Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Immunodominant Epitopes"”.
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Computational Study of Vaccination Strategies to Change B Cell Immunodominance
… the phenomenon where B cells that target certain epitopes of a pathogen are preferentially selected among the B cells that potentially target diverse epitopes presented on a pathogenic protein. This phenomenon presents a challenge in the development of vaccines against mutable viruses like HIV, …
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Candidate Bivalent HCV Vaccine: A Novel Approach To Vaccine Design for Hyper-variable Viruses
… it has been proposed that highly variable, immunodominant epitopes should be amputated from HCV vaccine antigens to avoid induction of strain-specific antibodies, as a proof-of-concept our approach was used to develop a bivalent HCV vaccine explicitly designed to elicit AB to HVR1 …
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Immunological and Molecular Analyses of the Borrelia burgdorferi OspF Protein Family F
… of OspF proteins during infection and mapped the immunodominant epitopes which lie within the variable domains. To determine if OspF-related proteins are produced by other isolates, immunoblot analyses were performed using sera collected from mice and humans infected with diverse B. burgdorferi …
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A Novel Platform to Generate Synthetic Vaccine Candidates
… immune response by undergoing rapid mutations in immunodominant epitopes [4-6]. In addition, although they usually express conserved epitopes that are important for inducing neutralizing antibodies, in many cases these are not immunodominant. Traditional techniques in vaccine development have not …
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Phylogeny of the Genus Arachis and its Application to the Evolution of the Major Peanut Allergen Ara h 2
… those from other sections had shorter loops. The immunodominant epitopes #6 and #7, located within this loop, tended to contain mutations or were truncated among species outside of section <i>Arachis</i>. Dot immunoblots showed reduced IgE-binding to peptides representing portions of the H2-H3 …