Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Immune privilege"”.
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Placental angiogenesis and immune-privilege in normal and pathological pregnancies
… in IUGR. Additional studies pertaining to immune-privilege of trophoblasts and choriocarcinoma have also been provided which indicated co-expression of Fas and FasL in malignant trophoblasts. The data suggest that choriocarcinoma cells could evade immune attack by down regulation of Fas …
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Role of IL-17A and Acaid in the Maintenance of Corneal Immune Privilege
… trauma to the corneal endothelium. This local immune deviation is achieved through multiple anatomical, physiological, and immunoregulatory features intrinsic to the ocular environment that allow the cornea to enjoy an immune privileged status. Corneal immune privilege allows first time …
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EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege
… homology with F4/80 and EMR2 has shown immune suppressing function in tumor cells. Thus, we investigate the possible suppressor role of the EMR family in human ocular tolerance. METHODS: Human peripheral blood mononuclear cells (huPBMC) were treated with porcine TGFβ2 and LPS or an …
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The role of miRNA-486-5p in hair growth and the hair follicle immune privilege
… one of the key factors contributing to the immune privilege (IP) collapse in HFs. Intradermal delivery of miR-486-5p mimic into mouse skin affected by AA prevented premature entrance of HFs into catagen phase and reduced the numbers of CD4+ and CD8+ lymphocytes in the peri- and …
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Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… the eye from inflammatory damage, referred to as immune privilege. The mechanisms that protect the eye from inflammation-induced injury are 1.) the presence of immunosuppressive molecules within the aqueous humor; 2.) the expression of pro-apoptotic factors on corneal cells ; and 3.) the induction …
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Role of Allergic Conjunctivitis in Inducing Corneal Transplant Rejection
… eye that decrease the likelihood of mounting an immune response, a phenomenon called "immune privilege". Despite this characteristic, immune rejection remains the leading cause of corneal graft failure, indicating that immune privilege can be abolished. We used a model of corneal transplantation …
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Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
… pathogen. These mechanisms activate the innate immune response during inflammation, however, in the ‘normal’ eye, immunomodulatory components exist to promote immune privilege. 11beta hydroxysteroid dehydrogenase 1 (11β-HSD1) regulates cortisol locally in tissues and has already been localised …
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Immune-Mediated Mechanisms of Phthisical and Non-Phthisical Intraocular Tumor Rejection
Although intraocular tumors reside in an immunoprivileged site where immune responses are suppressed, some tumors are rejected nonetheless. An example of this is the syngeneic adenovirus-induced (Ad5E1) tumor model. Intraocular tumors are rejected in one of two pathways: one that maintains normal …
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Precision Cytokine Therapy: Engineering and Delivery of CD8- and CAR-Tropic Interleukin-2 Variants
… one potential strategy, although the unique immune-privileged status of the brain poses a major challenge to its success. Immune privilege refers to the limited ability of the central nervous system (CNS) to generate strong immune responses against foreign antigens. This results from the …
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The Multifunctional Melanocortin System in the Human Choroid
… includes extracellular matrix, blood vessels, immune cells, nerves, fibroblasts, and melanocytes. As one of the most abundant cells within the choroid, melanocytes contribute significantly to the normal intraocular environment, including light absorption, antioxidant activity, free-radical …