Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"Immunobiology"”.
-
ROLE OF THE GRAFT TISSUE IN THE IMMUNOBIOLOGY OF ALLOGENEIC TRANSPLANTATION.
ROLE OF THE GRAFT TISSUE IN THE IMMUNOBIOLOGY OF ALLOGENEIC TRANSPLANTATION.
-
Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
This study investigated the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the …
-
Rare event simulation for probabilistic models of T-cell activation
One of the central questions in immunobiology is: How does the immune system reliably distinguish between antigens of our own body and foreign antigens? This ability is critical for our survival. One of the major cell types involved in these decisions are the so called T-cells, which are …
-
HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
… network that links liver and tumor immunobiology wherein hepatocytes govern productive T cell surveillance in cancer and favorable responses to cancer therapies.
-
Quantifying the Effect of Vitamin D Deficiency and Alcohol Exposure on Immune Response to Mycobacterium Infection
The goal of the May Multiscale Immunobiology Design, Algorithms, & Simulation (MIDAS) Lab is to develop dynamic empirical and simulation-based models of host-pathogen interactions to further our understanding of the mechanisms guiding immunologic response. Previous studies on the role of vitamin D3 …
-
The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
… remarkable progress in our understanding of the immunobiology of CLL, the aetiology of the disease remains unknown. The consensus is that CLL cells are driven by (auto)antigen(s) through the B cell receptor (BCR) and are regulated by a variety of signals received from the microenvironment, …
-
Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… ccRCC, focusing on both tumour proliferation and immunobiology. To resolve ccRCC ex vivo expansion, I used transcriptomic and proteomic identification of proliferative-niche factors and I developed a serum-free, multi-parameter, high throughput organoid formation assay to evaluate candidates for …
-
UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
… mechanisms at the base of SC plasticity, and the immunobiology of SCH, giving further proof of the potential impact of EMFs on peripheral glial cells. Our study highlights the molecular pathways and microenvironmental interactions that may contribute to VS initiation and progression, offering a …
-
Molecular Mechanisms of HIV-1 Infection: Viral and Host Determinants in Transmission and Pathogenesis
HIV-1 vertical transmission is the predominant cause of AIDS in children. In addition, HIV-1 infected infants have a higher viral load and progress to AIDS more rapidly than infected adults. However, the molecular mechanisms of HIV-1 vertical transmission and pathogenesis are not known. Work …
-
Investigating The Distinct Role of Pd-L2 In Modulating Human T Cells Responses
… guided by a comprehensive understanding of the immunobiology underlying PD-1 signaling. However, the highest affinity ligand of PD-1, PD-L2 remains understudied and has yet to be directly interrogated for therapeutic potential. Recent reports have begun to reveal the relevance of PD-L2 in tumor …
-
Immune responses to AAV gene therapy in the ocular compartment
… novel aspects of phosphodegron mutant AAV2 immunobiology and identified a possible utility for the administration of prednisolone as a tool for enabling repeated gene transfer of AAV gene therapy vectors.
-
Studies on the Interaction between Porcine Plasmacytoid Dendritic Cells and Porcine Reproductive and Respiratory Syndrome Virus
… agonist, type A CpG ODN (ODN19). In terms of immunobiology, probably the most important discovery was that in general PRRSV not only did not elicit an IFN-a response from PDC, but, actually impeded the typical induction of IFN-a expression by TGEV- or ODNl 9- stimulated PDC. Confirming that …
-
Reagents and Tools to Identify Epizootic Hemorrhagic Disease Virus-2
<p>The purpose of this project was to define monoclonal antibodies against viral proteins from Epizootic Hemorrhagic Disease Virus (EHDV) to be used in quality control of vaccines produced by an industrial partner, and development of tools to identify EHDV. EHDV is an Orbivirus, which also includes …
-
Characterization of Shiga-toxin Producing Escherichia coli Infections and Cryptosporidiosis in South Dakota with Respect to Animal Exposures, 2012
<p>Shiga-toxin producing strains of <em>Escherichia coli</em> (STEC) and <em>Cryptosporidium</em> spp. are significant causes of illness in humans. Incidence rates of these illnesses are higher in South Dakota than in the United States as a whole. Transmission of these agents to people through …
-
Using Genetic and Pathogeneses Studies to Develop Antiviral and BVDV Vaccine Targets
<p>Understanding bovine viral diarrhea virus (BVDV) interaction with the host may help explain the ability of the virus to cause multiple forms of disease ranging from subclinical symptoms to severe disease and even death. BVDV cytopathogenicity and onset of mucosal disease within one herd of PI …
-
Influenza Viral Protein Interaction Detecting Methods Development and A.M1-host Interplay Network Investigation
<p>The viral RNA-dependent RNA polymerases of influenza A and B are trimetric complexes (PA, PB1, and PB2 subunits), and are crucial for both transcription and replication of the viral genome. While there are extensive data on the structure and function of influenza A polymerase, the influenza B …
-
Molecular Diagnosis and Anthelmintic Control of Trichostrongyle and Toxicara nematodes in Bison bison Herds from the U.S.A. Central Great Plains
<p>Bison producers face many challenges, including the transmission of parasitic diseases such as trichostrongylosis and toxocariasis into and within their herds. These diseases can reduce animal production and cause occasional death. There have been no surveys to identify gastrointestinal …
Page 1 of 2