Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Immune stimulation"”.
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… play a fundamental role in driving muco-sal immune responses. These include, tolerance, associated with an M2-, regulatory macrophage phenotype and inflammatory activation with an M1-like phenotype. The cross-link between mucosal tolerance and inflammatory cytokine suppression, and …
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Improved Late-gestation Cardiac Morphology in Fetuses of Diabetic Mothers After Maternal Immune Stimulation: Potential Role of Dysregulated Apoptosis
… induced by hyperglycemia. Non-specific maternal immune stimulation is protective in mice against birth malformations caused by chemical or physical teratogens, or by maternal diabetes mellitus. Insulin dependent diabetes was induced in ICR females to study the late gestation fetal heart by …
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The role of IL-17a in the rescue of ASD-like behavioral phenotypes following immune stimulation in a mouse model of neurodevelopmental disorders
… temperature that is typically the product of the immune response mounted in order to fight infection. Investigation into the curious connection between fever and the manifestation of ASD behavioral phenotypes is at its infancy and therefore the mechanisms underlying this phenomenon are unknown. …
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Immunoteratological Studies of Diabetic Embryopathy Using Gene Expression Analysis
… of pregnant women with type I diabetes. Immune defects in the pathogenesis of diabetic embryopathy have been suggested. We hypothesized that activated immune system can counteract diabetic effect and result in prevention of diabetic embryopathy. Diabetes was induced in pregnant ICR mice …
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Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
… most common fetal malformations. Non-specific stimulation of maternal immune system prevents birth defects. This study investigated the role of dysregulated apoptosis in formation of NTDs from two teratogens: valproic acid (VA) and an unknown teratogen found in tap water. Interferon- γ (IFN γ) …
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
… 2006). We have found that non-specific maternal immune stimulation with the cytokine interferon-gamma (IFN-gamma) can successfully ameliorate some of these defects in the C57BL/6N mouse model. We have observed a reduction in the distal limb malformations syndactyly, polydactyly, and webbing by …
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ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
Immune stimulation fuels cell signaling-transcriptional programs that induce biological responses to eliminate virus-infected cells. Yet, retroviruses that integrate into host cell chromatin, such as HIV-1, co-opt these programs to switch between latent and reactivated states. However, many …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… cell (MSC) based immunotherapy to study the immune tumor microenvironment (TME), and optimized radiotherapy delivery with cGAMP and systemic α-PD-L1 immunotherapies. Using MSC, we delivered various forms of anti-CD3 and/or co-signals to explore their contribution to re-activate T cells inside …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… protected from reinfection. Since persistent immune stimulation can promote Tfh development, we treated mice at day 3 post infection with the antimalarial mefloquine (MQ) to reduce immune stimulation early in our system. This early MQ treatment resulted in a great expansion of IFN-γ+ Th1 cells …
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Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
… or t10,c12-CLA or a 50:50 mixture prior to immune stimulation with lipopolysaccharide and interferon-γ. Next, cultured mesangial cells were transfected with small interfering RNA (siRNA) targeting PPAR-γ and treated with CLA isomers prior to immune stimulation. ELISA, qPCR, Western blot, and …
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Hand-washing and its impact on child health in Kathmandu, Nepal
… in maldigestion or malabsorption of food and stimulation of the immune system, has been linked to growth faltering in young children in the developing world. Gut damage occurs along a spectrum, with only the more severe damage resulting in visible symptoms such as diarrhoea; most gut damage in …
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TLR3 Signaling in Human BDCA-3 Dendritic Cells Results in the Formation of Several ILT3 and ILT4 Populations
… cells (DCs) represent a population of innate immune cells that are highly efficient at promoting immune responses. DCs are capable of presenting antigens to both CD4 and CD8 T cells. DC presentation and interaction with T cells can result in either immune stimulation or tolerance. This study …
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Examining the Acute and Chronic Effects of Sepsis on the Circadian Clock in the Mouse
… relationships between the circadian and the immune systems, however while there is much evidence regarding the regulation of immune function by the circadian system, information regarding the impact of immune processes on the timekeeping system is more limited, including that regarding the …
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Study of the Evolutionary Role of Nitric Oxide (NO) in the Cephalochordate Amphioxus, “<i>Branchiostoma lanceolatum</i>”
… a different susceptibility to be induced after immune stimulation. The study of the promoter regions of these genes can be very useful to identify possible diversities in regulation that can lead those peculiar expression features. In amphioxus larva, NO was mainly detected in the developing …
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The Effects Of Microencapsulated Vitamin And Trace Mineral Premixes And Red Osier Dogwood Extract On Growth Performance, Immune Response, And Gut Health Of Broiler Chickens In A Coccidiosis Vaccine Challenge Model
… on growth performance, nutrient digestibility, immune response, and meat yield during a coccidiosis vaccine challenge using a 12x label dose of live coccidiosis vaccine in broiler chickens housed in bioassay cages. The first study evaluated the effects of red osier dogwood extract (RDE) …
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Understanding Inflammatory Bowel Disease using High-Throughput Sequencing
… changes in integrin gene expression following immune stimulation. These results reveal important insights into the genetic architecture of inflammatory bowel disease, and suggest that a combination of continued array-based genome- wide association studies, imputed using substantial new …
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Priming systemic anti-tumor immunity via in situ immunomodulation of the tumor microenvironment
… of cancer patients by driving tumor-directed immune responses. However, many patients do not benefit from such immunotherapies due to immune resistance mechanisms or severe inflammatory adverse events resulting in treatment discontinuation. Direct intratumoral injection of immunomodulatory …
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Age and Sex Related Behavioral Changes in Mice Congenitally Infected with Toxoplasma gondii: Role of dopamine and other neurotransmitters in the genesis of behavioral changes due to congenital infection and attempted amelioration with interferon gamma
… mouse model. Previous work demonstrated maternal immune stimulation (MIS) with interferon gamma (INF-g) resulted in decreased fetal mortality from congenital T. gondii infections; therefore I examined the effects of INF- g treatment of mothers to determine if protection from the behavioral effects …
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Neuroinflammation and Cognitive Impairment in the Aged: Implications for Nutritional Intervention
… anti-inflammatory effects in the peripheral immune system, including inhibition of inflammatory mediators by stimulated monocytes and macrophages. Although resveratrol has been shown to inhibit peripheral inflammation, its effects on the inflammatory response in the brain are unknown. If …
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Interleukin-6 trans-signaling: implications for neuroinflammation and cognitive deficits in the aged
… they were more sensitive to peripheral immune stimulation. Importantly, LPS-induced sickness behavior and cognitive deficits in aged animals were mitigated by icv sgp130. These behavioral effects were mirrored by a reduction of STAT3 phosphorylation, IL-6 mRNA expression, and protein …
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