Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Immune-mediated disease"”.
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Integrative statistical methods for the genomic analysis of immune-mediated disease
… loci influencing thousands of complex human disease phenotypes. However, elucidating the causal mechanisms underlying such associations has proved challenging due to the regulatory nature of the majority of signals. In Chapters 2 and 3, I hypothesised that promoter-capture Hi-C (PCHi-C) data …
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A study of a multi-systemic immune-mediated disease in the English Cocker Spaniel
Chronic pancreatitis (CP) is a common disease in the English Cocker Spaniel (ECS) and shows a distinctive clinical and histopathological appearance. It is characterised by duct destruction, interlobular fibrosis, dense periductular and perivenous lymphocytic aggregates, the presence of multi-organ …
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Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… strategies to regulate their host’s immune response, to prevent expulsion and establish chronic infections. Understanding how they achieve this offers a therapeutic strategy for the treatment of human diseases which are caused by unregulated inflammation. Previous characterisation of …
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Systems Immunology Approaches for Precision Medicine
The mucosal immune system encompasses a wide array of interactions that work in concert to protect an individual from harmful agents while retaining tolerance to molecules, microbes, and self-antigens that present no danger. The upheaval in the regulation-response balance is a critical aspect in …
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
… (TCDD) exposure can permanently alter immune system ontogeny, resulting in the dysregulation of a number of vital immune pathways. We hypothesized that developmental exposure to TCDD may also impair the establishment of self-tolerance, resulting in an increased risk of autoimmunity. For …
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Bacterial Kidney Disease and Its effect on the Salmonid Immune response
… the etiological agent of bacterial kidney disease (BKD) of salmonid fish, is a pathogen of great concern among fisheries and the aquaculture industry worldwide. Previous investigations have indicated the pathogenesis of BKD is complex. It is a chronic, multisystemic, granulomatous disease …
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The Immunomodulatory Functions Of Diacylglycerol Kinase Zeta On Type 2 Immune Responses
… are beneficial for orchestrating protective immune responses against helminths but can also be pathogenic in settings of allergy and asthma. Weak TCR-mediated extracellular signal-regulated kinase (ERK) signals are thought to promote Th2 differentiation in vitro. However, it was unclear …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
<p>Synovial tissue fibrosis is an immune mediated disease characterized by fibroblast cell migration, proliferation and transition to a myofibroblast phenotype characterized by alpha smooth muscle actin (a-SMA) upregulation and stress fiber formation. Transforming growth factor-β (TGF-b) plays an …
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Decoding division: single-cell insights into the transcriptional, proteomic and metabolic regulation of proliferating CD4+ T-cells
Understanding the immune system is central to developing effective treatments for immune-mediated diseases (IMDs). CD4+ T-cells, as key orchestrators of adaptive immunity, encompass a diverse range of subtypes that coordinate and regulate the immune response. Advances in immunogenomics have …
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Associations among physical activity, perception of stress, and relapse occurrence in multiple sclerosis
… multiple sclerosis (RRMS) is a chronic, immune-mediated disease that is characterized by relapses or periods of worsening symptoms (Lublin & Reingold, 1996). The occurrence of a relapse has been associated with experiencing a stressful event (Mohr, Hart, Julian, Cox, & Pelletier, 2004). …
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The acute effects of high-intensity interval and continuous aerobic exercise on physiological and functional outcomes in persons with multiple sclerosis
BACKGROUND: Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that results in physiological deconditioning and walking impairments. High-intensity interval training exercise (HIIT) has induced significant improvements in physiological conditioning in healthy and …
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… to help both humans and dogs diagnosed with diseases that carry dismal prognoses in both species: histiocytic sarcoma (HS), hemangiosarcoma (HSA), and disseminated mastocytosis (MCT). Lymphoma is one of the most common cancer types affecting dogs and humans, and therefore, novel therapeutic …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… are reported in patients not only with severe disease, but also in otherwise minimally symptomatic or asymptomatic people [1–3]. Notably, up to 65% of COVID-19 affected patients reported a wide range of neurological conditions, such as decreased sense of smell or hyposmia, dizziness, headache, …
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Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models
<p>Bone diseases and phenotypes are affected in multiple ways. We focused on studying the effects of genetic and environmental factors, especially their impact on bone properties. Firstly, we investigated the effects of β-caryophyllene (BCP), a naturally occurring dietary cannabinoid, on protecting …