Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 72 for “"Immune regulation"”.
-
Selective in vivo metabolic labeling for cell targeting and immune regulation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
-
CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
… a lysine demethylase involved in epigenetic regulation of gene expression. It catalyzes the demethylation of histone H3 lysine-27, counteracting the function of Polycomb Repressive Complex 2 (PRC2). Kdm6a plays a key role in transcriptional activation of genes that control cell …
-
The association of maternal HIV status during pregnancy on longitudinal neuro-immune regulation, and neurodevelopment in HIV-exposed uninfected children
… (HIV) and its effects, such as its impact on the immune system and then the numerous consequences on other biological systems including the central nervous system (CNS), have had a significant effect worldwide. This is particularly relevant in South Africa, where the prevalence of adults living …
-
The role of type I regulatory cells in regulating immune responses to influenza infection
… virus (IAV) infection requires T cell-dependent immune regulation. In severe cases, without appropriate control of the immune response, the inflammation resulting from respiratory viral infection can lead to pneumonia and death. It is known that regulatory T cells are important for many aspects …
-
Effects of dietary fermentable material on innate and adaptive immune measures in male and female rats under resting and immunized conditions
Sex-based differences in immune parameters are well recognized, and recent evidence suggests differences in microbiota composition between sexes, necessitating assessment of effects of dietary fermentable material (DFM) in both males and females. Effects of consumption of DFM of differing …
-
Role of Lymphocyte Populations Following Allogeneic Haematopoietic Stem Cell Transplantation // Роля на лимфоцитните популации след алогенна трансплантация на хемопоетични стволови клетки
… and delayed or incomplete recovery of the immune system. Following allo-HSCT, immune system reconstitution is a complex and prolonged process, which has critical importance for patient prognosis. Lymphocyte subpopulations play a key role in the immune regulation of recipients, and an …
-
ROLE OF MICRORNAS IN THE PATHOGENESIS OF ATOPIC DERMATITIS
… is characterized by skin barrier defect and immune dysregulation. In this study, we investigated the role of microRNA in AD pathogenesis. We found miR-335 to be highly expressed in the differentiating layers of normal epidermis but downregulated in AD. miR-335 overexpression in cultured basal …
-
Mechanisms of TRAF Signaling
… interactions are implicated in inflammation, immune regulation, bone homeostasis, and development. TNFR proteins lack intrinsic enzymatic activity, and are coupled to intracellular signaling cascades by TNFR associated factor (TRAF) proteins, which are cytoplasmic adaptor molecules. The roles …
-
Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
Resistance to immune checkpoint inhibitors (ICIs) remains a critical barrier to effective cancer therapy, driven by complex, multi-scale interactions that current biomarkers often fail to capture. This dissertation introduces the Biologically Disentangled Variational Autoencoder (BDVAE)—an …
-
INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… the viral reservoir, leading to persistent immune activation and inflammation despite combination antiretroviral therapy (cART). While cART has transformed HIV into a manageable chronic condition, it remains unable to eradicate the virus or fully restore immune homeostasis. This study …
-
Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… strategies to regulate their host’s immune response, to prevent expulsion and establish chronic infections. Understanding how they achieve this offers a therapeutic strategy for the treatment of human diseases which are caused by unregulated inflammation. Previous characterisation of …
-
The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
… addition of H. hepaticus resulting extreme up-regulation of TLR4 and the downstream effectors IRAK4 and NF-κB in Smad3⁻/⁻-infected colonic tissues. Examination of adaptive immune regulation in this model demonstrated that SMAD3 was necessary for FOXP3 expression in H. hepaticus-infected …
-
Functional characterization of human and chicken TLR3
… 3 (TLR3) is a critical component of the innate immune system, responsible for detecting viral double-stranded RNA (dsRNA) and initiating downstream signaling pathways, including activation of the transcription factor NF-κB. While TLR3 function has been extensively characterized in humans and …
-
Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the molecular …
-
EXPLORING THE MUTATIONAL LANDSCAPE OF MITOCHONDRIAL GENOME IN HEMATOLOGIC MALIGNANCIES
… mtDNA mutations in non-neoplastic immune effector cells, suggesting potential implications for immune surveillance. Together, these findings provide the first systematic characterization of mtDNA alterations across major hematologic malignancies. They highlight the widespread …
-
Contributions of Structural and Non-structural Genes to the Attenuation of the 17D Vaccine
… for viral replication and modulate the host immune response. The hypothesis to be tested in this dissertation is to determine whether or not structural and non-structural (NS) protein genes encode major genetic determinants of attenuation and contribute to decreased virulence of the 17D …
-
Assessing the temporal role of miR-200 loss in murine models of NSCLC
… by epithelial-mesenchymal transition (EMT) and immune evasion. The microRNA 200 family is a master regulator of EMT and is implicated in immune regulation. In this study we have developed a novel genetically engineered mouse model (GEMM) and derived primary cell lines from them to explore the …
-
A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease
The potent immune regulatory capacity of mesenchymal stromal cells (MSC) has been extensively characterised in terms of T cells, natural killer cells and dendritic cells suppression; however the ability of MSC to modulate B cell biology is not fully understood. This immune suppressive ability has …
-
Modulation of immune responses by human paraininfluenza virus
… infections, a comprehensive study investigating immune responses to this respiratory pathogen was undertaken. A human ex vivo model of viral infection was developed. Priming by HPIV3 was compared to immune responses induced by influenza A virus, which unlike HPIV3 primes immunity to …
-
Mimicking the micro-environment. Construction and evaluation of complex collagen-based scaffolds for tissue engineering
Contains fulltext : 99159.pdf (Publisher’s version ) (Open Access)
Page 1 of 4