Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 69 for “"Immune surveillance"”.
-
Investigating immune surveillance, tolerance, and therapy in cancer
… T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems largely relied on chemically-induced and spontaneous tumors in immunodeficient mice or on transplanted tumors. Such systems are limited because they fail to reproduce the complex interactions that …
-
Visualizing The Dynamics of Immune Surveillance In Brain Tumors By Intravital Multiphoton Microscopy
<p><strong>Visualizing the dynamics of immune surveillance in brain tumors by intravital multiphoton microscopy</strong></p> <p>By</p> <p>Felix I. Nwajei, MD</p> <p>Supervisory Professor: Tomasz Zal, Ph.D.</p> <p>Brain tumors (BTs) generally have a bad prognosis despite conventional treatment …
-
Estrogen Inducible Proteinase Inhibitor 9 Protects Target Cells From Immune Surveillance and Apoptosis
To test the effect of estrogen receptor (ER) ligands that induce PI-9 on TRAIL-mediated cytotoxicity, we used MCF-7, human breast cancer cells. In MCF-7 cells, induction of PI-9 by 17beta-estradiol (E2) inhibited TRAIL-mediated cytotoxicity. This is the first demonstration that regulation of PI-9 …
-
Simultaneous Induction of Nkg2D and Nkg2D Ligand For Promoting Immune Surveillance By Il-12 Plus Doxorubicin Treatment
… microenvironment directs tumor infiltrating immune cells to recognize tumor cells, stimulate cytotoxic effector immune cells, and therefore eradicate tumor cells. IL-12, a cytokine produced by antigen presenting cells, has remarkable antitumor effect by activating innate and adaptive …
-
Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
… lymphocytes has led to the hypothesis that our immune system actively inhibits the formation and progression of cancer, a phenomenon called tumor immune surveillance. T cells specific to mutant proteins have been identified in cancer patients and the recent success of cancer immunotherapies …
-
Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
<p>The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a …
-
The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. The functional maturation of NK cells is a tightly regulated process which is controlled by …
-
The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… a notable target, primarily activates the innate immune system, inducing strong antitumor responses. Direct cGAMP delivery into tumors has demonstrated significant antitumor effects in vivo. Despite this, knowledge gaps persist regarding immune cell types in the tumor microenvironment and their …
-
Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… from cancer patients and animal models that the immune system is able to recognise cancer cells. It is unclear whether tumours escape this immune surveillance by selection of non-immunogenic variants in a Darwinian process termed cancer immunoediting, or by the recruitment of immune suppressive …
-
Markers of immunosenescence and oxidative stress in healthy adults
… lymphocyte sub-populations important for immunosurveillance. This exercise also resulted in increased markers of oxidative stress in lymphocytes, and resulted in a whole body oxidative stress, which was more pronounced and prolonged, following ultra-endurance exercise. Studies also showed that …
-
Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
<p>Glycosylation of immune receptors and ligands, such as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of …
-
Chemical Biology Approaches to Interrogate Heat Shock Transcription Factor 1 Regulation in Cancer
… DNA damage repair, and evasion of host immune surveillance. Meanwhile, both our understanding of the molecular basis of HSF1 regulation as well as available biochemical tools to investigate such details are lacking. Based on an in vitro ligand binding approach, the studies presented in …
-
Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631
… site of tumor development and to play a role in immune surveillance against metastatic tumors. Investigating this mechanism, we studied B lymphocyte production of extracellular matrix-degrading proteinases: matrix metalloproteinases (MMPs) and components of the urokinase plasminogen activator (uP …
-
Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… disease. How cancer cells evade ensuing immune surveillance upon reactivation is poorly understood, but critical for the development of novel therapies to prevent metastatic relapse. Here, we identify focal adhesion kinase (Fak) as a critical regulator of metastatic reactivation and …
-
The role of NK cells in selectin-dependent tumor suppression
… of adhesion molecules that are critical for immune cell trafficking. In our laboratory, mice lacking all combinations of selectins have been generated. Previous work from our laboratory has demonstrated that, in the absence of selectins, human tumors transplanted subcutaneously into Rag2'- …
-
Systems Biology Analyses of Hematopoietic Cells
… new regulators of a signalling pathway in human immune cells. Cdc42 is a membrane associated GTPase that is an important regulator of cytoskeleton rearrangements and is required for natural killer (NK) cell activation. Previous work had shown that Cdc42 activity oscillates during NK immune …
-
Phosphorylation Regulation of T-Lymphocyte Migration
<p>Immune surveillance requires efficient trafficking of leukocytes throughout the body. To achieve this, leukocytes have evolved to be highly migratory and responsive to environmental cues, which provide guidance for proper tissue distribution. The translation of external environmental cues to …
Page 1 of 4