Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Immunogenetics"”.
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TRANSPLANTATION IMMUNOGENETICS OF THE CANINE TRANSMISSIBLE VENEREAL TUMOR.
TRANSPLANTATION IMMUNOGENETICS OF THE CANINE TRANSMISSIBLE VENEREAL TUMOR.
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Immunogenetics of free-ranging felids on Namibian farmlands
Genetic variation is crucial for the long-term survival of the species as it provides the potential for adaptive responses to environmental changes such as emerging diseases. The Major Histocompatibility Complex (MHC) is a gene family that plays a central role in the vertebrate’s immune system by …
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A Study of the Molecular Immunogenetics of Type 1 Diabetes in Man
Type 1 diabetes is caused by immune destruction of pancreatic β cells. There is increasing evidence that genes outside the MHC region contribute to the pathogenesis of type 1 diabetes. Cytokines due to their role in immune regulation seem to play a crucial role in the pathogenesis of the disease. …
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Conservation and population genetics of African and Asian rhinoceros
There are five living species of rhinoceros inhabiting Africa and Asia: black rhinoceros (Diceros bicornis), white rhinoceros (Ceratotherium simum), Indian rhinoceros (Rhinoceros unicornis), Javan rhinoceros (Rhinoceros sondaicus) and Sumatran rhinoceros (Dicerorhinus sumatrensis). Anthropogenic …
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Immunogenicity of Staphylococcus Aureus Antigens Against Experimentally Induced Mastitis in the Mouse and Optimization of Antigen Production in Fermenter Culture
Capsular antigens of "Staphylococcus aureus" Smith and 2-8 strains were evaluated for immunogenicity in mice. Cultural conditions necessary for maximum expression of the antigens were also defined. Actively growing "S. aureus" Smith strain culture was used to challenge lactating GF-1 strain mice …
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Immunogenetic Study of Autoimmunity-Associated Variants in Selected TNF Superfamily Genes
Major advances in human genetics have paved the way for the development of Genome Wide Association Studies (GWAS) in an effort to understand complex traits - including autoimmune diseases such as Multiple Sclerosis (MS). Using unbiased genome screens of affected individuals and appropriately …
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Variation at Major Histocompatibility Complex Class I Loci In Two Killifish Species with Reduced Genetic Variance
The ability of natural selection to promote and preserve genetic variation at Major Histocompatibility Complex (MHC) class I loci was examined in two fish species known to have low genetic variation either as a consequence of their breeding system or population structure. The tempo and modes of …
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Cellular immune mechanisms of psychiatric disorders and the stress response
Multiple psychiatric disorders have been associated with abnormalities in the immune system. As I summarise in my opening chapter (Chapter 1), evidence from human and animal studies suggests that the immune system may be implicated in the pathogenesis of these disorders, at least in a subset of …
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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
<p>Heterogeneity in the human immune system can lead to limited vaccine efficacy, poor response to therapeutics, increased susceptibility to immune mediated diseases, and differential outcome to infection. Studies to date have suggested a role for biological, environmental, and genetic factors in …
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Development of An In Silico Kir Genotyping Algorithm and Its Application to Population and Cancer Immunogenetic Analyses
<p>Gene content determination and variant calling in the complex KIR genomic region are useful for immune system function analysis, pathogenesis and disease risk factor elucidation, immunotherapy development, evolutionary investigations, and human migration modeling. Sequence-specific …
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Systems Biology Approach to Identifying Host Interactive Pathways Modulating the Severity of Streptococcal Sepsis
<p>Clinical outcomes of infectious diseases are controlled by complex interactions between the host and the pathogen. Epidemiological, genetic and molecular studies in my mentor’s laboratory provided evidence that in invasive Group A streptococcal (GAS) infections, genetic variations in both …