Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 260 for “"Immunogenicity"”.
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Human insulin: efficacy and immunogenicity
Contains fulltext : mmubn000001_028817273.pdf (Publisher’s version ) (Open Access)
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The Immunogenicity of Cholangiocyte Cellular Therapies
… essential component of that is an evaluation of immunogenicity. In this dissertation I investigated the immunogenicity of cholangiocyte organoids (COs) from an established system developed within the Vallier lab. I first assessed the survival of COs in vivo and generate CO lines expressing …
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Evaluation Of Immunogenicity Of Transgenic Chloroplast Derived Protect
Anthrax, a fatal bacterial infection is caused by Bacillus anthracis, a gram-positive, spore forming, capsulated, rod shaped organism. Centers for Disease Control (CDC) lists anthrax as Category A biological agent due to its severity of impact on human health, high mortality rate, acuteness of the …
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Sterility and immunogenicity of gamma-irradiated respiratory viruses
Gamma (γ)-radiation is a method commonly applied to sterilise pathogens in the biomedical, food and pharmaceutical industries. γ-radiation inactivates pathogens by causing irreparable damage to genomes to prevent replication. However, proteins and other antigenic structures are left mostly intact. …
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Studies on the Immunogenicity of Ascaris Suum Larval Antigens
Made available in DSpace on 2014-12-12T01:27:34Z (GMT). No. of bitstreams: 1 7212185.pdf: 3991155 bytes, checksum: 782ce1f25c9b4d0fd450537c66d031f3 (MD5) Previous issue date: 1971
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Engineering Nanoparticulate Antigens for Enhanced Follicular Accumulation and Immunogenicity
… that displayed an unusually high degree of immunogenicity. We found that these nanoparticles accumulated selectively within the follicular dendritic cell network of draining lymph nodes, and discovered that this trafficking pattern was dependent on complement recognition mediated by …
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The effect of manipulating apoptotic cell uptake on their immunogenicity
Failure of the immune system to differentiate between apoptotic tumour cells and cells rendered apoptotic as part of homeostasis prevents a successful response being mounted against tumours. Apoptotic cells are cleared rapidly by professional phagocytes thus preventing the release of potentially …
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INTERNALIZATION AND IMMUNOGENICITY OF MUCOSALLY-ADMINISTERED SOLUBLE AND PARTICULATE ANTIGENS
… antigen uptake at the mucosal surfaces, lack of immunogenicity of vaccine formulations, and the need for a better understanding of mucosal immune responses. In order to elicit an immune response, mucosal antigens must traverse the epithelium and reach the sub-epithelial immune compartments. …
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Immunogenicity and toxicity of yellow fever vaccines : a systematic review
… a possible outcome. OBJECTIVES To estimate the immunogenicity and toxicity of 17D and 17DD YF vaccines by summarizing the available data from randomised controlled trials. STUDY DESIGN A summary of randomized controlled trials (RCT) of YF vaccine immunogenicity and safety and tolerability was …
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Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines
Human papillomavirus (HPV) infection, specifically with oncogenic types, has been implicated in effectively all cervical cancer cases. Cervical cancer is a global health burden, especially in the developing world. Up to 18 types of HPV are considered oncogenic, of which HPV -16 and -18 cause 70% of …
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Tumor Antigens Revealed by Exome Seqeuncing Drive Editing of Tumor Immunogenicity
… extrinsic tumor suppressor, but also shape tumor immunogenicity. These observations led to the development of the cancer immunoediting hypothesis that stresses the dual host-protective and tumor-sculpting actions of immunity on developing cancers. We previously demonstrated important roles for …
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Identification, quantitation and immunogenicity of culture-derived soluble Babesia bigemina antigens
Soluble Babesia bigemina antigens were prepared from short-term in vitro cultures utilizing a microaerophilous stationary phase culture system. In two pilot immunization experiments involving 6 cattle, 3 doses of 25 ml-equivalent (838 EIA units) and 2 doses of 10 ml-equivalent (529 EIA units), …
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Controlled release microneedle technologies for the enhanced immunogenicity of subunit vaccines
The poor efficacy of subunit protein vaccines, which typically consist of a protein antigen and a molecular adjuvant, has recently been improved by completing multiple injections of the vaccine with an exponential dosing profile over time. The hypothesis is that as viruses replicate in a host …
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SARS-CoV-2 Variants of Concern: Biological Implications of Immunogenicity and Comorbidity
<p>When coronavirus disease 2019 (COVID-19) emerged in human populations in late 2019, there was nothing known about the virus, SARS-CoV-2, besides that it had a high degree of similarity to severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus …
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The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia
… there are currently no studies exploring the immunogenicity of the fusion positive AMKL cells and immunotherapeutic approaches are lacking. To address these knowledge gaps, I developed two mouse models to study transcriptional regulation by the CBFA2T3-GLIS2 fusion oncogene and the ability of …
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The Relationship of Structure and Immunogenicity of the Bee-Venom Peptide Melittin
… to understand the relationship of structure and immunogenicity of melittin and melittin analogs. From this analysis, a hypothesis for melittin's in vivo immunogenic structure predicated on binding to cell membranes or other lipophilic environments is suggested. Immunogenicity for antibody …
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Immunogenicity and Quantitation of Soluble Anaplasma Marginale Antigens From Cell Cultures and Blood
Short-term Anaplasma marginale cultures were initiated utilizing infected bovine blood from a splenectomized calf at various periods during acute parasitaemia employing Medium 199 supplemented with 10% adult bovine serum and 25 mM HEPES buffer. Better growth was observed in cultures initiated with …
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Purification, immunogenicity and protective potency of the F1 antigen from <i>Yersinia pestis</i>
<i>Yersinia pestis</i>, an organism endemic in much of the world, is the causative agent of pneumonic and bubonic plague. The disease is severe with a high mortality rate. Most plague vaccines are formalised whole cells, which give limited and short-lived immunity. An acellular vaccine could prove …
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The Immunogenicity of Plant-produced Human Papillomavirus (HPV) Virus-like particles (VLPs) in Mice
… VLP vaccine was used as a positive control. The immunogenicity of the vaccines was evaluated by testing for the presence of anti-L1 antibodies in sera from immunized mice using enzyme-linked immunosorbent assays (ELISAs) and western blots. Sera from immunized mice were also tested for the …
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