Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Immunogenomics"”.
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Decoding division: single-cell insights into the transcriptional, proteomic and metabolic regulation of proliferating CD4+ T-cells
… and regulate the immune response. Advances in immunogenomics have increasingly linked CD4+ T-cell activation to IMD pathogenesis, highlighting the importance of this process in disease. Upon activation, these cells undergo extensive and tightly regulated changes across multiple molecular …
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Tumor Immunotherapy: Mechanisms of Acquired Resistance and Characterization of Immune Related to xicities
… tumor. Using gene expression analysis, and immunogenomics, we determined the adaptations engaged by this melanoma to become completely resistant to triple combination T cell checkpoint blockade. Acquisition of immunotherapy resistance by these melanomas was driven by the coordinated …
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Understanding the role of CD4+ T cells in common immune-mediated diseases
Immune-mediated diseases such as autoimmunity are complex traits which collectively affect around 10% of the European population. Genome-wide association studies (GWAS) have demonstrated that genetic susceptibility to these diseases is explained by thousands of loci spread throughout the genome, …
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Mismatch Repair Deficient Neoantigen and Associated Circulating T-Cell Receptor Repertoires in Lynch Syndrome
<p>Lynch Syndrome (LS) is the most common inherited colorectal cancer (CRC) syndrome. It constitutes the perfect model to understand DNA mismatch repair deficient (MMRd) carcinogenesis, which underlies 15% of early-stage CRC. LS patients develop MMRd tumors with high loads of shared neoantigens …
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Impact of Intratumor Heterogeneity and The Tumor Microenvironment In Shaping Tumor Evolution and Response to Therapy
<p>Intratumor heterogeneity (ITH) is a crucial challenge in cancer treatment. The genotypic and phenotypic heterogeneity underlying diverse cancer types leads to subclonal variation, which may result in mixed or failed response to therapy. The heterogeneity at the tumor level, along with the tumor …