Global ETD Search
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Showing 1 to 3 of 3 for “"Immunoglobulin Light Chains"”.
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Structural determinants of cardiac light chain amyloidosis
Light chain amyloidosis (AL) is an acute systemic amyloid disease in which the overexpression and misfolding of immunoglobulin light chains leads to the formation of insoluble fibrils at critical organs in the body. The typical prognosis for AL patients is extremely severe—usually less than three …
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Regulation of Accessibility of the Variable Gene Segments of the Mouse Immunoglobulin Kappa Light Chain Gene Locus
… of the expression of antibody heavy and light chain molecules is required to fully explain the adaptive immune response. This involves understanding the mechanisms underlying the selection of individual Vκ genes for V-J joining. It has been assumed that this selection involves alterations …
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CD21 and CD24 Co-expression: A Translational Model between Mouse and Human
<p>Systemic Lupus Erythematosus and Rheumatoid Arthritis are B cell-mediated autoimmune diseases that afflict millions of people worldwide. B cell-targeted therapies for these diseases result in variable clinical outcomes. Thus, a need exists to better understand the dynamics of human B cell …