Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 221 for “"Immunocompromised"”.
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Cytomegalovirus viraemia in immunocompromised children in Cape Town
Includes bibliographical references (leaves 54-62).
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Invasive fungal disease in immunocompromised hosts with focus on diagnostics
… diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD in different groups of immunocompromised patients. Papers I and II included patients with hematologic disorders. Paper I was a …
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Investigation of antifungal compounds against Aspergillus species from respiratory infections of immunocompromised patients
Submitted in fulfilment of the requirement for the Degree of Doctorate of Philosophy in Biotechnology, Durban University of Technology, Durban, South Africa, 2023.
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Aspects of orthopaedic surgical research with emphasis on surgery in haemophilia and immunocompromised patients
<b><i>Some internet browsers may have problems loading this document. If so, please save the file to your device and open it with Adobe Acrobat, or another PDF reader.</i></b><br/><br/>Ninety-three publications have been presented from the last 22 years.This body of work represents an opus of …
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The relative importance of human and animal sources of vancomycin-resistant Enterococcus faecium in immunocompromised patients in hospital
… infection, disproportionally affecting immunocompromised and critically ill patients. Despite infection control measures, rates of vancomycin-resistant E. faecium (VREfm) bacteraemias have failed to decline in the United Kingdom, and Cambridge University Hospitals (CUH) report the …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
<p>Retrospective data analysis suggests that inflammatory breast cancer (IBC) patients who take statins have better locoregional control after radiotherapy than those who do not [23]. Our lab has previously demonstrated that simvastatin radiosensitizes IBC cells in vitro [23], and brain metastases …
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The Virome in Primary and Secondary Immunodeficiency
The afflictions suffered by immunocompromised individuals have historically been attributed to overt infections caused by bacterial and fungal pathogens. For this reason, treatment methods have focused on resolving these infections, with great success in terms of reducing short-term morbidity and …
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Using single nucleus RNA-seq to determine the effect of immunosuppression on the transcriptional activity of resident CNS cells in a mouse model of CNS-TB
… many transcriptional studies have examined the immunocompromised response to CNS-TB, but none have done so atsingle cell resolution. Single nucleus RNA Sequencing (snRNA-seq) was used to determine the effect of immunosuppression on the transcriptional activity of resident CNS cells in a mouse …
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SARS-COV-2 EVOLUTION AND TRANSMISSION: WITHIN-HOST, BETWEEN-HOST, AND BETWEEN-SPECIES
… investigate the evolution of SARS-CoV-2 within immunocompromised individuals with prolonged infections, compare viral adaptations between vaccinated and unvaccinated hosts, and explore interspecies transmission between humans and animals. We found that SARS-CoV-2 evolution rates are increased …
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The application of clinical metagenomics to central nervous system infections in a resource-limited setting
… pathogen was detected by CMS in 8 (38%, n=8/21) immunocompromised and 2 (9%, n=2/22) immunocompetent participants. The median cost of conventional CNS infectious disease investigations was £180,80 (IQR: £127,40-£281,40) in immunocompromised participants and £68,56 (IQR: £9,81-£127,40) in …
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Antioxidants Facilitate Recovery From Lipopolysaccharide Induced Sickness
… experience marginal nutrient deficiencies, are immunocompromised and highly susceptible to infections.
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Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
… that is of consequence to pregnant women and immunocompromised individuals. Exploiting a niche, <italic>Lm</italic> gains access to the host cell cytosol via the pore forming toxin listeriolysin O (LLO) and infects a variety of cell types including dendritic cells (DC). Our laboratory and …
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Development of protein microarrays for the investigation of host-pathogen interactions
… is particularly important in pregnancy and immunocompromised patients. Current sérodiagnostic assays are either based on crude whole cell lysates or glycoprotein preparations lacking high specificity and sensitivity. The work presented here investigates the humoral immune response to VZV …
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How Listeria monocytogenes crosses host cell barriers
… can cause severe complications and mortality in immunocompromised or pregnant people. Listeria is able to cross several host barriers to cause severe disease, including the intestinal barrier, the blood-brain barrier, and the placental barrier. This is mediated by a diverse range of bacterial …
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An Analysis of the Response of Aspergillus fumigatus and Candida albicans to Caspofungin
… is capable of causing a range of diseases in immunocompromised patients and is responsible for up to 3% of all hospitalbased deaths in the EU. The yeast Candida albicans induces a range of diseases in immunocompromised patients. Caspofungin is a recently introduced antifungal compound that has …
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Role of growth hormone and prolactin in regulating T-dependent immune responses and macrophage activation in aged rats
… and they also augment immune responses in immunocompromised and aged individuals. We previously showed that GH and PRL treatment of aged rats resulted in fully regenerated thymus glands and enhancement of certain T cell-mediated responses. The studies described here utilized primarily the …
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Factors Governing Gastrointestinal Colonization of Candida albicans
… tract (GI) and cause disseminated infections in immunocompromised hosts. Depletion of specific gut commensal microbiota is associated with or results in increased C. albicans burden in the gut and increased likelihood of dissemination in human patients and mice, respectively. The exact mechanisms …
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Cryptococcus neoformans e Cryptococcus gattii: quimiotipagem e correlação com criptococose em hospitais públicos de João Pessoa - PB.
… and clinical parameters in immunocompetent or immunocompromised , with clinical suspicion of cryptococcosis, assisted in hospitals in João Pessoa - PB from 1998 to 2012. The data were collected through medical records, epidemiological and medical records, as the case definition was established …
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Functional Genomic Analysis of Natural Product Biosynthesis and Secretion in Aspergillus fumigatus
… pathogen which can cause severe disease in immunocompromised patients. A. fumigatus produces metabolites, through a non-ribosomal peptide synthesis mechanism, including iron-chelating molecules known as siderophores and other unusual compounds such as gliotoxin. These provide the fungus with …
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