcus pneumoniae Challenge
… to providing effective protection against infectious pathogens. Presently, two vaccinations exist in the market: PPSV<sub>23 </sub>and PCV<sub>13</sub>, which only protect against select 23 or 13 serotypes respectively of<em> Streptococcus pneumoniae</em> out of the possible 90. Researchers …
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The Prevalence of the Q-fever Agent Coxiella burnetii in Ticks Collected from an Animal Shelter in Southeast Georgia
… bacterium Coxiella burnetii. Ticks are vectors of the Q-fever agent but play a secondary role in transmission because the agent is also transmitted via aerosols. Most Q-fever studies have focused on farm animals but not ticks collected from dogs in animal shelters. In order to detect the Q-fever …
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Role of Vitamin-D3 and Retinoic Acid In A Human Thp-1 Macrophage Model of Mycobacterium Tuberculosis Infection
… and we investigated the activating effects of retinoic acid (RA) and vitamin D3 (VD) on macrophages in relation to the viability of Mtb. A combination of these vitamins (RAVD) enhanced the receptors on THP-1 macrophage (Mannose receptor and DC-SIGN) that increased mycobacterial uptake but …
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Impact of Temperature and Microbial Infection on the Honey Bee Hemocytes
… after E. coli challenge. A critical threshold of ~220,000 hemocytes/mL was identified; below this, survival dropped sharply, particularly in CLD/LP groups. Granulocytes (phagocytosis) and plasmatocytes (encapsulation) were most affected. Notably, 22°C alone stressed healthy bees but was …
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Lack of Inflammatory Response in Mouse Embryonic Cells to Listeria Infection
… in miscarriage, with a significant percentage of these losses attributed to failed implantation due to immunological challenges encountered by the early embryo. Recent research has shown that key cell types within mouse blastocysts, including embryonic stem cells (ESCs) and trophoblast stem …
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Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
… the immune dysregulation seen in some cases of COVID-19, the underlying viral mechanism by which these changes occur remains unclear. We hypothesize that viral proteins encoded by the SARS-CoV-2 RNA genome directly impact host chromatin to confer the observed immune-related transcriptional …
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