Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Immunoediting"”.
-
Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
Immunoediting describes the process in tumour development whereby tumours evolve to avoid the immune system. The relevance of immunoediting in carcinogenesis, metastasis and immunotherapy resistance makes understanding the mechanisms of immunoediting essential in informing cancer therapy and …
-
Tumor Antigens Revealed by Exome Seqeuncing Drive Editing of Tumor Immunogenicity
… led to the development of the cancer immunoediting hypothesis that stresses the dual host-protective and tumor-sculpting actions of immunity on developing cancers. We previously demonstrated important roles for lymphocytes and type I: IFN-α/β) and type II: IFN-γ) interferons in cancer …
-
Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… variants in a Darwinian process termed cancer immunoediting, or by the recruitment of immune suppressive cells to the tumour microenvironment. This distinction is important as it informs the best means of cancer immunotherapy. Our lab has previously demonstrated that a stromal cell marked by …
-
Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
… than prevention. Tumor immune surveillance and immunoediting have largely been defined using carcinogen-driven models of sarcomagenesis. Using a genetically engineered model of sarcomagenesis, I show that immunoediting requires potent T cell antigens and that lymphocytes drive the evolution of …
-
Mathematical Modelling of the Immune Response to Cancer
… review article - “The Three Es of Cancer Immunoediting” - discusses the way the immune system interacts with cancer cells: elimination, equilibrium, and escape. This bio- logical explanation underpins the mathematical modelling in this PhD thesis where mathematical models of pre-angiogenic …
-
The role of idiotype-specific immunity in antigen receptor diversity
… HLA alleles tested suggesting that there is no immunoediting of the T cell repertoire. Simultaneously, this study attempts to determine the processing and presentation of CDR3-derived peptides at the cell surface using lymphocyte antigen receptor models containing CDR3-encoded viral epitopes. …
-
Integrative genomic approaches to dissecting host-tumor and host-pathogen immune processes
… Our genetic findings thus provide evidence for immunoediting in tumors and uncover mechanisms of tumor-intrinsic resistance to cytolytic activity. Second, we combined measurements of protein production and degradation and mRNA dynamics so as to build a quantitative genomic model of the …
-
Subclonal Evolution of Chronic Lymphocytic Leukemia After Allogeneic T Cell Therapies
… evolution was coincident with DLI, suggesting immunoediting of leukemic subclones. To investigate complementary changes in immunity, we analyzed the post-alloSCT T cell repertoires of CLL transplant recipients at multiple time points after engraftment and observed restricted diversity. Last, we …
-
The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… be involved in controlling immunogenicity and immunoediting of breast cancer cells. To investigate the interaction of CD74 with CD44 and MIF, confocal microscopy and co-immunoprecipitation techniques were used. The three molecules form a multimeric complex in cytoplasmic compartments as …
-
Development of an IL12 Prodrug to Treat Solid Tumors with Minimal Toxicity
… immunity plays a critical role in cancer immunoediting, allowing CTLs to recognize and kill aberrant cells. Because of this, IL12 has been tested in many different preclinical and clinical studies for its potential use as an anti-tumor therapeutic agent. However, IL12 also causes severe, …
-
Characterisation of the Tumour Microenvironment in Ovarian Cancer
… the T cell chemoattractant CXCL9 and evidence of immunoediting. These findings suggest that multiple distinct tumour immune microenvironments can co-exist within a single individual and may explain in part the hetero- geneous fates of metastatic lesions often observed in the clinic post-therapy. …
-
Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression during Immunotherapy
<p>Tumors are dynamic ecosystems that evolve under selective pressures, shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral …
-
Characterizing the role of Nucleosome Remodeling Factor (NURF) in tumorigenesis and metastatic progression using mouse models of breast cancer.
Increasingly the role of epigenetic machinery as a bridge between underlying DNA sequence and cellular phenotype is being discovered. The establishment of a myriad of unique cellular types sharing identical gene sequences in a multicellular organism gives a broad sense for the inherent role of …