Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 248 for “"Immunogenic"”.
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Exploring the tumor microenvironment of immunogenic cancers
Contains fulltext : 302594.pdf (Publisher’s version ) (Open Access)
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Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines
Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical cancer burden. Current HPV L1 major capsid protein virus-like particle (VLP)-based vaccines are effective in the …
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Engineering minimally immunogenic cargos and delivery modalities for gene therapy
… the potential for off-target effects, and the immunogenicity of the CRISPR-Cas9 system. One of the main challenges of gene therapies is the immunogenicity of the (1) therapeutic vector and (2) cargo. Existing delivery systems trigger immune responses, rendering therapies ineffective and pose …
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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
<p>Unprecedented durable tumor regression can be achieved in patients with checkpoint blockade immunotherapy, yet these responses are rare and are not observed in all tumor types. Castration resistant prostate cancer (CRPC) and pancreatic adenocarcinoma (PDAC) are two common lethal cancers that …
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Development and characterization of immunogenic genetically engineered mouse models of pancreatic cancer
… we have characterized two preclinical models of immunogenic pancreatic ductal adenocarcinoma (PDAC). In order to dissect the endogenous antigen-specific T cell response in PDAC, lentivirus encoding the Cre recombinase and a tumor specific antigen (SIINFEKL, OVA[subscript 257-264]) was delivered …
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
… chemo-photothermal therapy (PTT) to induce immunogenic cell death (ICD) and target the medication to the tumor site. ICD overall causes the activation of dendritic cells (DC) and T cells to initiate an antitumor immune response and is characterized by the presentation of damage associated …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
… of OVs is attributed to their ability to induce immunogenic cell death (ICD) during their infection of tumour cells. The mechanisms by which ICD occurs is not well defined and while OVs show immunotherapeutic promise, greater understanding of how specific viruses achieve ICD is needed to allow …
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Identification of candidate tumour antigen peptides with immunogenic potential for use in cancer immunotherapy
… MHC class II HLA-DR1 and HLA-DR4 restricted immunogenic peptides derived from the MART-1 and Tyrosinase tumour antigens. A computer algorithm (SYFPEITHI; available on the World Wide Web) was used to predict immunogenic peptides from the two tumour antigens; these peptides were then used to …
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A Signal to Divide: Apoptotic Extracellular Vesicles as Carriers of Mitogenic and Immunogenic Signals
… factor (MIF), stimulating both proliferative and immunogenic effects on recipient cells. MIF on esAEVs promote compensatory proliferation of epithelial stem cells and influence macrophage surveillance. Interestingly, <em>mif</em> is highly expressed in epithelial stem cells, whereas its cognate …
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Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines
… pipeline for identifying and validating immunogenic neoantigens from chimeric RNAs, with promising implications for personalized cancer vaccines. The CD74-NRG1 fusion, resulting from a translocation between chromosomes 5 and 8, creates a unique fusion junction that disrupts cell signaling …
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The titration of an immunogenic agent against Leptospira pomona using Syrian golden hamsters (Cricetus auratus)
… the system of the test animal or a condition of ”immunogenic paralysis“ results. Due to the number of hamsters in any one group whose pooled sera was tested, a fair evaluation could not be made between various groups in the agglutination-lysis test. Tests on the stability of the immunogenic agent …
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Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… prioritization, and validation of immunogenic neoantigens derived from chimeric RNAs. The FGFR3-TACC3 fusion, generated through an intrachromosomal rearrangement on chromosome 4, produces a unique junctional sequence that constitutively activates oncogenic signaling while remaining …
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Discovery of Immunogenic Neopeptides from Chimeric RNAs to Develop Peptide and mRNA Vaccines for Lung Cancer Treatment
… toward the binding pocket of HLA-C*07:02. The immunogenicity of these neoantigenic peptides to HLA-C*07:02 matched Peripheral Blood Mononuclear Cells (PBMCs) was assessed by the IFN-γ Enzyme Linked Immunosorbent Spot (ELISpot) assay. Effects across donors were identified, as PBMC-isolated CD8+ …
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Immunogenic Properties of Purified Antigens Isolated From the Serum of Horses, Dogs and Rats With Acute Babesiosis
Made available in DSpace on 2014-12-09T22:30:11Z (GMT). No. of bitstreams: 1 6612423.pdf: 3865384 bytes, checksum: a6e33b8ffe5dda161b2d0a4f5c4f1213 (MD5) Previous issue date: 1966
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Production, characterization and evaluation of the chemotherapeutic and immunogenic potential of protein based virus-like particles in tumoral and immune cell lines
In this thesis, nanotechnology was used to develop three inedited platforms with clinical applications. Results are presented in three chapters written in article format. In the first chapter, in vitro assays are used to characterize a new doxorubicin (DOX) carrier virus-like platform and to …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… by a refined formulating containing the most immunogenic proteins. Also, we have shown that antigen-specific humoral responses play a significant role in the protection induced by various AuNP-coupled glycoconjugate formulations. Similarly, we have shown a protective effect of AuNP-coupled …
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Assessing TMV as an immunogenic particle : the expression of HIV-1 subtype C V3 loop neutralizing antibody epitopes on the surface of TMV virions
… and enzyme-linked immunosorbent assays. Immunogenicity analysis using a guinea pig model was used to assess the ability of the recombinant vectors to firstly establish a V3-specific immune response, and secondly to stimulate a virus-specific neutralization antibody response. As a result …
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Immunogenic assessment of plant-produced Human papillomavirus type 16 chimaeric L1:L2 virus-like particles and the production of an encapsidated therapeutic DNA vaccine candidate
… cross-neutralising antibodies. To increase the immunogenicity of L2, second-generation L1:L2 chimaeric VLP (cVLP) vaccines have been investigated. In this study, the 4 L2 peptides above were used to generate plant-produced HPV-16-derived L1:L2 chimaeras. The L2 epitopes were substituted into the …
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