Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Immunity, Innate"”.
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Effect of HIV infection and pregnancy on parameters of vaginal immunity
… immune environment. Like with systemic immunity, innate and adaptive immune mediators are integrated in the efficiency for fighting infections in the female genital tract. Our study addresses the role of pregnancy and HIV infection on concentrations of cytokines in genital tract fluid …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… for the generation of effective protective immunity. Innate lymphoid cells and T cells play central roles in orchestrating bespoke immune reactions by producing specialised repertoires of immuno-regulatory cytokines. ILC2 and natural killer (NK) cells are generated in the bone marrow and …
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Liquid-Liquid Phase Separations in Innate Immune DNA Sensing and NF-κB Signaling Pathways
… cyclic GMP-AMP (cGAMP), which activates innate immune responses. We have shown that DNA binding to cGAS robustly induced the formation of liquidlike droplets in which cGAS was activated. The disordered and positively charged cGAS N terminus enhanced cGAS-DNA phase separation by increasing …
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Host Modulators of the Death Response to Influenza A Infection
Influenza A virus infects 5-20% of the population annually, resulting in ~35,000 deaths and significant morbidity. Current treatments include vaccines and drugs that target viral proteins. However, both of these approaches have limitations, as vaccines require yearly development and the rapid …
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The Ligand and Function of the RegIII Family of Bactericidal C-Type Lectins
… they can cause inflammation and sepsis. The innate immune system plays a crucial role in preventing bacterial incursions across gut epithelial surfaces. Mucosal epithelial cells produce a variety of secreted antimicrobial proteins that help to prevent bacterial attachment and encroachment at …
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Enhancement of the An1 Population by BAFF: Potential Role in Autoimmune Disease
The cytokine BAFF is a TNF family member found to be essential for the homeostasis of B cells. Numerous studies have shown BAFF to be involved in the pathogenesis of autoimmune diseases, including Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis. In an effort to understand the role of …
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Regulation of the cGAS-STING Pathway: Non-Agonist Activation and Cellular Trafficking
The cGAS-STING pathway in the innate immune system plays an important role in infection and cancer. Exogenous or endogenous DNA and cyclic dinucleotides acutely activate cGAS-STING, leading to type I interferon (IFN) signaling. STING-mediated IFN signaling is dynamically regulated by STING …
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Regulatory Mechanisms in Innate Immunity
Innate immunity is the frontline for the host to defend against infections. This process entails the cooperation among pathogen recognition receptors, adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 …
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Structural Basis for the Activation of RIG-I/MAVS Antiviral Immune Signaling
The file named "XU-DISSERTATION-2015.pdf" is the primary dissertation file. The supplemental file named "Movie 1.mp4" may be viewed individually.
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Targeting and Modeling Immune Resistance in Lung Cancer
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Molecular Mechanisms Underlying Innate Immune Kinase TBK1-Driven Oncogenic Transformation
An essential kinase in innate immune signaling, TBK1 couples pathogen surveillance to induction of host defense mechanisms. The pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive oncogenic stress. The mechanistic basis of TBK1 prosurvival …
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Regulation of the cGAS-STING Pathway in Health and Disease
Pages v-xiii are misnumbered as pages vi-xiv.
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
<p>There is a dynamic interplay between pathogens and their hosts. This interplay has resulted in a constant struggle where the host is attempting to clear the pathogen, while the pathogen attempts to subvert the host’s immune system. The result of the back and forth has resulted in what is called …
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Equine innate and adaptive immunity to viral infections
Activation of innate immunity through Toll-like receptor (TLR) signaling can also enhance antigen-specific adaptive immunity. TLR9 is an endosomal receptor for unmethylated bacterial and viral cytosine-phosphate-guanine DNA (CpG-DNA). West Nile virus (WNV) infection may result in meningitis and …
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Developing an in vitro model to study trained immunity
Novel discoveries have proven that the innate immune system has the capacity to adapt a memory response, termed “trained immunity”, providing broad non-specific protection against pathogens. To date, trained immunity has been studied in vivo, and ex vivo using human peripheral blood mononuclear …
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Inflammasome signalling during Salmonella Typhimurium infection
The innate immune system is the first line of defence against infection. It is comprised of physicochemical barriers and a variety of cell types including macrophages and dendritic cells. Pathogens express specific pathogen associated molecular patterns (PAMP) which are recognised by pattern …
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The role of the type-I interferon response in the aggregation of tau protein
… alongside prominent neuroinflammation. The innate immune response, the first line of defence against foreign pathogens, is emerging as a major contributor to the development of neurodegenerative disease. IFN-Is are soluble cytokines produced in the innate immune response which induce an …