Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Immune-Compromised"”.
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Equine Protozoal Myeloencephalitis: investigating immunopathogenesis and treatment efficacy in mouse models and clinically affected horses
… of exposed horses. The seemingly protective immune response that develops in some exposed horses but not all is not fully defined. Previous reports utilizing horse EPM models and immune compromised mouse models, which develop disease simulating EPM after infection with S. neurona, have …
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The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study
… secondary to opportunistic infections in the immune compromised host. Our study investigated the role of systemic markers of inflammation and oxidative stress, inflammatory changes in the brain on magnetic resonance spectroscopy (MRS) and the role of the APOE E4 allele in HIV-associated …
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Gliotoxin Production in Aspergillus fumigatus
… that causes an infection called aspergillosis in immune-compromised surgery patients (Latge, 2001, 384; Bok et al. 2006). Aspergillosis cases have increased in the past decade due to the increasing number of patients undergoing immunosuppressive therapy and receiving organ transplants (Bok et al. …
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Cache Valley Virus: A Comparison Across Both Lineages and Reassortant Strains Using in vitro and in vivo Models
… reassortant CVV strains. Pathogenesis studies in immune-compromised mice showed significant disease including weight loss, encephalitis, and mortality. To expand on our previous murine model studies and gain a better understanding of the pathogenicity of CVV isolates from both lineages as well as …
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Study of the Cryptosporidium parvum DHFR-TS in the model system Saccharomyces cerevisiae
… particularly for the very young, old, and immune-compromised. Currently there is no approved therapy for cryptosporidiosis. We have developed a method using the model organism Saccharomyces cerevisiae to rapidly screen for compounds effective against the C. parvum dihydrofolate reductase …
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
… fungal infections are a major threat to immune-compromised patients. There is a critical need to develop new antifungal agents because of increasing resistance to the common antifungal drugs.</p> <p>In the first part of this dissertation, methods for preparation of novel barbiturate …
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Cerebral Organoids as 3-Dimensional Grafts in Traumatic Brain Injury
… traumatic brain injuries to male NOD-SCID an immune-compromised mice line in the left motor cortex and acutely transplanted cortical organoids. For the examination of the neuronal subtype, we produced organoids enriched for glutamatergic, parvalbumin, and somatostatin neurons. We demonstrate …
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Identification of toxoplasma gondii genes involved in the strain-specific modulation of IL-12 cytokine secretion
… toxoplasmosis in developing fetuses and immune-compromised individuals. An immune response to a Toxoplasma infection is characterized by the stimulation of high levels of interleukin- 12 (IL- 12), followed by the production of interferon-y (IFN-y) by immune cells. Although IFN-y is the …
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Functional investigation of the role of the retinoblastoma protein in genome stability
… cells whose cell cycle regulation is already compromised by another mutation. This suggests that pRB’s functions in genome stability could underlie cancer relevant characteristics that are independent of its ability to negatively regulate proliferation. The overall aim of this thesis is to …
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Comparative structural analysis of cytochrome P450 family CYP51 in the genus Cryptococcus
… a life-threatening fungal infection in immune-compromised patients in poor countries. Studies indicate that mutations in CYP51 confer fluconazole resistance on cryptococcal species. Despite the importance of CYP51 in these species, genome data mining, annotation and phylogenetic analysis …
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Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
… significant cause of mortality and morbidity in immune-compromised individuals. Dectin-2, a C-type lectin receptor, is required for recognition of <em>C. albicans </em>by innate immune cells and is required for initiation of the anti-fungal immune response. We set out to identify components of …
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Interdependent Regulation of Cytomegalovirus Proteins in Complex
… significant morbidity and mortality in the immune compromised. Using the mutine cytomegalovirus (MCMV) model, we identified two genes, M140 and M141, which are determinants of macrophage tropism. Monocytes/macrophages are a critical cell type for cytomegalovirus (CMV) pathogenesis as sites …
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The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
… systemic, and vaginal infections, mostly in immune-compromised individuals. Azoles are the most common antifungals used in treating these infections. The most significant mechanisms of azole resistance include alterations or overexpression of the target enzyme, and overexpression of at least …
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AP2IX-4, a Cell Cycle Regulated Nuclear Factor, Modulates Gene Expression During Bradyzoite Development in Toxoplasma Gondii
… as the bradyzoite, which is impervious to the immune response. The tissue cysts facilitate wide-spread transmission through the food chain and give rise to chronic toxoplasmosis in immune compromised patients. In addition, they may reactivate into replicating tachyzoites which cause tissue …
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Sudden unexpected death in infants: a forensic genetic investigation in a South African cohort
… on two cases, which suggested one infant was immune-compromised and the second may have had bronchopulmonary dysplasia. The findings in this study highlight possible new candidate variants to assess in SUDI cases, and has directly contributed to the development of a molecular autopsy which is …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… chemotherapy. However, their clinical use is compromised by two major mechanisms of drug resistance: the overexpression of Pgp and bIII-tubulin. This dissertation describes the design and synthesis of pyrimido[4,5-b]indoles as tubulin inhibitors that circumvent Pgp and bIII-tubulin mediated …
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Profilo molecolare dei linfomi post-trapianto
… Burkitt lymphomas (BL). In order to evaluate the immune-profile a large panel of antibodies was applied including several new markers (Cyclin D2, Cyclin D3, p27, PKC-β, FOXP-1 and Survivin) identified as negative prognostic factors in DLBCL of the immunocompetent patient. Out of 50 DLBCL, 23 cases …
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Prevalence and factors associated with cryptosporidium infection among adult HIV positive population in contact with livestock in Namwala District, Zambia
… in the stool of an infected person or animal. In immune compromised individuals, Cryptosporidium infection can be serious, long-lasting and sometimes fatal. In Zambia, the burden of Cryptosporidium infection in the HIV positive population is unknown and factors associated with this infection are …
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Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice
… mimicked key aspects of viral pathogenesis and immune response. In this regard, new advances with humanized mice(hu-mice), constructed by engrafting human tissues and cells and harboring a functioning human immune system, have been of great value in advancing research with human viruses Here we …
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A Role for Mindbomb 1 in Adenovirus Genome Delivery
… cause severe respiratory illness in children and immune-compromised individuals. An initial genome-wide loss-of-function screen to identify host factors for this virus revealed MIB1, an E3 ubiquitin ligase best known for its role in neurodevelopment, as critical for AdV infectivity. In a series of …
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