Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Immunogenic Proteins"”.
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… outer membrane and secreted Burkholderia proteins. These proteins were ranked according to predicted immunogenicity, and top vaccine candidates were selected based on the number and affinity of Major Histocompatibility Complex (MHC) epitopes. To confirm the in silico immunogenicity …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… outer membrane and secreted Burkholderia proteins. These proteins were ranked according to predicted immunogenicity, and top vaccine candidates were selected based on the number and affinity of Major Histocompatibility Complex (MHC) epitopes. To confirm the in silico immunogenicity …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… alone or in a combination containing various proteins in a clinically relevant and highly controlled aerosol murine model of infection. We have demonstrated that several glycoconjugates offer protection against lethality when delivered intranasally, with increased protection afforded by a …
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Development of a mucosal vaccine delivery system
… immunogens incuding non-pathogenic peptides and immunogenic proteins originating from pathogenic organisms. In particular, the reproductive self-hormone gonadotrophin releasing hormone (GnRH) conjugated with different carrier proteins was used as an immunogen in in vivo studies. Various mucosal …
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The identification of prostate cancer associated tumour antigens and biomarkers
… combines the separation of tumour proteins by conventional proteomic methods (2-DE and mass spectrometry) with serological screening using serum antibodies, to identify immunogenic proteins in cancer. This project aims to identify TAAs and/or biomarkers for PCa which on subsequent …
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DEVELOPMENT OF A SUBUNIT LAWSONIA INTRACELLULARIS VACCINE
… disease and improve swine health. Previously, LI proteins targeted by antibodies from vaccinated rabbits were identified and suggested to be appropriate for inclusion in an LI subunit vaccine. Work commenced by further evaluating the immunogenicity of LI proteins when formulated in multivalent …
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Creating a Marked Mycobacterium avium subsp. paratuberculosis Vaccine Strain and Detecting Marker-Specific Immune Responses in Calves
… were used to replace a gene coding for an immunogenic protein (MAP1693c) in the MAP genome with an HA (human influenza hemagglutinin) epitope-tagged immunogenic gene (PepA) via allelic exchange. Once gene replacement was confirmed, these markers were evaluated in a calf infection trial, …
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Identifying Merozoite Targets of Protective Immunity Against <i>Plasmodium falciparum</i> Malaria
… First, to identify merozoite antigens that were immunogenic, I resolved proteins extracted from <i>P. falciparum</i> merozoites by two-dimensional gel electrophoresis and tested these for reactivity with immunoglobulins from malaria immune adults. Immunoreactive proteins were then identified by …
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An Analysis of the Role of Bacillus oleronius Proteins in the Pathogenesis of Ocular Rosacea
… established that B. oleronius produces two immunogenic proteins that are capable of inducing an immune response in rosacea patients. As part of this project, the serologically reactive proteins were isolated and purified by anion exchange chromatography and ÄKTA FPLC™ for their use in …
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Comparison of the two lumpy skin disease virus vaccines, Neethling and Herbivac, and construction of a recombinant Herbivac-Rift Valley fever virus vaccine
… construct a recombinant Herbivac which expresses immunogenic proteins of Rift Valley fever virus (Herbivac-RVFV). Herbivac-RVFV was designed to express specific RVFV genes selected for their antigenic properties. The genes selected are also representative of the genes from recent viral outbreaks …
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Identifikation und Charakterisierung neuer immunogener Proteine und anschließende Generierung rekombinanter Antikörper mittels Phage Display
… Membrantopologie oder unspezifischen Proteinsequenz wurden scFv-Antikörper gegen acht Proteine mittels Phage Display generiert und anschließend als scFv-Fc-Fusionsantikörper produziert und charakterisiert. Die hier identifizierten Proteine und linearen Epitope könnten einen Ansatzpunkt …