Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Immuno-oncology"”.
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Mathematical Modelling of Immuno-Oncology and Related Immunology
<p>Immunotherapy offers new and promising treatments for many different types of cancer, but the problem of how to practically regulate the immune response in a way that allows it to fight cancer without overwhelming patients with potentially fatal inflammatory toxicity has yet to be solved. This …
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Design, synthesis, and preliminary biological evaluation of novel small molecules modulating the HuR RNA-binding protein and other therapeutically relevant targets in immuno-oncology.
… responses against cancer cells (i.e., cancer immunotherapy). Both TF-targeted and immuno-stimulating agents are used as stand-alone or in combination, depending on the tumor microenvironment (TME), on genetic and epigenetic modifications of cancer cells, on the patient’s health and on many …
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
… key resistance-associated programs, including immunosuppressive cytokine signaling, metabolic signaling, and neuroactive pathways such as calcium and cAMP signaling. Unsupervised clustering identifies three tumor subtypes—responder-dominant, non-responder-dominant, and an intermediate …
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… and may influence response to emerging immunotherapies. Using quantitative immunohistochemistry, we found increased densities of effector T cells and increased expression of several checkpoints (including PD-L1) at the center of PI3K-altered early-stage MSS CRC. Subgroup analysis showed …
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Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
… of size-based criteria in targeted and immuno-oncology treatment is well-documented. Three clinical trials investigated morphological and physiological 1H-MRI to detect early response and predict outcome. Multiparametric MRI demonstrated physiological changes after 12 days of …
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Modelling pancreatic cancer in vivo with patient derived organoids & humanised mouse models for the investigation of immunotherapeutic treatment response
… The complex genomic, microenvironmental and immunophenotypic heterogeneity of PDAC tumours presents as a major obstacle in the assessment and development of novel therapeutic interventions. Immunotherapies aim to treat cancer through the activation and enhancement of anti-tumour immunity and …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
Regulatory T cells are one of the integral components of the adaptive immune system that contribute to the regulation of anti-tumor T cell responses. However, studies have suggested that alterations in T cell signaling networks can result in T cells that are resistant to the suppressive effects of …