Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Immunoconjugate"”.
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Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy
… 3rd generation photosensitisers include photoimmunoconjugates.Three synthetic routes were developed, with the aim of producing novel bioconjugatable porphyrins, which could be subsequently conjugated to cysteine residues expressed by a suitable monoclonal antibody (SIP(L19)). Two cationic, …
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… to explore the therapeutic efficacy of this immunoconjugate as well using the <sup>177</sup>Lu labeled derivative, [<sup>177</sup>Lu]Lu-DTPA-A”-CHX-aCD133. As for radioimmunotherapy, we describe creating a HER2-targeting nanobody with a residualizing prosthetic group for radiohalogenation to …
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Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology
… targeting antibody, we developed a recombinant immunoconjugate able to carry BG-modified photosensitizers to selectively target and eliminate malignant melanoma cells. Conjugation of the SNAP-tag fusion protein with the fluorescent dye Alex Fluor 488 showed that anti-CSPG4-SNAP binds …
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
… to cancer cells. Site-specifically modified radioimmunoconjugates exhibit superior <em>in vitro</em> and <em>in vivo</em> behavior compared to analogues synthesized <em>via</em> traditional stochastic methods. However, the development of approaches to site-specific bioconjugation that combine high …
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T-Zell-priming außerhalb sekundärer lymphatischer Gewebe
T-Zellimmunantworten werden normalerweise durch folgenden Weg initiiert: unreife dendritische Zellen nehmen Antigen in der Peripherie auf, wandern in die sekundären lymphatischen Organe, wobei sie auf ihrem Weg sowohl reifen als auch das Antigen prozessieren. In den sekundären lymphatischen Organen …