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Showing 1 to 20 of 642 for “"Immunohistochemistry"”.
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The use of collagen IV immunohistochemistry in the diagnosis of bullous pemphigoid
… and is technically sophisticated. Collagen IV immunohistochemistry is reported as a reliable test for the diagnosis of epidermolysis bullosa acquisita whereby It stains the roof of a subepidermal blister and would be expected on the floor in bullous pemphigoid. This technique could be performed …
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Uncovering the Immune Cell Landscape of Melanoma using Multiplex Immunohistochemistry and Computational Analysis
Contains fulltext : 283469.pdf (Publisher’s version ) (Open Access)
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ANALYSIS OF TUMOR SPECIFIC PROTEIN EXPRESSION IN GLIOBLASTOMA MULTIFORME (GBMs) TUMORS THROUGH IMMUNOHISTOCHEMISTRY
<p>GBM tumors are the most aggressive and, unfortunately, the most fatal form of brain cancer. GBM tumors with isocitrate dehydrogenase-1 (IDH1) mutation being expressed, lead to higher survival rates in patients that also have full resection of the tumor and chemotherapy. Without this mutation, it …
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Oesophageal squamous cell carcinogenesis : a study of cell cycle regulatory proteins by immunohistochemistry
Oesophageal squamous cell carcinoma (OSCC) is a highly malignant tumour that has a poor prognosis and shows marked regional variation in its incidence, implicating environmental factors. South Africa is one of several countries that has areas of high incidence. The exact aetiopathogenesis of OSCC …
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Morphological classification of childhood medulloblastomas with β-catenin immunohistochemistry and mycn fluorescent in situ hybridization
Medulloblastoma is the most frequently occurring childhood malignant brain tumour, affecting 1 of 5 children presenting with a brain tumour, between the ages of 0 and 9 years. The basic prognostic stratification that relies on clinical and histological findings alone has proven unsatisfactory as an …
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Feline Leukemia Virus Detection in Corneal Tissues of Cats by Polymerase Chain Reaction and Immunohistochemistry
Corneal transplantation carries a high rate of success in the domestic cat and is an indicated treatment for specific corneal diseases in this species. The potential for iatrogenic transmission of viral diseases is a well-recognized problem in human corneal transplantation programs and screening …
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Effect of Photoperiod on Developmental Morphology and Enolase Isoenzyme Immunohistochemistry in Rat and Djungarian Hamster Superficial Pineal Glands
<p>The best understood functional activity of the pineal gland is its diurnal production of melatonin in response to environmental lighting cues. Several enzymes of the melatonin pathway respond to daily photoperiod changes, for example hydroxyindole-O-methyltransferase (HIOMT) and serotonin …
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Immunohistochemistry for studying cyclic nucleotides in the central nervous system, with particular reference to guanosine 3',5'-monophosphate
… specificity however. Differences between RIA and immunohistochemistry, and different staining patterns with individual cyclic GMP antibodies, have been discussed as resulting from stereochemical differences between free and tissue -bound nucleotide. This may also explain why cyclic nucleotide …
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Osteogenesis During Early Healing Around Titanium and Titanium Zirconium Implants: Immunohistochemistry and mRNA Expression of Bone Markers in Miniature Pigs
<p><strong>Background: </strong>To better understand the effect of implant surface modification on bone, more information is needed on the early stages of bone healing around dental implants in vivo. Quantitative reverse transcription polymerase chain reaction (QRT-PCR) is a method that can be …
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The added value of BAP1 immunohistochemistry and fluorescence in situ hybridisation for CDKN2A/p16 and NF2 in the diagnosis and prognostication of pleural mesothelioma
… recorded and BRCA1-associated protein 1 (BAP1) immunohistochemistry (IHC) performed; a final diagnosis was sought from subsequent specimens and hospital records. The second retrospective study involved identification of all mesothelioma cases diagnosed over a 12 year period, with those patients …
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Atypical reactive lymphoid hyperplasia : a 5 year study with analysis of 10 cases for latent Epstein-Barr virus infection by in situ hybridization and immunohistochemistry
AIMS OF THE STUDY: 1. To perform a retrospective, epidemiological analysis of cases of reactive lymphadenopathy and atypical reactive lymphoid hyperplasia (ARLH) received in the Department of Anatomical Pathology, UCT and GSH, over a 5 year period, in order to determine the number of cases of ARLH, …
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A cell level automated approach for quantifying antibody staining in immunohistochemistry images. A structural approach for quantifying antibody staining in colonic cancer spheroid images by integrating image processing and machine learning towards the implementation of computer aided scoring of cancer markers.
… of antibody inside stained cell nuclei in immunohistochemistry images is proposed and demonstrated in this research. The system is based on a cellular level approach, where each nucleus is individually analyzed to observe the effects of protein antibodies inside the nuclei. The system …
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Identifying Children with Constitutional Mismatch Repair Deficiency (CMMR-D) Syndrome in the Expanding Lynch Syndrome population in Cape Town
… expression that can be identified by applying immunohistochemistry to formalin fixed paraffin embedded tissue sections. Use of MMR immunohistochemistry is established in the setting of Lynch syndrome (LS); however, the pattern of loss of staining in the background, non-tumour tissue is unique …
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
… white matter. We used in vivo MRI imaging and immunohistochemistry to investigate remote brain changes pre-surgery and one month after cortical ischemic stroke induced by distal middle cerebral artery occlusion in male C57BL/6J mice (stroke: n=5, sham: n=4). Cerebral blood flow (CBF) was …
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A study to investigate the role of P27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma
… by standard immunohistochemical techniques. Immunohistochemistry is cost effective, relatively easy to perform and will play more of a role in the future management of cancer. To investigate the role of p27 and cyclin E immunoexpression as a prognostic factor in early breast carcinoma. Cyclin …
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Radioresistance in oral squamous cell carcinoma
… methods of cell culture, microarray analysis and immunohistochemistry were employed to this end. Two novel radioresistant cell lines, PE-CAPJ41RR and PE-CAPJ49RR, were created and a number of targets identified using microarray analysis. Immunohistochemistry was used to investigate the …
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The Cardiovascular Effect of GLP-1 in Humans
… in the human cardiovascular system using immunohistochemistry with an extensively validated monoclonal antibody (mAb). There was no effect of GLP-1 on forearm blood flow, nor were systemic hemodynamics or cardiac output affected, and no binding of GLP-1R mAb was detected in vascular …
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Modulation of TGF-beta and extracellular matrix in retionic acid-induced cleft palate
… shelf growth and reorientation. However, using immunohistochemistry, RA-induced changes in these molecules could not be demonstrated.
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Localization of nerve growth factor-β in the stallion reproductive tract
… cells of the testis and the prostate gland. Immunohistochemistry on paraffin embedded paraformaldehyde fixed tissues was performed using a rabbit polyclonal anti-NGF-β antibody on a total of six male equine reproductive tracts, including a one-day old colt, a one-year old colt and 4 adult …
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